Results 281 to 290 of about 1,940,282 (341)
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2003
We have reviewed data showing that FGFs are a family of related factors playing fundamental roles in several biologic processes involving tissue remodeling such as embryonic development, angiogenesis, wound healing, nerve regeneration, and chronic inflammation and cancer.
Ensoli, B +3 more
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We have reviewed data showing that FGFs are a family of related factors playing fundamental roles in several biologic processes involving tissue remodeling such as embryonic development, angiogenesis, wound healing, nerve regeneration, and chronic inflammation and cancer.
Ensoli, B +3 more
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The FASEB Journal, 1987
Fibroblast growth factors (FGFs) are heparin‐binding protein mitogens that induce division of most cultured cells derived from embryonic mesoderm and neuroectoderm. Terminally differentiated neurons also respond in vitro by eliciting outgrowth of neurites. In vivo, FGFs have been shown to induce DNA synthesis, cell migration, blood
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Fibroblast growth factors (FGFs) are heparin‐binding protein mitogens that induce division of most cultured cells derived from embryonic mesoderm and neuroectoderm. Terminally differentiated neurons also respond in vitro by eliciting outgrowth of neurites. In vivo, FGFs have been shown to induce DNA synthesis, cell migration, blood
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Receptors for fibroblast growth factors
Immunology & Cell Biology, 1995SummaryThe recent discovery of the involvement of heparan sulfate proteoglycans (HSPG) in the activation of fibroblast growth factor receptors (FGFR) has led to an intensification of study of this field. It appears that the HSPG act as low affinity receptors to which the fibroblast growth factors (FGF) must bind in order to successfully activate the ...
J C, Coutts, J T, Gallagher
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Fibroblast growth factor and hydrocephalus
Neurological Research, 2000The immunohistochemical localization of basic fibroblast growth factor (bFGF) was studied in ventricular ependyma and choroid plexus of aged-matched normotensive and spontaneously hypertensive rats at different ages using a polyclonal antibody against bFGF.
P, Cuevas, G, Giménez-Gallego
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2013
There is growing interest in the role of fibroblast growth factor 23 (FGF23) in various diseases of disordered mineral metabolism. In chronic kidney disease (CKD), where biochemical evidence of mineral disturbances is especially common, FGF23 measurement has been advocated as an early and sensitive marker for CKD-related bone disease.
Edward R, Smith +2 more
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There is growing interest in the role of fibroblast growth factor 23 (FGF23) in various diseases of disordered mineral metabolism. In chronic kidney disease (CKD), where biochemical evidence of mineral disturbances is especially common, FGF23 measurement has been advocated as an early and sensitive marker for CKD-related bone disease.
Edward R, Smith +2 more
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Differentiation
Fibroblast growth factor 10 (FGF10) is a major morphoregulatory factor that plays essential signaling roles during vertebrate multiorgan development and homeostasis. FGF10 is predominantly expressed in mesenchymal cells and signals though FGFR2b in adjacent epithelia to regulate branching morphogenesis, stem cell fate, tissue differentiation and ...
Francesca Rochais, Robert G. Kelly
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Fibroblast growth factor 10 (FGF10) is a major morphoregulatory factor that plays essential signaling roles during vertebrate multiorgan development and homeostasis. FGF10 is predominantly expressed in mesenchymal cells and signals though FGFR2b in adjacent epithelia to regulate branching morphogenesis, stem cell fate, tissue differentiation and ...
Francesca Rochais, Robert G. Kelly
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Fibroblast Growth Factor Prototype Release and Fibroblast Growth Factor Receptor Signaling
Thrombosis and Haemostasis, 1999A Brief Introduction to the Fibroblast Growth Factor Gene Family The fibroblast growth factor (FGF) family of genes presently comprise 18 members, including the two prototypes, FGF-1 (acidic) and FGF-2 (basic). Although the FGF prototypes are well described as mediators of a variety of diverse biological responses, such as mesoderm induction ...
R, Friesel, T, Maciag
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Differentiation
Fibroblast growth factor 22 (FGF22) is a member of the FGF7 subfamily that functions as a paracrine factor and was identified in the human placenta in 2001. The FGF22 gene is located on human chromosome 19p13.3, mouse chromosome 10, and zebrafish chromosome 22 and is closely linked to the BSG, HCN2, and POLRMT genes. The gene is composed of three exons,
Rise, Furuta, Ayumi, Miyake
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Fibroblast growth factor 22 (FGF22) is a member of the FGF7 subfamily that functions as a paracrine factor and was identified in the human placenta in 2001. The FGF22 gene is located on human chromosome 19p13.3, mouse chromosome 10, and zebrafish chromosome 22 and is closely linked to the BSG, HCN2, and POLRMT genes. The gene is composed of three exons,
Rise, Furuta, Ayumi, Miyake
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Fibroblast Growth Factors and Neuroprotection
2003Several members of the FGF family, in particular FGF2, are intimately involved in neuronal protection and repair after ischemic, metabolic or traumatic brain injury. Expression of Fgf2 mRNA and protein is strongly upregulated after neuronal damage, with glial cells as the predominant source.
Christian, Alzheimer, Sabine, Werner
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Thrombin inactivates acidic fibroblast growth factor but not basic fibroblast growth factor
Biochemistry, 1988Incubation of bovine brain derived acidic fibroblast growth factor (aFGF) with bovine or human thrombin, 0.5 NIH unit/mL, for 24 h at 37 degrees C results in cleavage of the mitogen, generating a 14-kilodalton fragment which has significantly reduced affinity for immobilized heparin as compared to aFGF, and is at least 50-fold less potent at ...
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