Results 81 to 90 of about 607,838 (295)

Pulmonary Fibrosis [PDF]

, 2005
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease limited to the lungs and associated with the histologic appearance of usual interstitial pneumonia (UIP) on surgical lung biopsy. The estimated prevalence in the United States is between 35,000 and 55,000 cases,and evidence suggests that the prevalence is increasing for IPF.
Zisman, David A., Keane, Michael P., Belperio, John A., Strieter, Robert M., Lynch, Joseph P.   +4 more
openaire   +2 more sources

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Clinical complications in children with false-negative results in cystic fibrosis newborn screening

Jornal de Pediatria, 2022
Objective: To present signs and symptoms and clinical course in cystic fibrosis patients with false-negative newborn screening (CF NBS). Materials and methods: All children presented in this paper were covered by CF NBS.
Katarzyna Zybert, Urszula Borawska-Kowalczyk, Lukasz Wozniacki, Malwina Dawidziuk, Mariusz Ołtarzewski, Dorota Sands   +5 more
doaj  

Editorial - Mediators of Fibrosis [PDF]

The Open Rheumatology Journal, 2012
Progressive, uncontrolled deposition of extracellular matrix proteins leading to scar tissue formation and organ failure represents a final common pathway of tissue response to chronic injury. The nature of the insult varies between organs and tissues and may include viral infections or toxic agents, but in most cases the specific trigger remains ...
openaire   +3 more sources

Machine learning based radiomics model to predict radiotherapy induced cardiotoxicity in breast cancer

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Cardiotoxicity is one of the major concerns in breast cancer treatment, significantly affecting patient outcomes. To improve the likelihood of favorable outcomes for breast cancer survivors, it is essential to carefully balance the potential advantages of treatment methods with the risks of harm to healthy tissues, including the heart.
Amin Talebi, Ahmad Bitarafan‐Rajabi, Azin Alizadeh‐asl, Parisa Seilani, Benyamin Khajetash, Ghasem Hajianfar, Meysam Tavakoli   +6 more
wiley   +1 more source

Impact of Achromobacter xylosoxidans isolation on the respiratory function of adult patients with cystic fibrosis

ERJ Open Research, 2019
Background The prevalence of Achromobacter xylosoxidans lung isolation in cystic fibrosis (CF) patients has increased, but the impact on lung function is controversial. The aim of this study was to evaluate the long-term effects of A.
Macha Tetart, Frederic Wallet, Maeva Kyheng, Sylvie Leroy, Thierry Perez, Olivier Le Rouzic, Benoit Wallaert, Anne Prevotat   +7 more
doaj   +1 more source

Investigation of factors related to treatment planning of x‐ray SBRT and scanning carbon‐ion radiation therapy for early‐stage lung cancer patients

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract This study aimed to compare the treatment plans of x‐ray SBRT and scanning carbon ion radiation therapy (CIRT) for localized lung tumors, and to evaluate the dose dependence of tumor size tumor‐to‐heart distance. For phantom verification, we used a chest phantom with a spherical simulated tumor.
Yuya Miyasaka, Sung Hyun Lee, Hikaru Souda, Hongbo Chai, Miyu Ishizawa, Takuya Ono, Takashi Ono, Hiraku Sato, Takeo Iwai   +8 more
wiley   +1 more source

F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway

Molecular Medicine
Background Skin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The latency-associated peptide (LAP) is essential for TGF-β1 activation.
Zhiqin Cao, Keke Zhang, Jingruo Liu, Yu Pan, Jiayi Shi, Luxin Li, Xiaocan Sun, Shiqi Li, Xiaohuan Yuan, Dan Wu   +9 more
doaj   +1 more source

A non-randomised single centre cohort study, comparing standard and modified bowel preparations, in adults with cystic fibrosis requiring colonoscopy

BMC Gastroenterology, 2019
Background Adults with cystic fibrosis (CF) have been reported to be at five to ten-fold risk (25 to 30 fold risk after solid organ transplant) of colorectal cancer (CRC) than the general population.
A. G. Matson, J. P. Bunting, A. Kaul, D. J. Smith, J. Stonestreet, K. Herd, R. S. Hodgson, S. C. Bell   +7 more
doaj   +1 more source

Quantitative beam optimization for radiotherapy of peripheral lung lesions: A pilot study in stereotactic body radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background To quantify beam optimization for stereotactic body radiotherapy (SBRT) of peripheral lung lesions. Method The new beam optimization approach was based on maximizing the therapeutic gain (TG) of the beam set by minimizing the average physical depth of the lesion with respect to the beam's eye view (BEV).
Hamed Hooshangnejad, Jina Lee, Leslie Bell, Russell K. Hales, Khinh Ranh Voong, Sarah Han‐Oh, Kai Ding, Reza Farjam   +7 more
wiley   +1 more source