Results 271 to 280 of about 1,904,768 (328)
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Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs
Recent Patents on Cardiovascular Drug Discovery, 2006Maintenance of endothelial cells (ECs), the building blocks of the vascular tree, is a presumed function of fibroblast growth factors (FGFs). In particular, the two prototypic members of FGF family, namely FGF1 and FGF2, due to their potent mitogenic and pro-migratory activities, have the ability to induce metabolic and phenotypic changes in ECs that ...
Gregory J, Chen, Reza, Forough
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Fibroblast Growth Factor Prototype Release and Fibroblast Growth Factor Receptor Signaling
Thrombosis and Haemostasis, 1999A Brief Introduction to the Fibroblast Growth Factor Gene Family The fibroblast growth factor (FGF) family of genes presently comprise 18 members, including the two prototypes, FGF-1 (acidic) and FGF-2 (basic). Although the FGF prototypes are well described as mediators of a variety of diverse biological responses, such as mesoderm induction ...
R, Friesel, T, Maciag
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2003
We have reviewed data showing that FGFs are a family of related factors playing fundamental roles in several biologic processes involving tissue remodeling such as embryonic development, angiogenesis, wound healing, nerve regeneration, and chronic inflammation and cancer.
Ensoli, B +3 more
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We have reviewed data showing that FGFs are a family of related factors playing fundamental roles in several biologic processes involving tissue remodeling such as embryonic development, angiogenesis, wound healing, nerve regeneration, and chronic inflammation and cancer.
Ensoli, B +3 more
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Differentiation
Fibroblast growth factor 10 (FGF10) is a major morphoregulatory factor that plays essential signaling roles during vertebrate multiorgan development and homeostasis. FGF10 is predominantly expressed in mesenchymal cells and signals though FGFR2b in adjacent epithelia to regulate branching morphogenesis, stem cell fate, tissue differentiation and ...
Francesca Rochais, Robert G. Kelly
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Fibroblast growth factor 10 (FGF10) is a major morphoregulatory factor that plays essential signaling roles during vertebrate multiorgan development and homeostasis. FGF10 is predominantly expressed in mesenchymal cells and signals though FGFR2b in adjacent epithelia to regulate branching morphogenesis, stem cell fate, tissue differentiation and ...
Francesca Rochais, Robert G. Kelly
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Differentiation
Fibroblast growth factor 22 (FGF22) is a member of the FGF7 subfamily that functions as a paracrine factor and was identified in the human placenta in 2001. The FGF22 gene is located on human chromosome 19p13.3, mouse chromosome 10, and zebrafish chromosome 22 and is closely linked to the BSG, HCN2, and POLRMT genes. The gene is composed of three exons,
Rise, Furuta, Ayumi, Miyake
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Fibroblast growth factor 22 (FGF22) is a member of the FGF7 subfamily that functions as a paracrine factor and was identified in the human placenta in 2001. The FGF22 gene is located on human chromosome 19p13.3, mouse chromosome 10, and zebrafish chromosome 22 and is closely linked to the BSG, HCN2, and POLRMT genes. The gene is composed of three exons,
Rise, Furuta, Ayumi, Miyake
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Differentiation
Fibroblast growth factor 21 (FGF21) belongs to the FGF19 subfamily and acts systemically, playing a key role in inter-organ crosstalk. Ranging from metabolism, reproduction, and immunity, FGF21 is a pleiotropic hormone which contributes to various physiological processes.
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Fibroblast growth factor 21 (FGF21) belongs to the FGF19 subfamily and acts systemically, playing a key role in inter-organ crosstalk. Ranging from metabolism, reproduction, and immunity, FGF21 is a pleiotropic hormone which contributes to various physiological processes.
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Inhibition of fibroblast growth factors
Breast Cancer Research and Treatment, 1996The potential roles of members of the fibroblast growth factor family in tumor angiogenesis and metastasis and their mechanisms of release from cells are discussed. Furthermore, we review methods of therapeutic targeting of these polypeptides. In particular, we focus on the possibility to inhibit fibroblast growth factors with drugs that mimic heparin ...
A, Wellstein, F, Czubayko
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1996
Recent advances in the field of fibroblast growth factors (FGF) have led to a better understanding of their physiological functions and their roles in the pathogenesis of disease. In reviewing this field, we have concentrated on the numerous recent advances suggesting that these molecules are pivotal in embryonic development, reproduction, growth ...
Ann Logan, Andrew Baird
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Recent advances in the field of fibroblast growth factors (FGF) have led to a better understanding of their physiological functions and their roles in the pathogenesis of disease. In reviewing this field, we have concentrated on the numerous recent advances suggesting that these molecules are pivotal in embryonic development, reproduction, growth ...
Ann Logan, Andrew Baird
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1990
Growth factors are multifunctional (Sporn and Roberts 1988) and the family of fibroblast growth factors (FGFs) is a case in point. Although FGF activities have been known to exist in tissue extracts for almost half a century (Trowell et al. 1939; Hoffman 1940), it has only been in the last 10 years that these activities have been characterized and the ...
A. Baird, P. Böhlen
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Growth factors are multifunctional (Sporn and Roberts 1988) and the family of fibroblast growth factors (FGFs) is a case in point. Although FGF activities have been known to exist in tissue extracts for almost half a century (Trowell et al. 1939; Hoffman 1940), it has only been in the last 10 years that these activities have been characterized and the ...
A. Baird, P. Böhlen
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Fibroblast Growth Factor Receptor Inhibitors
Current Pharmaceutical Design, 2012Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates.
Suneel B V S, Kumar +4 more
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