Results 11 to 20 of about 21,422 (186)
Revisiting the Roles of Filaggrin in Atopic Dermatitis
The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology research community and shed new light on a skin protein that was first ...
V. Moosbrugger-Martinz +6 more
semanticscholar +1 more source
The Discovery and Function of Filaggrin
Keratohyalin granules were discovered in the mid-19th century in cells that terminally differentiate to form the outer, cornified layer of the epidermis.
J. Hoober, Laura L. Eggink
semanticscholar +1 more source
Significance Filaggrin (FLG) is one of the structural proteins for skin barrier function. Reduced FLG expression is implicated in the pathogenesis of inflammatory skin diseases, such as atopic dermatitis and psoriasis. However, it remains unclear how FLG
S. Ahn +5 more
semanticscholar +1 more source
Analysis of filaggrin 2 gene polymorphisms in patients with atopic dermatitis, [PDF]
Background: Polymorphisms of the filaggrin 2 gene (rs 12568784 and rs 16899374) are associated with persistent atopic dermatitis in African American patients. Filaggrin 2 is a protein with a function similar to filaggrin and also encoded in the epidermal
Amanda Hertz +5 more
doaj +1 more source
Objective Disruption of the epithelial barrier plays an essential role in developing eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated food-associated and aeroallergen-associated chronic inflammation.
Tanay Kaymak +10 more
semanticscholar +1 more source
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 and IL-13 signatures.
M. Furue
semanticscholar +1 more source
Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy *
Loss‐of‐function mutations in the skin barrier gene filaggrin (FLG) increase the risk of atopic dermatitis (AD), but their role in skin barrier function, dry skin and eczema in infancy is unclear.
A. Hoyer +21 more
semanticscholar +1 more source
Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family. [PDF]
Genes of the S100 fused-type protein (SFTP) family are clustered within the epidermal differentiation complex and encode essential components that maintain epithelial homeostasis and barrier functions.
Zhihong Wu +4 more
doaj +1 more source
Edible bird’s nest (EBN) has been consumed as a Chinese delicacy for hundreds of years; the functions of which have been proposed to prevent lung disease, strengthen immune response, and restore skin youthfulness. To support the skin function of EBN, the
Queenie Wing Sze Lai +7 more
semanticscholar +1 more source
Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. [PDF]
BACKGROUND: Skin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children. METHODS: We did a multicentre, pragmatic, parallel-group, randomised controlled trial
BEEP study team +21 more
core +7 more sources

