Results 131 to 140 of about 6,340 (159)

Purification and Characterization of a Functional Soluble Fibroblast Growth Factor Receptor 1

Biochemical and Biophysical Research Communications, 1994
Naturally encoded human soluble fibroblast growth factor receptor 1 was cloned, abundantly expressed by recombinant baculovirus-infected insect cells and purified to apparent homogeneity. Pure soluble receptor bound as monomeric and dimeric complexes and inhibited the mitogenic activity of basic and acidic fibroblast growth factors.
G, Wang, K A, Thomas
openaire   +2 more sources

Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells

Blood, 2002
Recent experiments show that hematopoietic progenitor cell populations contain endothelial precursor cells. We have isolated a population of CD34(+) cells that expresses fibroblast growth factor receptor-1 (FGFR-1) and that differentiates into endothelial cells in vitro. We find that 4.5% +/- 2.1% of CD34(+) cells isolated from bone marrow, cord blood,
Patricia E, Burger, Sandra, Coetzee, Wallace L, McKeehan, Mikio, Kan, Perry, Cook, Yong, Fan, Toshio, Suda, Robert P, Hebbel, Nicolas, Novitzky, William A, Muller, E Lynette, Wilson   +10 more
openaire   +2 more sources

Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1

Cellular Signalling, 2004
Binding of fibroblast growth factor (FGF) to the high affinity receptor-1 (FGFR-1) leads to activation of its endogenous tyrosine kinase activity. A number of substrates for the FGFR-1 kinase have been identified. Among those, FGF receptor-substrate-2 (FRS-2) was identified by virtue of its interaction with p13suc, a yeast protein involved in cell ...
Peter, Klint, Ulf, Hellman, Christer, Wernstedt, Pierre, Aman, David, Ron, Lena, Claesson-Welsh   +5 more
openaire   +2 more sources

Epithelial Fibroblast Growth Factor Receptor 1 Regulates Enamel Formation

Journal of Dental Research, 2008
The interaction between epithelial and mesenchymal tissues plays a critical role in the development of organs such as teeth, lungs, and hair. During tooth development, fibroblast growth factor (FGF) signaling is critical for regulating reciprocal epithelial and mesenchymal interactions.
K, Takamori, R, Hosokawa, X, Xu, X, Deng, P, Bringas, Y, Chai   +5 more
openaire   +2 more sources

Fibroblast growth factor receptor‐1 interacts with the T‐cell receptor signalling pathway

Immunology & Cell Biology, 2003
Fibroblast growth factor receptors are expressed by some T cells, and provide costimulation for these cells. Such receptors allow T cells to respond to fibroblast growth factors expressed in response to injury and inflammation and may provide a mechanism for ‘context‐dependent’ responses to antigens within the local microenvironment.
Victor M, Byrd, Dawn M, Kilkenny, Michael M, Dikov, Martha B, Reich, Jonathan V, Rocheleau, Wade J, Armistead, James W, Thomas, Geraldine G, Miller   +7 more
openaire   +2 more sources

Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain

Journal of Comparative Neurology, 2003
AbstractFactors that interact with the epidermal growth factor and fibroblast growth factor receptors have numerous effects in the central nervous system (CNS), inducing the proliferation of CNS stem cells and astrocytes and the survival and differentiation of neurons.
Lijuan, Fu, Amir, Abu-Khalil, Richard S, Morrison, Daniel H, Geschwind, Harley I, Kornblum   +4 more
openaire   +2 more sources

Fibroblast growth factor-10 and fibroblast growth factor receptors 1–4: expression and peptide localization in human decidua and placenta

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2005
The development of the chorionic villous tree into a complex and organized ramified tubular network can be termed branching morphogenesis. Studying the molecular mechanisms involved in this process may contribute to the understanding of pregnancy complications such as preeclampsia.
Eyal Y, Anteby, Shira, Natanson-Yaron, Yaron, Hamani, Yael, Sciaki, Debra, Goldman-Wohl, Caryn, Greenfield, Ilana, Ariel, Simcha, Yagel   +7 more
openaire   +2 more sources

Prostate cells express two isoforms of fibroblast growth factor receptor 1 with different affinities for fibroblast growth factor‐2

The Prostate, 2006
AbstractBackgroundFibroblast growth factor receptor 1 (FGFR1) mRNA can be alternatively spliced to generate isoforms containing (FGFR1α) or lacking (FGFR1β) the first immunoglobulin‐like domain. We examined which isoforms are expressed by cultured prostate cells, their affinities for FGF‐2, and the effect of heparin on FGF‐2 binding.MethodsFGFR1 ...
Monireh, Roghani, David, Moscatelli
openaire   +2 more sources

Single-domain antibodies that compete with the natural ligand fibroblast growth factor block the internalization of the fibroblast growth factor receptor 1

Biochemical and Biophysical Research Communications, 2011
Single-domain antibodies in VHH format specific for fibroblast growth factor receptor 1 (FGFR1) were isolated from a phage-display llama naïve library. In particular, phage elution in the presence of the natural receptor ligand fibroblast growth factor (FGF) allowed for the identification of recombinant antibodies that compete with FGF for the same ...
Gianluca, Veggiani, Giuseppe, Ossolengo, Marisa, Aliprandi, Ugo, Cavallaro, Ario, de Marco   +4 more
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Özge Gümüsay, Damé Idossa   +2 more
exaly