Results 81 to 90 of about 3,826 (203)

Fibrodysplasia Ossificans Progressiva: A Case Report

Journal of Orthopaedic Surgery, 2013
Fibrodysplasia ossificans progressiva or myositis ossificans is a rare disease characterised by bony deposits or the ossification of soft tissues. It transforms skeletal muscles, tendons, ligaments, fascia, and aponeuroses into heterotopic bony deposits ...
Anoop C Dhamangaonkar, Akhil A Tawari, Arvind B Goregaonkar   +2 more
doaj   +1 more source

Fibrodysplasia ossificans progressiva: a comprehensive review [PDF]

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder that causes heterotopic ossification of soft tissues, leading to abnormal bone growth in muscles, tendons, and ligaments.
A., Subhashini, R. V., Raveena, S., Tamilselvan   +2 more
core   +2 more sources

ECSIT‐X4 is Required for Preventing Pressure Overload‐Induced Cardiac Hypertrophy via Regulating Mitochondrial STAT3

Advanced Science, Volume 12, Issue 8, February 24, 2025.
ECSIT‐X4 is the predominant cardiac isoform of ECSIT, encoded by the Ecsit‐X4 transcript variant in adult cardiomyocytes. The splicing junction of exon 9 generates the mouse Ecsit‐X4 isoform, resulting in a recognizable C‐terminal sequence. It is shown that ECSIT‐X4 interacts with STAT3, enhancing the activity of complex I, thereby promoting ...
Xia Lu, Tingting Tong, Haoliang Sun, Yi Chen, Yongfeng Shao, Pengxi Shi, Linli Que, Li Liu, Guoqing Zhu, Qi Chen, Chuanfu Li, Jiantao Li, Shuo Yang, Yuehua Li   +13 more
wiley   +1 more source

The Hedgehog–GLI1 Pathway Regulates Osteogenic Differentiation of Human Cervical Posterior Longitudinal Ligament Cells by BMP Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Cervical ossification of the posterior longitudinal ligament (OPLL) is an ectopic ossification disorder characterised by endochondral ossification. Its aetiology remains to be fully elucidated. This study aimed to clarify its pathogenesis through RNA sequencing of primary cells cultured from patients without cervical OPLL (control, PLL) and ...
Wenbo Xu, Bingbing Ran, Toshimi Aizawa, Wanguo Liu, Jianhui Zhao, Renrui Niu, Zeping Liu, Rui Gu   +7 more
wiley   +1 more source

Enhanced BMP Signaling Alters Human β‐Cell Identity and Function

Advanced Biology, Volume 9, Issue 1, January 2025.
This study evaluates the association between bone morphogenetic protein (BMP)‐signaling and inflammation‐induced β‐cell failure in the context of diabetes. Results show that proinflammatory cytokines activate BMP signaling in human islets. Furthermore, enhanced BMP signaling reduces β‐cell marker expression, increases ER stress, and impairs β‐cell ...
Esmée Dekker, Javier Triñanes, Amadeo Muñoz Garcia, Natascha de Graaf, Eelco de Koning, Françoise Carlotti   +5 more
wiley   +1 more source

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome

Frontiers in Endocrinology, 2020
Segmental progeroid syndromes are commonly represented by genetic conditions which recapitulate aspects of physiological aging by similar, disparate, or unknown mechanisms.
Robert J. Pignolo, Robert J. Pignolo, Robert J. Pignolo, Haitao Wang, Haitao Wang, Haitao Wang, Frederick S. Kaplan, Frederick S. Kaplan, Frederick S. Kaplan   +8 more
doaj   +1 more source

Fibrodysplasia Ossificans Progressiva: treatment and oral considerations [PDF]

, 2018
Treball Final de Grau d'Odontologia, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Curs: 2017-2018, Director: Francesc Ventura PujolFibrodysplasia ossificans progressiva (FOP) is a rare disease with a worldwide prevalence of one ...
Gutiérrez Nava, María Gabriela
core  

Spatiotemporal Analysis of Mesenchymal Stem Cells Fate Determination by Inflammatory Niche Following Soft Tissue Injury at a Single‐Cell Level

Advanced Science, Volume 11, Issue 43, November 20, 2024.
The dynamics of mesenchymal stem cell (MSC) lineage specification and associated dynamic regulation is highlighted by immune cells during HO formation, i.e., an elaborate trajectory of MSCs is characterized during aberrant osteochondrogenesis and demonstrates that MSCs proliferation are regulated by M1 macrophages (M1), neutrophils, and natural killer (
Chen Kan, Zhenya Tan, Haitao Wang, Wei Wang, Jiazhao Yang, Ya Zhang, Xiaoling Lu, Qirong Cheng, Lanyi Chai, Chao Peng, Jicheng Zhu, Chenghang Zhu, Hailin Wang, Li Zhan, Keqiong Lin, Yakun Liu, Lingqiang Zhang, Haitao Fan, Hong Zheng   +18 more
wiley   +1 more source

When Problems Become Solutions: Harnessing the Osteogenic Capacity of Disease-Causing Stem Cells to Repair Bone Fractures [PDF]

, 2022
While we often perceive disease as negative, there is potential to engineer seemingly negative biological phenomena into therapeutics to treat a variety of human illnesses.
Pasha, Mehreen
core   +2 more sources

Fibrodysplasia ossificans progressiva.

JPMA. The Journal of the Pakistan Medical Association, 2011
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder of the connective tissue characterized by progressive disability as a result of extensive extra skeletal enchondral bone formation and malformed big toes which are often monophalangic.
Nadia, Shaikh, Fehmina, Arif
openaire   +3 more sources