Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors [PDF]
Cells, 2019 Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells.
Shuyan Dai +4 more
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Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins [PDF]
Cells, 2019 Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute signaling circuits that transmit signals across the plasma membrane, regulating pivotal cellular processes like differentiation, migration, proliferation, and apoptosis.
Marta Latko +6 more
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Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling [PDF]
Cells, 2021 Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson +2 more
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Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae [PDF]
PeerJ, 2022 Background and Objective A key pathway controlling skeletal development is fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling. Major regulatory functions of FGF signaling are chondrogenesis, endochondral and intramembranous bone development.
Liesbeth Gebuijs +5 more
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Fibroblast growth factor receptors as targets for anticancer therapy in cholangiocarcinomas and urothelial carcinomas [PDF]
Heliyon, 2023 Cholangiocarcinomas and urothelial carcinomas are lethal tumors worldwide and only a minority of patients are eligible for surgery at diagnosis.
Demi Wekking +7 more
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Fibroblast growth factor receptors in breast cancer [PDF]
Tumor Biology, 2017 Fibroblast growth factor receptors are growth factor receptor tyrosine kinases, exerting their roles in embryogenesis, tissue homeostasis, and development of breast cancer.
Shuwei Wang, Zhongyang Ding
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Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer [PDF]
Gastroenterology Research and Practice, 2015 Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer (GC), although outcomes remain unfavorable.
Mikito Inokuchi +5 more
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Role of Klotho in Hyperglycemia: Its Levels and Effects on Fibroblast Growth Factor Receptors, Glycolysis, and Glomerular Filtration. [PDF]
Int J Mol Sci, 2021 Typiak M +7 more
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The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments. [PDF]
Int J Mol Sci, 2020 Navid S +5 more
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Expression and localization of fibroblast growth factors and fibroblast growth factor receptors in the developing rat kidney [PDF]
Kidney International, 1999 Expression and localization of fibroblast growth factors and fibroblast growth factor receptors in the developing rat kidney.The permanent kidney, or metanephros, develops through a complex series of reciprocal inductive events and involves branching morphogenesis, tubulogenesis, angiogenesis, and tissue remodeling. Fibroblast growth factors (FGFs) are
John Frederick Bertram
exaly +3 more sources