Results 171 to 180 of about 2,459 (190)

FICZ generates human tDCs that induce CD4+ CD25high Foxp3+ Treg-like cell differentiation

Immunology Letters, 2017
Dendritic cells (DCs) play a central role in the maintenance of immune homeostasis, their participation as professional antigen presenting cells is essential to the initiation of the adaptive immune response as well as to the induction of tolerance. The recently described role of the aryl hydrocarbon receptor (AhR) in the immune system, particularly in
Brenda B, Jurado-Manzano, Daniel, Zavala-Reyes, Edgar A, Turrubiartes-Martínez, Diana P, Portales-Pérez, Roberto, González-Amaro, Esther, Layseca-Espinosa   +5 more
openaire   +2 more sources

6-Formylindolo (3,2-b)Carbazole (FICZ) Enhances Retinoic Acid (RA)-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells [PDF]

Molecular Cancer, 2013
The aryl hydrocarbon receptor (AhR) ligand 6-Formylindolo(3,2-b)carbazole (FICZ) has received increasing attention since its identification as an endogenous AhR ligand and a photoproduct of tryptophan. FICZ and its metabolites have been detected in human fluids.
Rodica Bunaciu
exaly   +3 more sources

Selective cytochrome P450 1A1 but not 1B1 promoterCpG island DNA methylation by 6‐formylindolo[3,2‐b]carbazole (FICZ)

Journal of Biochemical and Molecular Toxicology, 2019
AbstractEpigenetic alterations are essential for normal mammalian development and regulation of gene expression. In this study, we aimed to determine if an enigmatic endogenous ligand of the aryl hydrocarbon receptor (AHR), 6‐formylindolo[3,2‐b]carbazole (FICZ), and methionine (Meth) have an epigenetic impact on AHR‐regulated cytochrome P450 1A1 and B1
Afsaneh Ghaedi, Majid Keshavarzi, Ali Ghafarian Bahraman, Afshin Mohammadi‐Bardbori   +3 more
openaire   +2 more sources

FICZ, a Tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma

International Immunopharmacology, 2012
Most studies about functions of aryl hydrocarbon receptor (AhR) in the pathogenesis of asthma have been carried out with non-physiological industrial by-products such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene. In the present study, effects of 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoproduct postulated as a candidate ...
Kyu-Tae, Jeong, Sung-Jun, Hwang, Gap-Soo, Oh, Joo-Hung, Park   +3 more
openaire   +2 more sources

Designing time-limited aryl hydrocarbon receptor drugs: A kinetic framework from the FICZ–CYP1A1 feedback axis

Drug Discovery Today
The aryl hydrocarbon receptor (AHR) has been historically excluded from drug development owing to the toxicity of canonical xenobiotic agonists. Drawing on the mechanistic logic of the 6-formylindolo[3,2-b]carbazole (FICZ)-cytochrome P450 1A1 (CYP1A1) axis, we propose a spatio-kinetic design framework built on three principles: optimizing ligand ...
Mahmoud Omidi, Amir Shadboorestan, Afshin Mohammadi-Bardbori   +2 more
openaire   +2 more sources

Targeting the aryl hydrocarbon receptor with FICZ regulates IL-2 and immune infiltration to alleviate Hashimoto's thyroiditis in mice

European Journal of Pharmacology
Hashimoto's thyroiditis (HT) is the most frequent autoimmune disorder. Growing work points to the involvement of aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, in the regulation of immune homeostasis. However, the roles of AhR and its ligands in HT remains unclear. In this study, we leveraged public human database analyses to
Zhengzheng Liao, Xianzhong Zeng, Xiaoling Guo, Qing Shi, Ziyun Tang, Ping Li, Cuiyun Chen, Mengxia Chen, Jianrong Chen, Jixiong Xu, Yaojun Cai   +10 more
openaire   +2 more sources

Biological effects of the proposed endogenous AHR ligand FICZ

Toxicology Letters, 2012
Agneta Rannug, E. Wincent, A. Mohammadi Bardbori, U. Rannug   +3 more
openaire   +1 more source

Ketoconazole activates the AHR by inhibiting CYP1A1 dependent metabolism of FICZ

Toxicology Letters, 2012
Johanna Bengtsson, Emma wincent, Agneta Rannug, Ulf Rannug   +3 more
openaire   +1 more source

Formation and background levels of the endogenous AHR ligand FICZ in vitro and in vivo

Toxicology Letters, 2012
Ulf Rannug, Anna Smirnova, Tomas Alsberg, Emma Wincent, Agneta Rannug   +4 more
openaire   +1 more source

Metals induce cytochrome P4501A1 through inhibition of metabolic degradation of FICZ

Toxicology Letters, 2012
Afshin Mohammadi Bardbori, Emma Wincent, Ulf Rannug, Agneta Rannug   +3 more
openaire   +1 more source