Results 41 to 50 of about 1,287,697 (363)
Targeted therapies to improve CFTR function in cystic fibrosis [PDF]
, 2015 Cystic fibrosis is the most common genetically determined, life-limiting disorder in populations of European ancestry. The genetic basis of cystic fibrosis is well established to be mutations in the cystic fibrosis transmembrane conductance regulator ...
Brodlie, M +3 more
core +2 more sources
Fibro-CoSANet: Pulmonary Fibrosis Prognosis Prediction using a Convolutional Self Attention Network [PDF]
, 2021 Idiopathic pulmonary fibrosis (IPF) is a restrictive interstitial lung disease that causes lung function decline by lung tissue scarring. Although lung function decline is assessed by the forced vital capacity (FVC), determining the accurate progression of IPF remains a challenge. To address this challenge, we proposed Fibro-CoSANet, a novel end-to-end
arxiv +1 more source
Contrast-free detection of myocardial fibrosis in hypertrophic cardiomyopathy patients with diffusion-weighted cardiovascular magnetic resonance. [PDF]
, 2015 BackgroundsPrevious studies have shown that diffusion-weighted cardiovascular magnetic resonance (DW-CMR) is highly sensitive to replacement fibrosis of chronic myocardial infarction. Despite this sensitivity to myocardial infarction, DW-CMR has not been
Bi, Xiaoming +6 more
core +2 more sources
Characterizing Pulmonary Fibrosis Patterns in Post-COVID-19 Patients through Machine Learning Algorithms [PDF]
arXiv, 2023 The COVID-19 pandemic has left a lasting impact on global healthcare systems, with increasing evidence of pulmonary fibrosis emerging as a post-infection complication. This study presents a comprehensive analysis of pulmonary fibrosis patterns in post-COVID-19 patients from South and Central Iraq, employing advanced machine learning algorithms.
arxiv
Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing. [PDF]
, 2017 Fibrotic diseases contribute to 45% of deaths in the industrialized world, and therefore a better understanding of the pathophysiological mechanisms underlying tissue fibrosis is sorely needed.
Amatucci, Aldo +16 more
core +2 more sources
American Journal of Respiratory and Critical Care Medicine, 2013 To the Editor: Recent efforts in cellular reprogramming to repair injured organs have focused particularly on fibroblasts (1). As fibroblasts are key effector cells in the development of fibrosis, this seems a rational approach. However, we wonder whether, in addition to fibroblasts, the contribution of another cell type may be critical to ...
Cara J. Gottardi, Anna P. Lam
openaire +3 more sources
IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice [PDF]
, 2014 Background<p></p> The initiation and regulation of pulmonary fibrosis are not well understood. IL-33, an important cytokine for respiratory diseases, is overexpressed in the lungs of patients with idiopathic pulmonary fibrosis.<p>< ...
Besnard, Anne-Gaëlle +10 more
core +3 more sources
Multiphase modeling of tumor growth with matrix remodeling and fibrosis [PDF]
Math. Comput. Modelling, 52(7-8):969-976, 2010, 2009 We present a multiphase mathematical model for tumor growth which incorporates the remodeling of the extracellular matrix and describes the formation of fibrotic tissue by tumor cells. We also detail a full qualitative analysis of the spatially homogeneous problem, and study the equilibria of the system in order to characterize the conditions under ...
arxiv +1 more source
Frontiers in Cellular and Infection Microbiology, 2011 IntroductionOrganisms of the Burkholderia cepacia complex (BCC) are important pathogens in cystic fibrosis (CF). The majority of those who acquire BCC develop chronic infection but it can also result in rapid decline in a significant minority.
Alex eHorsley +7 more
doaj +1 more source
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Nature Communications, 2021 Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination ...
Jyoti Sharma +29 more
doaj +1 more source