Results 221 to 230 of about 221,633 (255)
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Cell Biology International, 2005
Although fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor 3 (FGFR3) both inhibit longitudinal bone growth, little is known about the relationship between FGF2 and FGFR3. Accordingly, the current study examined the expression of FGFR3 mRNA after the administration of FGF2 using cultured chondrocytes from day 17 chick embryos to ...
Jo-Young, Suh +4 more
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Although fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor 3 (FGFR3) both inhibit longitudinal bone growth, little is known about the relationship between FGF2 and FGFR3. Accordingly, the current study examined the expression of FGFR3 mRNA after the administration of FGF2 using cultured chondrocytes from day 17 chick embryos to ...
Jo-Young, Suh +4 more
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Molecular Membrane Biology, 1997
Double electrode voltage clamp technique was used to follow precisely the calcium signalling pathway activated by FGF receptors from a normal and a carcinogenous cell environment. Functional FGF receptors were expressed in Xenopus oocytes following either the injection of PFR1 cRNA from Pleurodeles, an homologue of the human FGFR1 mRNA, or breast ...
Malo, Michel +4 more
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Double electrode voltage clamp technique was used to follow precisely the calcium signalling pathway activated by FGF receptors from a normal and a carcinogenous cell environment. Functional FGF receptors were expressed in Xenopus oocytes following either the injection of PFR1 cRNA from Pleurodeles, an homologue of the human FGFR1 mRNA, or breast ...
Malo, Michel +4 more
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Fibroblast growth factor receptor 2 (FGFR2): genomic sequence and variations
Cytogenetic and Genome Research, 2001Fibroblast growth factor receptors (FGFRs) play an important role in development and tumorigenesis. Mutations in FGFR2 cause more than five craniosynostosis syndromes. The FGFR2 genomic structure is the largest of the FGFR family. We have refined and extended the genomic organization of the FGFR2 gene by sequencing more than 119 kb of PACs, cosmids ...
R G, Ingersoll +5 more
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Fibroblast growth factor receptor 2: a therapeutic target in gastric cancer
Expert Review of Gastroenterology & Hepatology, 2013Gastric cancer remains a leading cause of cancer-related death in the world. FGF receptor 2 (FGFR2) is preferentially amplified and overexpressed in the diffuse type of gastric cancer. This review evaluates the expression and function of FGFR2 in gastric cancer, and analyzes the use of its inhibitors for gastric cancer therapy.
Liu, Hong +3 more
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Overexpression of the fibroblast growth factor receptor 2-IIIc in Kaposi's sarcoma
Journal of Dermatological Science, 2009Kaposi's sarcoma (KS) is a neoplastic disorder characterized by a highly vascularized lesion with bundles of spindle-shaped cells, pathognomonic of the disease, infiltrated by mononuclear inflammatory and plasma cells. The KS lesion presents as a patch/plaque, which eventually develops into a nodular tumor.
Francesca Cottoni +9 more
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Endocrinology, 1994
In situ hybridization and immunohistochemistry were used to map gene expression and protein distribution of basic fibroblast growth factor (FGF-2) in the hypothalamic-pituitary system. Although the expression of FGF-2 mRNA in the pituitary is low, the protein is widely distributed in both its neural and anterior lobes.
A M, Gonzalez +5 more
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In situ hybridization and immunohistochemistry were used to map gene expression and protein distribution of basic fibroblast growth factor (FGF-2) in the hypothalamic-pituitary system. Although the expression of FGF-2 mRNA in the pituitary is low, the protein is widely distributed in both its neural and anterior lobes.
A M, Gonzalez +5 more
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The Prostate, 2006
AbstractBackgroundFibroblast growth factor receptor 1 (FGFR1) mRNA can be alternatively spliced to generate isoforms containing (FGFR1α) or lacking (FGFR1β) the first immunoglobulin‐like domain. We examined which isoforms are expressed by cultured prostate cells, their affinities for FGF‐2, and the effect of heparin on FGF‐2 binding.MethodsFGFR1 ...
Monireh, Roghani, David, Moscatelli
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AbstractBackgroundFibroblast growth factor receptor 1 (FGFR1) mRNA can be alternatively spliced to generate isoforms containing (FGFR1α) or lacking (FGFR1β) the first immunoglobulin‐like domain. We examined which isoforms are expressed by cultured prostate cells, their affinities for FGF‐2, and the effect of heparin on FGF‐2 binding.MethodsFGFR1 ...
Monireh, Roghani, David, Moscatelli
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The FASEB Journal, 2002
ABSTRACT Vascular endothelial growth factor (VEGF) activates endothelial cells, in part, by interacting with the kinase insert domain‐containing receptor (KDR) receptor tyrosine kinase. Although progress has been made in the identification of cell‐signaling proteins that participate in the VEGF‐induced response, questions remain ...
Konstantin V, Stoletov +2 more
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ABSTRACT Vascular endothelial growth factor (VEGF) activates endothelial cells, in part, by interacting with the kinase insert domain‐containing receptor (KDR) receptor tyrosine kinase. Although progress has been made in the identification of cell‐signaling proteins that participate in the VEGF‐induced response, questions remain ...
Konstantin V, Stoletov +2 more
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Fibroblast Growth Factor Receptor‐2 Mutations in Craniosynostosisa
Annals of the New York Academy of Sciences, 1996S, Malcolm, W, Reardon
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Cancer research, 2001
Autosomal dominant disorders of skeletal and cranial development have been linked to fibroblast growth factor receptor (FGFR) 2 and FGFR3. Here we report two identical mutations in FGFR2 that cause craniosynostosis syndromes, Crouzon, Apert, and Pfeiffer in gastric carcinoma.
J H, Jang, K H, Shin, J G, Park
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Autosomal dominant disorders of skeletal and cranial development have been linked to fibroblast growth factor receptor (FGFR) 2 and FGFR3. Here we report two identical mutations in FGFR2 that cause craniosynostosis syndromes, Crouzon, Apert, and Pfeiffer in gastric carcinoma.
J H, Jang, K H, Shin, J G, Park
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