Results 81 to 90 of about 5,472 (201)

A novel assay to quantitate MASP-2/ficolin-3 complexes in serum

Immunobiology, 2012
Ficolin-1, -2 and -3 are recognition molecules in the lectin complement pathway and form complexes with serine proteases named MASP-1, -2 and -3 and two nonenzymatic proteins. MASP-2 is the main initiator of lectin pathway activation, while ficolin-3 is the most abundant ficolin molecule in the circulation.
Csuka, Dorottya, Munthe-Fog L, Skjoedt MO, Hein E, Bay JT, Varga, Lilian, Füst, György, Garred P   +7 more
openaire   +3 more sources

Comprehensive Analysis of Prognostic Value and Immune Infiltration of Ficolin Family Members in Hepatocellular Carcinoma

Frontiers in Genetics, 2022
Objective: Ficolin (FCN) family proteins are part of the innate immune system, play a role as recognition molecules in the complement system, and are associated with tumor development.
Liang Sun, Shian Yu, Cairong Dong, Zhengyi Wu, He Huang, Zhendong Chen, Zhipeng Wu, Xiangbao Yin   +7 more
doaj   +1 more source

MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors. [PDF]

, 2016
It had been thought that complement factor D (FD) is activated at the site of synthesis, and only FD lacking a propeptide is present in blood. The serum of mannose-binding lectin-associated serine protease (MASP)-1/3(-/-) mice contains pro-FD and has ...
Andrea Kocsis, Anne Zeck, Dávid Szakács, Elod Kortvely, Gábor Oroszlán, Gábor Pál, József Dobó, Marius Ueffing, Péter Gál, Péter Závodszky, Sascha Dammeier   +10 more
core   +1 more source

H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates

Immunobiology, 2012
Serum H-ficolin (ficolin-3) concentrations (n=613) and FCN3 genotypes (n=529) from a large group of neonates are presented. Both pre-term deliveries and low birthweight (independently of gestational age) were significantly associated with low H-ficolin concentrations but not with heterozygosity for the FCN3 1637delC frameshift mutation. The presence of
Mateusz, Michalski, Agnieszka, Szala, Anna, St Swierzko, Jolanta, Lukasiewicz, Anna, Maciejewska, David C, Kilpatrick, Misao, Matsushita, Iwona, Domzalska-Popadiuk, Monika, Borkowska-Klos, Anna, Sokolowska, Jerzy, Szczapa, Czeslaw, Lugowski, Maciej, Cedzynski   +12 more
openaire   +2 more sources

Yersinia enterocolitica O:3 Outer Membrane Vesicles as a Platform for Complement Activation

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Basic characteristics and biological activity of outer membrane vesicles (OMVs) secreted by Yersinia enterocolitica O:3 (YeO3), depending on LPS chemotype and growth temperature. ABSTRACT Lipopolysaccharide (LPS) is the major component of the outer membrane vesicles (OMVs) of Gram‐negative bacteria.
Cédric Battaglino, Iryna Bodnaruk, Paula Czyszczoń, Mikael Skurnik, Beata Filip‐Psurska, Dariusz Jarych, Anna Maciejewska, Mariusz Gadzinowski, Kamil Malik, Izabela Potocka, Paweł Migdał, Roksana Kruszakin, Maciej Cedzyński, Katarzyna Kasperkiewicz, Jolanta Lukasiewicz, Anna S. Świerzko   +15 more
wiley   +1 more source

Proteomic analysis of mare follicular fluid during late follicle development [PDF]

, 2010
Background: Follicular fluid accumulates into the antrum of follicle from the early stage of follicle development. Studies on its components may contribute to a better understanding of the mechanisms underlying follicular development and oocyte quality ...
Jean-Louis Dacheux, Nadine Gérard, Somayyeh Fahiminiya, Stéphane Roche, Valérie Labas   +4 more
core   +4 more sources

Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Proteomic profiling of tissue explant‐ and plasma‐derived extracellular vesicles identified colon adenocarcinoma‐associated and healthy‐associated EV proteins. A 10‐protein EV panel enabled highly sensitive blood‐based detection of colon adenocarcinoma, showed marked postoperative changes, and retained performance in an independent validation cohort ...
Yura Seo, Yoon Dae Han, Linda Bojmar, Kyung‐A Kim, Yurin Seo, Taeyul K. Kim, Suho Lee, Yeleem Kim, Hye Bin Choi, Yujin H. Lim, Chae Hyun Kim, Alexander Sandberg, Chuanwen Fan, Pernille Lauritzen, Henrik Molina, Christopher Peralta, Jacob B. Geri, Colin Burdette, Dai Hoon Han, Heon Yung Gee, Insuk Lee, Jeon‐Soo Shin, Hyunwook Kim, Leon Li, Gabriel C. Tobias, Inbal Wortzel, Sang Joon Shin, Hyo‐Il Jung, Min Goo Lee, Soonmyung Paik, Robert E. Schwartz, Joong Bae Ahn, David Lyden, Han Sang Kim   +33 more
wiley   +1 more source

Biomarker development for presymptomatic molecular diagnosis of preeclampsia: Feasible, useful or even unnecessary? [PDF]

, 2015
The past decade saw the advent of a number of promising biomarkers to detect pregnancies at risk for preeclampsia (PE), the foremost being those associated with an imbalance of angiogenic factors.
Hahn, S., Lapaire, O., Than, Nándor Gábor   +2 more
core   +2 more sources

Therapeutic Potential of Lentiviral miR‐200a Mimics in Regulating Fibrinolysis and EMT Markers During Pulmonary Fibrosis

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
The graphical abstract contrasts normal and fibrotic lungs, illustrating how miR‐200a mimics suppress PAI‐1 and EMT markers, restore fibrinolysis, and reduce MMP‐driven ECM deposition. This schematic highlights the therapeutic potential of miR‐200a in mitigating pulmonary fibrosis progression.
T. M. Jeena, C. Rakshitha, Akarsha B. Jain, Vaishnavi, Fathima Razana, Aleena Varughese, M. Fathimath Muneesa, Yashodhar P. Bhandary   +7 more
wiley   +1 more source

Plasma Proteomic Profiles of Cerebrospinal Fluid-Defined Alzheimer's Disease Pathology in Older Adults. [PDF]

, 2017
Cerebrospinal fluid (CSF) biomarkers of the beta-amyloid and microtubule associated protein tau metabolism have proven the capacity to improve classification of subjects developing Alzheimer's disease (AD).
Bowman, G.L., Cominetti, O., Corthésy, J., Dayon, L., Henry, H., Migliavacca, E., Núñez Galindo, A., Oikonomidi, A., Popp, J., Wojcik, J.   +9 more
core   +2 more sources