Results 41 to 50 of about 1,902,157 (395)

Genome-wide DNA methylation dynamics in carbon tetrachloride-induced mice liver fibrosis [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Many persistent harmful stimuli can result in chronic liver diseases, which lead to about 2 million deaths per year in the whole world. Liver fibrosis was found to exist in all kinds of chronic liver diseases.
Deming Li, Xiaoshu Guo, Wenyu Zhao, Jingyu Chen, Cong Xia, Guoying Yu   +5 more
doaj   +1 more source

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. [PDF]

, 2015
Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant in mouse and human CP.
Chawla, Ajay, Habtezion, Aida, Hsieh, Michael H, Murali, Ramachandran, Pandol, Stephen J, Sharma, Vishal, Xue, Jing   +6 more
core   +2 more sources

Elevated sweat chloride test: is it always cystic fibrosis?

Italian Journal of Pediatrics, 2021
Background The sweat chloride test (ST) is the gold standard for cystic fibrosis (CF) diagnosis in symptomatic patients, within the newborn screening and in the follow-up of CF patients during molecular therapies.
C. Cimbalo, A. Tosco, V. Terlizzi, A. Sepe, A. Castaldo, L. Salvadori, V. Raia   +6 more
doaj   +1 more source

M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes. [PDF]

, 2017
Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults.
Bai, Li, Chen, Yu, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Kong, Ming, Liu, Shuang, Liu, Xin, Lou, Jinli, Pandol, Stephen J, Ren, Feng, Zhang, Xiaohui, Zheng, Qingfen, Zheng, Sujun   +13 more
core   +2 more sources

Upregulation of a CFTR mRNA isoform has therapeutic potential for the treatment of 3′ CFTR PTC variants

Molecular Therapy: Nucleic Acids
Nonsense or premature termination codon (PTC) variants of the CFTR gene are pathogenic and found in ∼10% of North American people with cystic fibrosis.
Normand E. Allaire, Matthew S. Armstrong, Jae Seok Yoon, Mercy C. Walker, Priyanka Bhatt, Jan M. Harrington, Yi Cheng, Eric I. Wong, John E. Mahoney, Hillary C. Valley, Caitlin M. Macadino, Hermann J. Bihler, Andrey Y. Sivachenko, Calvin U. Cotton, John P. Carulli, Martin Mense   +15 more
doaj   +1 more source

REAL‐world clinical effectiveness of ivacaftor therapy in the first 24 months in two infants with cystic fibrosis and different gating mutations—A case report

Clinical Case Reports, 2022
This study summarizes efficacy of ivacaftor treatment in 2 infants in a real‐world setting. A distinct decline of sweat chloride and lung clearance index plus increase in fecal elastase was seen. The results underline the early and sustainable effect and
Teresa Fuchs, Dorothea Appelt, Katharina Niedermayr, Helmut Ellemunter   +3 more
doaj   +1 more source

Cystic Fibrosis Foundation and European Cystic Fibrosis Society Survey of cystic fibrosis mental health care delivery [PDF]

, 2015
Background: Psychological morbidity in individuals with cystic fibrosis (CF) and their caregivers is common. The Cystic Fibrosis Foundation (CFF) and European Cystic Fibrosis Society (ECFS) Guidelines Committee on Mental Health sought the views of CF ...
A.L. Quittner, A.M. Georgiopoulos, B.A. Smith, B.C. Marshall, Boyle, Braun, Clarke, DiMatteo, Fidika, Foy, Foy, Godfrey, Havermans, Health Disorders, J. Abbott, J.S. Elborn, K.A. Sabadosa, L. Goldbeck, Lewiston, Manfreda, Mitchell, Monkey, Moussavi, National Collaborating Centre For Mental Health (UK), National Collaborating Centre for Mental Health (UK), Nulty, Quittner, Riekert, Sawicki, Shih, Smith, Snell, Stern, West   +33 more
core   +1 more source

A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis.

New England Journal of Medicine
BACKGROUND Nonalcoholic steatohepatitis (NASH) is a progressive liver disease with no approved treatment. Resmetirom is an oral, liver-directed, thyroid hormone receptor beta-selective agonist in development for the treatment of NASH with liver fibrosis.
Stephen A. Harrison, P. Bedossa, Cynthia Guy, J. Schattenberg, Rohit Loomba, R. Taub, D. Labriola, S. Moussa, Guy W. Neff, M. Rinella, Q. Anstee, M. Abdelmalek, Z. Younossi, S. Baum, Sven M. Francque, Michael R. Charlton, Philip N. Newsome, N. Lanthier, Ingolf Schiefke, Alessandra Mangia, J. M. Pericàs, Rashmee Patil, Arun J. Sanyal, M. Noureddin, Meena B Bansal, N. Alkhouri, Laurent Castera, Madhavi Rudraraju, V. Ratziu   +28 more
semanticscholar   +1 more source

Pleural Fibrosis

Clinics in Chest Medicine, 2006
Pleural fibrosis can result from a variety of inflammatory processes. The response of the pleural mesothelial cell to injury and the ability to maintain its integrity are crucial in determining whether normal healing or pleural fibrosis occurs.
Division of Pulmonary and Critical Care Medicine, University of Florida SW Archer Road, Room M352, PO Box 100225, Gainesville, FL 32610–0225, USA ( host institution ), Jantz, Michael A. ( author ), Antony, Veena B. ( author )   +2 more
openaire   +3 more sources

Magnetic resonance tumor regression grade (MR-TRG) to assess pathological complete response following neoadjuvant radiochemotherapy in locally advanced rectal cancer [PDF]

, 2017
This study aims to evaluate the feasibility of a magnetic resonance (MR) automatic method for quantitative assessment of the percentage of fibrosis developed within locally advanced rectal cancers (LARC) after neoadjuvant radiochemotherapy (RCT). A total
Bellini, D, Caruso, D, Caterino, Martina, Ciolina, M, De Santis, D, Laghi, A., Marzi, S, Musio, Daniela, Picchia, S, Rengo, M, Tombolini, V   +10 more
core   +1 more source