Results 11 to 20 of about 527,589 (284)
Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers. [PDF]
Apoptosis, 2013 The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair.
Tiong KH, Mah LY, Leong CO.
europepmc +4 more sources
Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins [PDF]
Cells, 2019 Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute signaling circuits that transmit signals across the plasma membrane, regulating pivotal cellular processes like differentiation, migration, proliferation, and apoptosis.
Marta Latko +6 more
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Signal transduction by fibroblast growth factor receptors. [PDF]
Frontiers in Bioscience, 1999 The fibroblast growth factor family, with its prototype members acidic FGF (FGF-1) and basic FGF (FGF-2), binds to four related receptor tyrosine kinases, expressed on most types of cells in tissue culture. In many respects, the FGF receptors appear similar to other growth factor receptors. Thus, dimerization of receptor monomers upon ligand binding is
P. Klint, L. Claesson-Welsh
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Targeting mutant fibroblast growth factor receptors in cancer. [PDF]
Trends Mol Med, 2011 Fibroblast growth factor receptors (FGFRs) play diverse roles in the control of cell proliferation, cell differentiation, angiogenesis and development. Activating the mutations of FGFRs in the germline has long been known to cause a variety of skeletal ...
Greulich H, Pollock PM.
europepmc +2 more sources
F1000ResearchFibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler +2 more
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Fibroblast Growth Factor Receptors (FGFRs) in Human Sperm: Expression, Functionality and Involvement in Motility Regulation. [PDF]
PLoS ONE, 2015 Fibroblast growth factors receptors (FGFRs) have been widely characterized in somatic cells, but there is scarce evidence of their expression and function in mammalian gametes. The objective of the present study was to evaluate the expression of FGFRs in
Lucía Saucedo +7 more
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Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis [PDF]
Cytokine & Growth Factor Reviews, 2005 Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins.
PRESTA, Marco +5 more
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VEGFR1-tyrosine kinase signaling in pulmonary fibrosis
Inflammation and Regeneration, 2021 Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano +4 more
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Frontiers in Oncology, 2023 Nintedanib is a tyrosine kinase inhibitor of fibroblast growth factor-, vascular endothelial growth factor-, and platelet-derived growth factor receptors.
Shu Yan +6 more
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