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Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen)
Molecular Immunology, 2008The ficolins and mannose-binding lectin (MBL) are collagen-like defence proteins that serve as recognition molecules in lectin complement pathway. Differential features that may indicate diverse functions of these proteins are poorly understood. In this study we compared important biological features of the ficolins and MBL.
Hummelshoj, Tina +4 more
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Histidine-regulated activity of M-ficolin
Biochemical Journal, 2008Human M-ficolin is a pathogen-associated molecular recognition molecule in the innate immune system, and it binds to some sugars, such as GlcNAc (N-acetylglucosamine), on pathogen surfaces. From previous structural and functional studies of the FD1 (M-ficolin fibrinogen-like domain), we proposed that the ligand-binding region of FD1 exists in a ...
Michikazu, Tanio, Toshiyuki, Kohno
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Molecular Cloning and Characterization of Mouse Ficolin-A
Biochemical and Biophysical Research Communications, 1998A novel ficolin-related gene was isolated from the mouse liver lambda ZAPII cDNA library. The protein encoded by this gene consists of both collagen- and fibrinogen-like domains, which are common features of the ficolin family, and was named mouse ficolin-A. The amino acid sequence of mouse ficolin-A is 60.2, 59.8, 59.8, and 59.6% identical to those of
Y, Fujimori +6 more
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2010
Ficolins constitute a family of proteins whose biological role has been an enigma for many years. Over the past few years it has become evident that ficolins are part of the innate immune system and function as recognition molecules in the complement system.
Garred, Peter +6 more
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Ficolins constitute a family of proteins whose biological role has been an enigma for many years. Over the past few years it has become evident that ficolins are part of the innate immune system and function as recognition molecules in the complement system.
Garred, Peter +6 more
openaire +1 more source
Ficolins: Structure, Function and Associated Diseases
2008Innate immunity relies upon the ability of a few pattern recognition molecules to sense molecular markers. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three ficolins have been identified in humans: L-ficolin, H-ficolin and M-ficolin (also referred to as ...
Xiao-Lian, Zhang, Mohammed A M, Ali
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Analysis of the Ligand Recognition Specificities of Human Ficolins Using Surface Plasmon Resonance
Methods in Molecular Biology, 2021Christine Gaboriaud +2 more
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