Results 211 to 220 of about 221,633 (255)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Prevent or Treat? Evaluating a Delayed Treatment With Nintedanib After Murine Orthotopic Tracheal Transplantation. [PDF]

Transplant Direct
Mauer J, Graebner C, Kuckhahn A, Ramsperger-Gleixner M, Weyand M, Heim C.   +5 more
europepmc   +1 more source

FGFR2 and favorable survival outcomes in resected poorly cohesive cell gastric cancer: Analysis from FGFR2 protein overexpression and genetic variation. [PDF]

PLoS One
Lee YJ, Jung I, Baek JH, Kim JG, Park KB, Park JY, Kwon OK, Seo AN, Kim M, Kang BW.   +9 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibroblast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Candice, Wakulich, Linda, Jackson-Boeters, Tom D, Daley, George P, Wysocki   +3 more
openaire   +2 more sources

Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2

Angewandte Chemie International Edition, 2021
AbstractAberrant activation of FGFR signaling occurs in many cancers, and ATP‐competitive FGFR inhibitors have received regulatory approval. Despite demonstrating clinical efficacy, these inhibitors exhibit dose‐limiting toxicity, potentially due to a lack of selectivity amongst the FGFR family and are poorly tolerated.
Guangyan Du, Jie Jiang, Qibiao Wu, Nathaniel J. Henning, Katherine A. Donovan, Hong Yue, Jianwei Che, Wenchao Lu, Eric S. Fischer, Nabeel Bardeesy, Tinghu Zhang, Nathanael S. Gray   +11 more
openaire   +2 more sources

Immunclocalization of Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1 and Receptor-2 in Rat Cranial Sutures

Plastic and Reconstructive Surgery, 1998
Craniosynostosis is a common disorder with an unknown etiology. Recent genetic mapping studies have demonstrated a strong linkage between several familial craniosynostotic syndromes and mutations in fibroblast growth factor receptor 1 (FGF-R1) and 2 (FGF-R2).
B J, Mehrara, R J, Mackool, J G, McCarthy, G K, Gittes, M T, Longaker   +4 more
openaire   +2 more sources

Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma

Human Pathology, 2014
Patients with cholangiocarcinoma often present with locally advanced or metastatic disease. There is a need for effective therapeutic strategies for advanced stage cholangiocarcinoma. Recently, FGFR2 translocations have been identified as a potential target for tyrosine kinase inhibitor therapies.
Rondell P, Graham, Emily G, Barr Fritcher, Ekaterina, Pestova, John, Schulz, Leonid A, Sitailo, George, Vasmatzis, Stephen J, Murphy, Robert R, McWilliams, Steven N, Hart, Kevin C, Halling, Lewis R, Roberts, Gregory J, Gores, Fergus J, Couch, Lizhi, Zhang, Mitesh J, Borad, Benjamin R, Kipp   +15 more
openaire   +2 more sources

Uterine fibroblast growth factor-2 and embryonic fibroblast growth factor receptor-1 at the beginning of gastrulation in the rabbit

Anatomy and Embryology, 1996
Fibroblast growth factor-2 (FGF-2) induces gastrulation of rabbit blastocysts in vitro and is present in the uterine secretion at day 6 after mating. The following study was made in order to show if changes in the uterine FGF-2 concentration or in the FGF receptor concentration of the embryonic tissues point to a regulation of this event. By the use of
C, Gründker, C, Kirchner
openaire   +2 more sources

Fibroblast growth factor receptor 2 expression in apical periodontitis in mice

International Endodontic Journal, 2020
AbstractAimTo investigate the presence, localization and the possible correlation of the fibroblast growth factor receptor‐2 (FGFR2) with inflammatory resorption of cementum, periodontal ligament and alveolar bone during development of apical periodontitis in mice.MethodologyApical periodontitis was experimentally induced in mandibular first molars of ...
A. De Rossi, S. D. Huamán, J. E. León, M. C. P. Saraiva, S. Y. Fukada, R. A. B. da Silva, F. de Carvalho, P. Nelson‐Filho   +7 more
openaire   +2 more sources