Results 31 to 40 of about 196,664 (232)

Development and Differentiation in Monobodies Based on the Fibronectin Type 3 Domain

Cells, 2020
As a non-antibody scaffold, monobodies based on the fibronectin type III (FN3) domain overcome antibody size and complexity while maintaining analogous binding loops.
Peter G. Chandler, Ashley M. Buckle
doaj   +1 more source

Sandblasting and fibronectin-derived peptide immobilization on titanium surface increase adhesion and differentiation of osteoblast-like cells (MC3T3-E1)

Journal of Dental Sciences, 2016
Background/purpose: Various chemical titanium (Ti) surface modifications have been reported for enhancing cellular activities that promote early osseointegration.
Samdharu Pramono, Kamolparn Pugdee, Jintamai Suwanprateep, Sittichai Koontongkaew   +3 more
doaj   +1 more source

Association of left ventricular structural remodeling types with fibronectin deficiency in patients with multivessel coronary artery disease

Российский кардиологический журнал, 2023
Aim. To evaluate the serum fibronectin level in patients with multivessel coronary artery disease, and to identify the relationship of fibronectin level with atrial fibrillation (AF) developed in the hospital after coronary artery bypass grafting (CABG ...
A. R. Mingalimova, N. G. Gumanova, N. M. Bikbova, O. N. Dzhioeva, M. S. Pokrovskaya, I. A. Efimova, Z. Z. Serebryanskaya, N. L. Bogdanova, A. L. Borisova, O. M. Drapkina   +9 more
doaj   +1 more source

Silk Fibroin Nanoparticles Functionalized with Fibronectin for Release of Vascular Endothelial Growth Factor to Enhance Angiogenesis

Journal of Natural Fibers, 2022
This work aimed at enhancing the angiogenesis in the presence of silk fibroin nanoparticles functionalized with fibronectin (FN-SF NPs) for controlled release of vascular endothelial growth factor (VEGF).
Payam Zahedi, Negar Hassani Besheli, Mehdi Farokhi, Fatemeh Mottaghitalab, Amin Sohrabi, Sohrab Ali Ghorbanian   +5 more
doaj   +1 more source

Collagen Assembly at the Cell Surface: Dogmas Revisited

Cells, 2021
With the increased awareness about the importance of the composition, organization, and stiffness of the extracellular matrix (ECM) for tissue homeostasis, there is a renewed need to understand the details of how cells recognize, assemble and remodel the
Moses Musiime, Joan Chang, Uwe Hansen, Karl E. Kadler, Cédric Zeltz, Donald Gullberg   +5 more
doaj   +1 more source

Commonly used anti–von Willebrand factor antibody for multimer analysis cross‐reacts with fibronectin, which is difficult to distinguish from von Willebrand factor

Research and Practice in Thrombosis and Haemostasis, 2021
Von Willebrand factor (VWF) is a 500‐ to 15 000‐kDa multimeric protein circulating in the blood. When VWF has a higher molecular weight, its hemostatic activity is greater.
Yuka Eura, Koichi Kokame
doaj   +1 more source

RNA-Seq Analysis of Extradomain A and Extradomain B Fibronectin as Extracellular Matrix Markers for Cancer

Cells, 2023
Alternatively spliced forms of fibronectin, called oncofetal fibronectin, are aberrantly expressed in cancer, with little to no expression in normal tissue, making them attractive biomarkers to exploit for tumor-targeted therapeutics and diagnostics ...
Ryan C. Hall, Amita M. Vaidya, William P. Schiemann, Quintin Pan, Zheng-Rong Lu   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Aspirin Inhibits Fibronectin Expression and Reverses Fibronectin-Mediated Cell Invasiveness by Activating Akt Signaling in Preeclampsia

Pharmaceuticals, 2022
Preeclampsia is a severe gestational hypertensive disorder that may lead to maternal multiple organ dysfunction and adverse fetal outcomes. Aspirin provides a protective effect by reducing the risk of preeclampsia; however, its mechanism of action is ...
Mei-Tsz Su, Ching-Wei Tsai, Pei-Yin Tsai, Chia-Yih Wang, Hui-Ling Tsai   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source