Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors [PDF]
Cells, 2019 Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells.
Shuyan Dai +4 more
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Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling [PDF]
Cells, 2021 Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson +2 more
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Fibroblast growth factor receptors in breast cancer [PDF]
Tumor Biology, 2017 Fibroblast growth factor receptors are growth factor receptor tyrosine kinases, exerting their roles in embryogenesis, tissue homeostasis, and development of breast cancer.
Shuwei Wang, Zhongyang Ding
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Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer [PDF]
Gastroenterology Research and Practice, 2015 Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer (GC), although outcomes remain unfavorable.
Mikito Inokuchi +5 more
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Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors. [PDF]
PLoS ONE, 2013 Malignant rhabdoid tumors (MRTs) are aggressive pediatric cancers arising in brain, kidney and soft tissues, which are characterized by loss of the tumor suppressor SNF5/SMARCB1.
Simon Wöhrle +17 more
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Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance. [PDF]
Br J Cancer, 2021 Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human cancers, although this frequency increases to 10–30% in urothelial carcinoma and ...
Krook MA +7 more
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The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments. [PDF]
Int J Mol Sci, 2020 Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer as cause of deaths in women. Notwithstanding many progresses made in the field, metastatic BC has a very poor prognosis. As therapies are becoming more personalized
Navid S +5 more
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Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae [PDF]
PeerJ, 2022 Background and Objective A key pathway controlling skeletal development is fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling. Major regulatory functions of FGF signaling are chondrogenesis, endochondral and intramembranous bone development.
Liesbeth Gebuijs +5 more
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Fibroblast growth factor receptors as targets for anticancer therapy in cholangiocarcinomas and urothelial carcinomas [PDF]
Heliyon, 2023 Cholangiocarcinomas and urothelial carcinomas are lethal tumors worldwide and only a minority of patients are eligible for surgery at diagnosis.
Demi Wekking +7 more
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Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment. [PDF]
J Clin Med, 2018 Fibroblast growth factor receptors (FGFRs) in response to fibroblast growth factors (FGFs) transmit signals across the cell membrane, regulating important cellular processes, like differentiation, division, motility, and death.
Porębska N +5 more
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