Results 51 to 60 of about 3,826 (203)
eLife, 2019 We respond to concerns expressed by Pacifici and Shore (2019) about a recent paper (Lees-Shepard and Goldhamer, 2018a) in which we reported that the drug palovarotene can have severe side effects in a mouse model of fibrodysplasia ossificans progressiva.
David J Goldhamer, John B Lees-Shepard
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Patient Retreat in Dose Escalation for Phase I Clinical Trials With Rare Diseases
Statistics in Medicine, Volume 45, Issue 3-5, February 2026.ABSTRACT Phase I clinical trials aim to identify the maximum tolerated dose (MTD), a task that becomes challenging in rare disease due to limited patient recruitment. Traditional dose‐finding designs, which assign one dose per patient, require a sufficient sample size that may be infeasible for rare disease trials.
Jialu Fang, Guosheng Yin
wiley +1 more source
Fibrodysplasia Ossificans Progressiva - An Uncommon Cause of Trismus
Indian Journal of Physical Medicine & Rehabilitation, 2022 Fibrodysplasia ossificans progressiva (FOP) is a progressively disabling genetic disorder. It is characterised by development of a secondary skeleton due to progressive hypertrophic ossification.
Ravi Sankaran +2 more
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گزارش 1 مورد بيمار مبتلا به فيبروديسپلازی(ميوزيت) اسيفيکان پيشرونده [PDF]
, 2003 فيبروپلازی(ميوزيت) اسيفيکان پيشرونده بيماری نادر بافت همبند میباشد که مشخصه آن استخوانسازی نابجا در نسج نرم و بطور منتشر در تمام بدن و هالوکس والگوس دوطرفه هيپوپلاستيک(انگشت شست کوچک در پا) میباشد.
شيرانی, فاطمه
core
Fibrodysplasia ossificans progressiva: a case report [PDF]
, 2017 Fibrodysplasia Ossificans Progressiva is a rare debilitating disorder of the musculoskeletal system affecting one in two million individuals. It is characterized by progressive extraskeletal ossification of soft tissues resulting in the original skeleton
Baidoo, Richard O., Dayie, Makafui S.
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The Scientific Case for Animal Models: A Perspective From Musculoskeletal Researchers
FASEB BioAdvances, Volume 8, Issue 2, February 2026.ABSTRACT The National Institutes of Health (NIH) has launched a major initiative to expand human‐based New Approach Methodologies (NAMs) in biomedical research and reduce reliance on animal models. While NAMs offer powerful complementary tools, animal‐based research remains indispensable in musculoskeletal science for understanding complex cellular and
Michael Hadjiargyrou +4 more
wiley +1 more source
Stem Cell Reports, 2018 Summary: Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disorder characterized by extraskeletal bone formation through endochondral ossification.
Kyosuke Hino +10 more
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Early stage fibrodysplasia ossificans progressiva: A case report
Radiology Case Reports, 2020 Fibrodysplasia ossificans progressiva is a very rare autosomal dominant genetic connective tissue disease with a progressive ectopic ossification of muscle (intramuscular) or perimuscular connective tissue such as tendons or joint capsules.
Achmad Fauzi Kamal, MD,PhD +1 more
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Clinical Features, Diagnosis and Management of Fibrodysplasia Ossificans Progressiva
罕见病研究, 2023 Fibrodysplasia ossificans progressiva(FOP) is a rare congenital disease characterized by progressive heterotopic ossification, causing severe immobility with multi-system involvement.
ZHAO Junduo, SHEN Jianxiong
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Osseous metaplasia in an ulcerating tubular adenoma of the colon: a case report [PDF]
, 2008 Introduction Heterotopic bone is rarely found in the gastrointestinal tract. Here we report a rare case of metaplastic ossification within a benign ulcerating adenoma and review the literature concerning the aetiology.
Victoria White +19 more
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