Results 111 to 120 of about 7,998 (276)

Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia

Advanced Science, Volume 12, Issue 10, March 13, 2025.
Immune thrombocytopenia (ITP) is an autoimmune disorder marked by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. It is found that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ...
Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Yingmei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shuya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yanxia Gao, Yong Jiang, Rongqun Guo   +21 more
wiley   +1 more source

Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism [PDF]

, 2017
Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced via limited proteolysis by another protease or by autoactivation.
Dani, Ráhel, Dobó, József, Gál, Péter, Oroszlán, Gábor, Szilágyi, András, Thiel, Steffen, Závodszky, Péter   +6 more
core   +2 more sources

Urinary Biomarkers Associated With Pathogenic Pathways Reflecting Histologic Findings in Lupus Nephritis

Arthritis &Rheumatology, Volume 77, Issue 3, Page 298-310, March 2025.
Objective There is a pressing need to understand the pathogenesis of histologic findings and identify the biomarkers for predicting the histologic severity in lupus nephritis (LN). This study aimed to identify the pathogenic signal pathway and elucidate urinary biomarkers for predicting the presence or severity of histologic findings in LN.
Kazuoto Hiramoto, Shuntaro Saito, Hironari Hanaoka, Jun Kikuchi, Hiroyuki Fukui, Akinori Hashiguchi, Katsuya Suzuki, Tsutomu Takeuchi, Yuko Kaneko   +8 more
wiley   +1 more source

Human ficolin‐2 recognition versatility extended: An update on the binding of ficolin‐2 to sulfated/phosphated carbohydrates [PDF]

FEBS Letters, 2014
Ficolin‐2 has been reported to bind to DNA and heparin, but the mechanism involved has not been thoroughly investigated. X‐ray studies of the ficolin‐2 fibrinogen‐like domain in complex with several new ligands now show that sulfate and phosphate groups are prone to bind to the S3 binding site of the protein.
Emilie Vassal-Stermann, Emmanuelle Laffly, Nicole M. Thielens, Christine Gaboriaud, Christine Gaboriaud, Monique Lacroix, Lydie Martin   +6 more
openaire   +4 more sources

Screening for immune-potentiating antigens from hepatocellular carcinoma patients after radiofrequency ablation by serum proteomic analysis

BMC Cancer, 2018
Background Radiofrequency ablation (RFA) can not only effectively kill hepatocellular carcinoma (HCC) tumour cells but also release tumour antigens that can provoke an immune response.
Shunli Shen, Hong Peng, Ye Wang, Ming Xu, Manxia Lin, Xiaoyan Xie, Baogang Peng, Ming Kuang   +7 more
doaj   +1 more source

The Significance of MAPK Signaling Pathway in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 1, March 2025.
We have developed a prognostic nomogram model that utilizes four genes (KRAS, JUN, RAP1B, and TNF) that are implicated in the hub MAPK signaling pathway to predict the prevalence of IDD patients. Additionally, we validated the expression levels of these genes in clinical samples.
Yong Liu, Xueyan Chen, Jingwen Chen, Chao Song, Zhangchao Wei, Zongchao Liu, Fei Liu   +6 more
wiley   +1 more source

Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies

MedComm, Volume 6, Issue 3, March 2025.
Ferroptosis, a cell death mode marked by iron accumulation and lipid peroxidation, plays a vital role in lung diseases and cancer. Its interaction with immune cells in the tumor microenvironment offers new therapeutic opportunities for lung cancer and pulmonary diseases .
Dandan Guo, Songhua Cai, Lvdan Deng, Wangting Xu, Sentao Fu, Yaling Lin, Tong Jiang, Qing Li, Zhijun Shen, Jian Zhang, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Ficolin-A Enhances Inhibition of the C-Terminal 19 kDa Re-gion of Merozoite Surface Protein-1 of Plasmodium berghei Using Test In Vivo

Iranian Journal of Parasitology, 2013
Background: Malaria remains a serious public health problem with significant morbidity and mortal­ity. This study was conducted to identify whether ficolin-A could play an active role of against mala­ria infection.Methods: The function of ficolin-A was ...
†F Chen, †Q Liu, Y Xue, YH Huang, FY Huang, Y Lin, GH Tan, J Zhou   +7 more
doaj   +2 more sources

Potential mechanisms implied in tick infection by arboviruses and their transmission to vertebrate hosts

Integrative Zoology, Volume 20, Issue 2, Page 315-330, March 2025.
We summarize the recent progress in understanding defense mechanisms in specific tissues or sites that are encountered by arboviruses and discuss their possible roles in virus infection or transmission. Abstract Ticks can transmit many pathogens, including arboviruses, to their vertebrate hosts.
Chuanfei YUAN, Qiong XU, Yunjia NING, Qianfeng XIA   +3 more
wiley   +1 more source

Plasma levels of H‐ and L‐ficolin are increased in axial spondyloarthritis: improvement of disease identification

Clinical and Experimental Immunology, 2020
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that primarily affects the axial skeleton. A predominance of innate versus adaptive immune responses have been reported in axSpA, indicating a prominent autoinflammatory component of the ...
A. Troldborg, S. Thiel, Clara Mistegaard Elbaek, A. Hansen, T. Korsholm, K. Stengaard-Pedersen, A. Loft   +6 more
semanticscholar   +1 more source