Results 51 to 60 of about 527,589 (284)
Kidney Diseases, 2020 Background: Our recent studies demonstrated that both nintedanib, an FDA-approved quadruple kinase inhibitor, and gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, protect against obstructive kidney disease. It remains unknown whether they
Liu Feng +9 more
doaj +1 more source
The role of growth factors in human sperm parameters: A review of in vitro studies
International Journal of Reproductive BioMedicine, 2022 In vitro sperm preparation/incubation and cryopreservation are associated with oxidative stress as the main cause of sperm damage, and different strategies are used to improve sperm quality in in vitro conditions to treat male infertility. Growth factors
Hanieh Ghasemian Nafchi +2 more
doaj +1 more source
Cancer Research, 2010 Members of the fibroblast growth factor receptor (FGFR) family have essential roles in normal physiology and in cancer where they control diverse processes. FGFRs have been associated with breast cancer development. Thus, models to study the role of FGFR
J. Dey +5 more
semanticscholar +1 more source
Molecular characteristics of fibroblast growth factor–fibroblast growth factor receptor–heparin-like glycosaminoglycan complex [PDF]
Proceedings of the National Academy of Sciences, 1999 Fibroblast growth factor (FGF) family plays key roles in development, wound healing, and angiogenesis. Understanding of the molecular nature of interactions of FGFs with their receptors (FGFRs) has been seriously limited by the absence of structural information on FGFR or FGF–FGFR complex.
G, Venkataraman +3 more
openaire +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Role of FGF System in Neuroendocrine Neoplasms: Potential Therapeutic Applications
Frontiers in Endocrinology, 2021 Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors originating from neuroendocrine cells dispersed in different organs. Receptor tyrosine kinases are a subclass of tyrosine kinases with a relevant role in several cellular processes ...
Giovanni Vitale +9 more
doaj +1 more source
FGFR4 (fibroblast growth factor receptor 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Peer ...
Peláez-García, A +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
BRET biosensor analysis of receptor tyrosine kinase functionality
Frontiers in Endocrinology, 2013 Bioluminescence resonance energy transfer (BRET) is an improved version of earlier resonance energy transfer technologies used for the analysis of biomolecular protein interaction.
Sana eSiddiqui +4 more
doaj +1 more source
Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors
Communications Chemistry, 2022 The human fibroblast growth factor receptors (FGFRs) are attractive targets for cancer therapy, but the structural basis for kinase targeting and gatekeeper mutations of covalent FGFR inhibitors are not fully understood.
Lingzhi Qu +9 more
doaj +1 more source