Results 31 to 40 of about 527,589 (284)

Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A). [PDF]

PLoS Pathogens, 2013
Botulinum neurotoxin serotype A (BoNT/A) causes transient muscle paralysis by entering motor nerve terminals (MNTs) where it cleaves the SNARE protein Synaptosomal-associated protein 25 (SNAP25206) to yield SNAP25197.
Birgitte P S Jacky, Patton E Garay, Jérôme Dupuy, Jeremy B Nelson, Brian Cai, Yanira Molina, Joanne Wang, Lance E Steward, Ron S Broide, Joseph Francis, K Roger Aoki, Raymond C Stevens, Ester Fernández-Salas   +12 more
doaj   +1 more source

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations.

Cytokine & growth factor reviews, 2015
The four receptor tyrosine kinases (RTKs) within the family of Fibroblast Growth Factor Receptors (FGFRs) are critical for normal development but also play an enormous role in oncogenesis.
Leandro H. Gallo, Katelyn N. Nelson, A. N. Meyer, D. Donoghue   +3 more
semanticscholar   +1 more source

Developmental process and expression patterns of fibroblast growth factor receptors in murine meniscus after birth

Di-san junyi daxue xuebao, 2019
Objective To observe the developmental process of murine meniscus after birth and investigate the expression patterns of 3 types of fibroblast growth factor receptors (FGFRs) during this process. Methods Mice at different ages (1 d old and 1, 2, 4, 6 and
LI Fangfang, XIE Yangl, HUANG Junlan, ZHANG Ruobin, JIANG Wanling   +4 more
doaj   +1 more source

The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study

EBioMedicine, 2015
Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. We here describe insights underpinning the impact of mutations on FGFR1 and FGFR3 kinase activity and drug efficacy, using a combination of computational ...
T. D. Bunney, S. Wan, N. Thiyagarajan, L. Sutto, Sarah V. Williams, P. Ashford, H. Koss, M. Knowles, F. Gervasio, P. Coveney, M. Katan   +10 more
semanticscholar   +1 more source

Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation

iScience, 2019
Summary: Lung epithelial cells and fibroblasts are key cell populations in lung development. Fibroblasts support type 2 alveolar epithelial cells (AEC2) in the developing and mature lung.
Kazushige Shiraishi, Shigeyuki Shichino, Satoshi Ueha, Takuya Nakajima, Shinichi Hashimoto, Satoshi Yamazaki, Kouji Matsushima   +6 more
doaj   +1 more source

FGFR (fibroblast growth factor receptor) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008
Review on FGFR3 (fibroblast growth factor receptor 3), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +3 more sources

Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling

Cell Communication and Signaling, 2021
Interleukin-17 receptor D (IL17RD or IL-17RD) also known as Sef (similar expression to fibroblast growth factor), is a single pass transmembrane protein that is reported to regulate several signaling pathways .
Shivangi Pande, Xuehui Yang, Robert Friesel   +2 more
doaj   +1 more source

Basic fibroblast growth factor and its receptors in human embryonic stem cells.

Folia Histochemica et Cytobiologica, 2005
Human embryonic stem cells (hESCs) are pluripotent stem cells with long-lasting capacity to self-renew and differentiate into various cell types of endodermal, ectodermal or mesodermal origin.
Ales Hampl, Petr Dvorak
doaj   +1 more source

Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants

Communications Chemistry, 2022
Pemigatinib is an FDA-approved drug for the treatment of cholangiocarcinoma, but while it is known to target fibroblast growth factor receptors, its mechanism of action is still not fully understood.
Qianmeng Lin, Xiaojuan Chen, Lingzhi Qu, Ming Guo, Hudie Wei, Shuyan Dai, Longying Jiang, Yongheng Chen   +7 more
doaj   +1 more source

Morphofunctional Characterization of Different Tissue Factors in Congenital Diaphragmatic Hernia Affected Tissue

Diagnostics, 2021
Congenital diaphragm hernia (CDH) is a congenital disease that occurs during prenatal development. Although the morbidity and mortality rate is rather significant, the pathogenesis of CDH has been studied insignificantly due to the decreased ...
Ricards Kaulins, Laura Ramona Rozite, Mara Pilmane, Aigars Petersons   +3 more
doaj   +1 more source