Results 1 to 10 of about 21,702 (299)

Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.

PLoS ONE, 2020
Skin aspartic acid protease (SASPase) is believed to be a key enzyme involved in filaggrin processing during epidermal terminal differentiation. Since little is known about the regulation of SASPase function, the aim of this study was to identify ...
Mark Donovan, Mélanie Salamito, Agnès Thomas-Collignon, Lucie Simonetti, Stephanie Desbouis, Jean-Christophe Rain, Etienne Formstecher, Dominique Bernard   +7 more
doaj   +6 more sources

Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion

Journal of Extracellular Vesicles, 2023
Filaggrin (FLG) protein is indispensable for multiple aspects of the epidermal barrier function but its accumulation in a monomeric filaggrin form may initiate premature keratinocytes death; it is unclear how filaggrin levels are controlled before the ...
Adrian Kobiela, Lilit Hovhannisyan, Paulina Jurkowska, Jorge Bernardino dela Serna, Aleksandra Bogucka, Milena Deptuła, Argho Aninda Paul, Kinga Panek, Ewa Czechowska, Michał Rychłowski, Aleksandra Królicka, Jacek Zieliński, Susanne Gabrielsson, Michał Pikuła, Magdalena Trzeciak, Graham S Ogg, Danuta Gutowska‐Owsiak   +16 more
doaj   +2 more sources

The Pathogenesis of Eosinophilic Asthma: A Positive Feedback Mechanism That Promotes Th2 Immune Response via Filaggrin Deficiency

Frontiers in Immunology, 2021
Eosinophilic asthma (EA) is a common subtype of asthma and often progresses to severe disease. In order to understand its pathogenesis, targeted next-generation gene sequencing was performed on 77 Chinese EA patients and 431 Chinese healthy controls to ...
Wei Gao, Jiuyu Gong, Mi Mu, Yujin Zhu, Yujin Zhu, Wenjuan Wang, Wen Chen, Guojing Han, Hong Hu, Pengtao Bao   +9 more
doaj   +2 more sources

The Discovery and Function of Filaggrin [PDF]

International Journal of Molecular Sciences, 2022
Keratohyalin granules were discovered in the mid-19th century in cells that terminally differentiate to form the outer, cornified layer of the epidermis.
J. Hoober, Laura L. Eggink
semanticscholar   +3 more sources

FilaggrinHigh melanomas exhibit active FGFR and allergic signatures with impaired GNA14 and Th1 signatures [PDF]

Frontiers in Genetics
Filaggrin gene (FLG/FLG2) product deregulations are associated with various allergic skin diseases, including but not limited to atopic dermatitis, alopecia areata, and ichthyosis vulgaris.
Goodwin G. Jinesh, Goodwin G. Jinesh, Isha Godwin   +2 more
doaj   +2 more sources

Revisiting the Roles of Filaggrin in Atopic Dermatitis

International Journal of Molecular Sciences, 2022
The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology research community and shed new light on a skin protein that was first ...
V. Moosbrugger-Martinz, C. Leprince, M. Méchin, M. Simon, S. Blunder, R. Gruber, S. Dubrac   +6 more
semanticscholar   +3 more sources

Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction [PDF]

Scientific Reports, 2016
We explored the regulation of filaggrin, cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) expression induced by urban particulate matter (PM) in human keratinocytes. In addition, we investigated the signaling pathways involved in PM-induced effects on
Chiang-Wen Lee, Zih-chan lin, Stephen Chu-Sung Hu, Y. Chiang, Lee-Fen Hsu, Yu-Ching Lin, I-Ta Lee, Ming-Horng Tsai, Jia-You Fang   +8 more
semanticscholar   +2 more sources

Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and immunoglobulin E

Clinical and Molecular Allergy, 2018
Background Allergic reactions have been implicated as contributions in a number of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and bronchial asthma (BA).
Zafar Rasheed, Khaled Zedan, Ghada Bin Saif, Ragaa H. Salama, Tarek Salem, Ahmed A. Ahmed, Alaa Abd El-Moniem, Maha Elkholy, Ahmad A. Al Robaee, Abdullateef A. Alzolibani   +9 more
doaj   +2 more sources

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents

Scientific Reports, 2017
Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology.
Leonie Wallmeyer, Kristina Dietert, Michaela Sochorová, Achim D. Gruber, Burkhard Kleuser, Kateřina Vávrová, Sarah Hedtrich   +6 more
doaj   +2 more sources

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response [PDF]

Brazilian Journal of Medical and Biological Research, 2015
The objective of this study was to investigate whether a single defect in skin barrier function simulated by filaggrin silencing could induce Th2-predominant inflammation.
N.N. Dang, S.G. Pang, H.Y. Song, L.G. An, X.L. Ma   +4 more
doaj   +3 more sources