Results 61 to 70 of about 5,472 (201)

Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism [PDF]

, 2017
Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced via limited proteolysis by another protease or by autoactivation.
Dani, Ráhel, Dobó, József, Gál, Péter, Oroszlán, Gábor, Szilágyi, András, Thiel, Steffen, Závodszky, Péter   +6 more
core   +2 more sources

Inflammation: an important parameter in the search of prostate cancer biomarkers [PDF]

, 2014
Background A more specific and early diagnostics for prostate cancer (PCa) is highly desirable. In this study, being inflammation the focus of our effort, serum protein profiles were analyzed in order to investigate if this parameter could interfere ...
BELLEI, Elisa, BERGAMINI, Stefania, BIANCHI, Giampaolo, CUOGHI, Aurora, Francesco Borelli, MONARI, Emanuela, REGGIANI BONETTI, Luca, SIGHINOLFI, Maria Chiara, T. Ozben, TOMASI, Aldo   +9 more
core   +1 more source

The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes [PDF]

, 2021
H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes ...
Dahlström, Emma H., Flyvbjerg, Allan, Forsblom, Carol, Groop, Per-Henrik, Harjutsalo, Valma, Jansson Sigfrids, Fanny, Krarup Hansen, Troels, Ostergaard, Jakob Appel, Thiel, Steffen, Thorn, Lena M.   +9 more
core   +1 more source

Alveolar recruitment of ficolin-3 in response to acute pulmonary inflammation in humans

Immunobiology, 2016
Ficolins serve as soluble recognition molecules in the lectin pathway of complement. They are known to participate in the systemic host-response to infection but their role in local pulmonary defence is still incompletely understood. The purpose of this study was to clarify whether acute lung and systemic inflammation induce recruitment of lectins in ...
Plovsing, Ronni R, Berg, Ronan M G, Munthe-Fog, Lea, Konge, Lars, Iversen, Martin, Møller, Kirsten, Garred, Peter   +6 more
openaire   +3 more sources

Landscape of Immune Remodeling and NAP1L1‐Driven Epithelial Reprogramming in Gastric Cancer Metastasis

Chronic Diseases and Translational Medicine, EarlyView.
High‐resolution single‐cell atlas of normal gastric tissue, primary gastric cancer, and metastatic lesions. (A) Schematic diagram of experimental design. (B) Bar plot for qualified cell numbers in each lesion. (C) Cells annotation by canon markers for all cells. (D) Bubble chart for canon marker genes for each cell subtype.
Min Sun, Yuanzhi Wang, Yuqing Zhang, Xiaojuan Wang   +3 more
wiley   +1 more source

Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD [PDF]

, 2017
BACKGROUND: In cystic fibrosis and bronchiectasis, genetic mannose binding lectin (MBL) deficiency is associated with increased exacerbations and earlier mortality; associations in COPD are less clear.
Adrian Hapca, Aguirre, Albert, Alison J Dicker, Andrew J Cassidy, Aydemir, Boixeda, Brusselle, Colin N A Palmer, Elizabeth Furrie, Gill Brady, Gisli G Einarsson, J Stuart Elborn, James D Chalmers, Mandal, Megan L Crichton, Roger Tavendale, Sara E Marshall, Stuart Schembri   +18 more
core   +2 more sources

Serum MASP-1 in complex with MBL activates endothelial cells. [PDF]

, 2014
The complement system plays an important role in the induction of inflammation. In this study we demonstrate that the initiation complexes of the lectin pathway, consisting of mannose-binding lectin (MBL) and associated serine proteases (MASPs) elicit ...
Ambrus, Balázs Major, Beinrohr, Dahl, Davis, Degn, Degn, Degn, Degn, Dobó, Dobó, Dobó, Endre Schwaner, Erika Kajdácsi, Gulla, Gál, Hansen, Heja, Heja, Hess, Jensenius, János Rigó, József Dobó, Kidmose, Kocsis, László Cervenak, Matsushita, Matsushita, Matsushita, Megyeri, Megyeri, Márton Megyeri, Møller-Kristensen, Oroszlán, Paréj, Paréj, Péter Gál, Péter K. Jani, Péter Závodszky, Ricklin, Saeed, Skjoedt, Steffen Thiel, Stover, Takahashi, Thiel, Thiel, Thiel, Thiel, Thiel, van der Pol   +50 more
core   +1 more source

Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors

Frontiers in Immunology, 2021
Thousands of leprosy patients not only suffer from physical deformities, but also either have or have had hepatitis B virus (HBV) coinfection. Polymorphisms of the complement system modulate susceptibility to leprosy, but genetic susceptibility to past ...
Angelica Beate Winter Boldt, Angelica Beate Winter Boldt, Camila de Freitas Oliveira-Toré, Gabriela Canalli Kretzschmar, Hellen Weinschutz Mendes, Sérvio Túlio Stinghen, Fabiana Antunes Andrade, Valéria Bumiller-Bini, Letícia Boslooper Gonçalves, Anna Carolina de Moraes Braga, Ewalda von Rosen Seeling Stahlke, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Steffen Thiel, Iara José Taborda de Messias-Reason   +15 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

The Lectin Complement Pathway Is Involved in Protection Against Enteroaggregative Escherichia coli Infection

Frontiers in Immunology, 2018
Enteroaggregative Escherichia coli (EAEC) causes acute and persistent diarrhea worldwide. Still, the involvement of host factors in EAEC infections is unresolved. Binding of recognition molecules from the lectin pathway of complement to EAEC strains have
Camilla Adler Sørensen, Camilla Adler Sørensen, Anne Rosbjerg, Betina Hebbelstrup Jensen, Karen Angeliki Krogfelt, Peter Garred   +5 more
doaj   +1 more source