Results 11 to 20 of about 21,422 (186)

Revisiting the Roles of Filaggrin in Atopic Dermatitis

International Journal of Molecular Sciences, 2022
The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology research community and shed new light on a skin protein that was first ...
V. Moosbrugger-Martinz, C. Leprince, M. Méchin, M. Simon, S. Blunder, R. Gruber, S. Dubrac   +6 more
semanticscholar   +1 more source

The Discovery and Function of Filaggrin

International Journal of Molecular Sciences, 2022
Keratohyalin granules were discovered in the mid-19th century in cells that terminally differentiate to form the outer, cornified layer of the epidermis.
J. Hoober, Laura L. Eggink
semanticscholar   +1 more source

FRA1:c-JUN:HDAC1 complex down-regulates filaggrin expression upon TNFα and IFNγ stimulation in keratinocytes

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Filaggrin (FLG) is one of the structural proteins for skin barrier function. Reduced FLG expression is implicated in the pathogenesis of inflammatory skin diseases, such as atopic dermatitis and psoriasis. However, it remains unclear how FLG
S. Ahn, Hyunjin Yeo, Euitaek Jung, Y. Lim, Young Han Lee, S. Shin   +5 more
semanticscholar   +1 more source

Analysis of filaggrin 2 gene polymorphisms in patients with atopic dermatitis, [PDF]

Anais Brasileiros de Dermatologia, 2020
Background: Polymorphisms of the filaggrin 2 gene (rs 12568784 and rs 16899374) are associated with persistent atopic dermatitis in African American patients. Filaggrin 2 is a protein with a function similar to filaggrin and also encoded in the epidermal
Amanda Hertz, Luna Azulay-Abulafia, Adriana Paulino do Nascimento, Cintya Yumi Ohara, Fabio Chigres Kuschnir, Luís Cristovão Porto   +5 more
doaj   +1 more source

IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis

Gut, 2022
Objective Disruption of the epithelial barrier plays an essential role in developing eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated food-associated and aeroallergen-associated chronic inflammation.
Tanay Kaymak, Berna Kaya, Philipp Wuggenig, Sandro Nuciforo, Andreas Göldi, F. Oswald, Julien Roux, M. Noti, H. Melhem, P. Hruz, J. Niess   +10 more
semanticscholar   +1 more source

Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

International Journal of Molecular Sciences, 2020
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 and IL-13 signatures.
M. Furue
semanticscholar   +1 more source

Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy *

British Journal of Dermatology, 2021
Loss‐of‐function mutations in the skin barrier gene filaggrin (FLG) increase the risk of atopic dermatitis (AD), but their role in skin barrier function, dry skin and eczema in infancy is unclear.
A. Hoyer, E. Rehbinder, M. Färdig, S. Asad, K. L. Lødrup Carlsen, K. M. Endre, B. Granum, G. Haugen, G. Hedlin, C. Monceyron Jonassen, S. Katayama, J. Konradsen, L. Landrø, M. LeBlanc, C. A. Mägi Olsson, K. Rudi, H. Skjerven, A. Staff, R. Vettukattil, M. Bradley, B. Nordlund, C. Söderhäll   +21 more
semanticscholar   +1 more source

Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family. [PDF]

PLoS ONE, 2009
Genes of the S100 fused-type protein (SFTP) family are clustered within the epidermal differentiation complex and encode essential components that maintain epithelial homeostasis and barrier functions.
Zhihong Wu, Britta Hansmann, Ulf Meyer-Hoffert, Regine Gläser, Jens-Michael Schröder   +4 more
doaj   +1 more source

Edible Bird’s Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte

Frontiers in Pharmacology, 2021
Edible bird’s nest (EBN) has been consumed as a Chinese delicacy for hundreds of years; the functions of which have been proposed to prevent lung disease, strengthen immune response, and restore skin youthfulness. To support the skin function of EBN, the
Queenie Wing Sze Lai, M. S. Guo, K. Q. Wu, Zhitao Liao, Dongshi Guan, T. Dong, P. Tong, K. Tsim   +7 more
semanticscholar   +1 more source

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. [PDF]

, 2020
BACKGROUND: Skin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children. METHODS: We did a multicentre, pragmatic, parallel-group, randomised controlled trial
BEEP study team, Boyle, RJ, Bradshaw, LE, Brown, SJ, Chalmers, JR, Cork, MJ, Davies-Jones, S, Flohr, C, Haines, RH, Jay, N, Kelleher, MM, Lawton, S, Mitchell, EJ, Montgomery, AA, Perkin, MR, Ridd, MJ, Sach, TH, Simpson, EL, Swinden, R, Tarr, S, Thomas, KS, Williams, HC   +21 more
core   +7 more sources