Results 101 to 110 of about 5,472 (201)
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Qiuyan Ye +10 more
wiley +1 more source
Complement and transplant‐associated thrombotic microangiopathy: Current and future approaches
HemaSphere, Volume 10, Issue 4, April 2026.
Massimo Cugno +2 more
wiley +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Kehinde Sunmboye, Pauline Millan
wiley +1 more source
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 1, January 2026.This study combined network pharmacology, molecular docking, and in vitro (HepG2) and in vivo (T2DM mice) experiments to investigate sinapine's effect on insulin resistance. Sinapine was found to modulate the IRS1–PI3K–AKT–GSK3β–GS pathway. In vitro, sinapine improved glucose uptake, enhanced glycogen synthesis, and reduced lipogenesis and ROS. In vivo,
Tiancheng Xing +9 more
wiley +1 more source
Differential Role of the Lectin Pathway of Complement Activation in Susceptibility to Neonatal Sepsis [PDF]
, 2017 Background. The incidence of bacterial sepsis during the neonatal period is high. Mannan-binding lectin (MBL), L-ficolin, and H-ficolin recognize microorganisms and activate the complement system viaMBL-associated serine proteases (MASPs).
Boillat, Colette +8 more
core
, 2009 Histidine-rich glycoprotein (HRG) is an abundant multi-functional protein that is present in the plasma of many vertebrates. HRG has a multi-domain structure that allows the molecule to interact with many ligands including heparin, heparan sulfate (HS ...
Poon, Ivan Ka Ho
core +1 more source
A high confidence, manually validated human blood plasma protein reference set [PDF]
, 2008 BACKGROUND: The immense diagnostic potential of human plasma has prompted great interest and effort in cataloging its contents, exemplified by the Human Proteome Organization (HUPO) Plasma Proteome Project (PPP) pilot project.
Susann Schenk +29 more
core +2 more sources
The Lectin Pathway of Complement and Rheumatic Heart Disease
Frontiers in Pediatrics, 2015 The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.
Marcia Holsbach Beltrame +4 more
doaj +1 more source
Association of low ficolin-lectin pathway parameters with Cardiac Syndrome X [PDF]
, 2016 In patients with typical angina pectoris, inducable myocardial ischaemia and macroscopically normal coronaries (Cardiac Syndrome X, CSX) significantly elevated plasma level of terminal complement complex (TCC), the common end-product of complement ...
Agrawal +48 more
core +1 more source