Update on canine filaggrin: a review [PDF]
Veterinary Quarterly, 2020 Human filaggrin (FLG) plays a key role in epidermal barrier function, and loss-of-function mutations of its gene are primarily responsible for the development of human atopic dermatitis (AD).
D. Combarros, M. Cadiergues, M. Simon
semanticscholar +5 more sources
Filaggrin and atopic march [PDF]
Biochemia medica, 2019 There is an increasing number of experimental, genetic and clinical evidence of atopic dermatitis expression as a pre-condition for later development of other atopic diseases such as asthma, food allergy and allergic rhinitis.
I. Čepelak, S. Dodig, I. Pavić
semanticscholar +5 more sources
Orchestrated control of filaggrin–actin scaffolds underpins cornification [PDF]
Cell Death and Disease, 2018 Epidermal stratification critically depends on keratinocyte differentiation and programmed death by cornification, leading to formation of a protective skin barrier.
D. Gutowska-Owsiak +9 more
semanticscholar +8 more sources
Early‐life regional and temporal variation in filaggrin‐derived natural moisturizing factor, filaggrin‐processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis† [PDF]
British Journal of Dermatology, 2018 Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products [natural moisturizing factors (NMFs)], activities of
M. Mcaleer +10 more
semanticscholar +5 more sources
International Journal of Cosmetic Science, 2013 SynopsisProfilaggrin (proFLG) and its processing products are critical to the health and appearance of skin. The recent identification of loss‐of‐function filaggrin (FLG) mutations as a predisposing factor in ichthyosis vulgaris and atopic dermatitis has lead to a resurgent interest in this enigmatic protein.
Clive R. Harding +2 more
openalex +5 more sources
Loss-of-function Variants of the Filaggrin Gene are Associated with Atopic Eczema and Associated Phenotypes in Swedish Families [PDF]
, 2008 Elisabeth Ekelund +7 more
openalex +5 more sources
Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis [PDF]
Experimental & Molecular Medicine, 2005 Filaggrin is expressed in the cornified layer of epidermis and known to be one of the antigenic targets in rheumatoid arthritis. Although the citrulline residue in filaggrin is thought to be an antigenic determinant recognized by autoantibodies, the diagnostic sensitivity of synthetic citrullinated peptide is variable. To investigate the implication of
Kyungho Choi +12 more
openalex +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Filaggrin (FLG) is one of the structural proteins for skin barrier function. Reduced FLG expression is implicated in the pathogenesis of inflammatory skin diseases, such as atopic dermatitis and psoriasis. However, it remains unclear how FLG
S. Ahn +5 more
semanticscholar +1 more source
Analysis of filaggrin 2 gene polymorphisms in patients with atopic dermatitis, [PDF]
Anais Brasileiros de Dermatologia, 2020 Background: Polymorphisms of the filaggrin 2 gene (rs 12568784 and rs 16899374) are associated with persistent atopic dermatitis in African American patients. Filaggrin 2 is a protein with a function similar to filaggrin and also encoded in the epidermal
Amanda Hertz +5 more
doaj +1 more source
Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family. [PDF]
PLoS ONE, 2009 Genes of the S100 fused-type protein (SFTP) family are clustered within the epidermal differentiation complex and encode essential components that maintain epithelial homeostasis and barrier functions.
Zhihong Wu +4 more
doaj +1 more source