Results 11 to 20 of about 21,508 (266)

Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.

PLoS ONE, 2020
Skin aspartic acid protease (SASPase) is believed to be a key enzyme involved in filaggrin processing during epidermal terminal differentiation. Since little is known about the regulation of SASPase function, the aim of this study was to identify ...
Mark Donovan, Mélanie Salamito, Agnès Thomas-Collignon, Lucie Simonetti, Stephanie Desbouis, Jean-Christophe Rain, Etienne Formstecher, Dominique Bernard   +7 more
doaj   +5 more sources

Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion

Journal of Extracellular Vesicles, 2023
Filaggrin (FLG) protein is indispensable for multiple aspects of the epidermal barrier function but its accumulation in a monomeric filaggrin form may initiate premature keratinocytes death; it is unclear how filaggrin levels are controlled before the ...
Adrian Kobiela, Lilit Hovhannisyan, Paulina Jurkowska, Jorge Bernardino dela Serna, Aleksandra Bogucka, Milena Deptuła, Argho Aninda Paul, Kinga Panek, Ewa Czechowska, Michał Rychłowski, Aleksandra Królicka, Jacek Zieliński, Susanne Gabrielsson, Michał Pikuła, Magdalena Trzeciak, Graham S Ogg, Danuta Gutowska‐Owsiak   +16 more
doaj   +2 more sources

The Pathogenesis of Eosinophilic Asthma: A Positive Feedback Mechanism That Promotes Th2 Immune Response via Filaggrin Deficiency

Frontiers in Immunology, 2021
Eosinophilic asthma (EA) is a common subtype of asthma and often progresses to severe disease. In order to understand its pathogenesis, targeted next-generation gene sequencing was performed on 77 Chinese EA patients and 431 Chinese healthy controls to ...
Wei Gao, Jiuyu Gong, Mi Mu, Yujin Zhu, Yujin Zhu, Wenjuan Wang, Wen Chen, Guojing Han, Hong Hu, Pengtao Bao   +9 more
doaj   +2 more sources

Remodeling of the cell membrane-associated protein pool affects adhesive membrane properties in filaggrin insufficient keratinocytes and impacts distinct cellular and organellar functions [PDF]

BMC Biology
Background Atopic dermatitis (AD) is a highly prevalent inflammatory skin disease, affecting up to 30% of children at some point in their life and frequently persisting into adulthood.
Adrian Kobiela, Mikołaj Klimczuk, Paweł Kamil Serafin, Kamila Kitowska, Anna Biernacka, Reza Abouali, Jorge Bernardino de la Serna, Xinwen Wang, Felicja Gajdowska, Aniela Kosobucka, Aleksandra Małgorzata Siedlar, Amandine Hauer, Lilit Hovhannisyan, Aleksandra Bogucka, Jos P. H. Smits, Ellen H. van den Bogaard, Rafał Sądej, Graham S. Ogg, Danuta Gutowska-Owsiak   +18 more
doaj   +2 more sources

FilaggrinHigh melanomas exhibit active FGFR and allergic signatures with impaired GNA14 and Th1 signatures [PDF]

Frontiers in Genetics
Filaggrin gene (FLG/FLG2) product deregulations are associated with various allergic skin diseases, including but not limited to atopic dermatitis, alopecia areata, and ichthyosis vulgaris.
Goodwin G. Jinesh, Goodwin G. Jinesh, Isha Godwin   +2 more
doaj   +2 more sources

Update on canine filaggrin: a review [PDF]

Veterinary Quarterly, 2020
Human filaggrin (FLG) plays a key role in epidermal barrier function, and loss-of-function mutations of its gene are primarily responsible for the development of human atopic dermatitis (AD).
D. Combarros, M. Cadiergues, M. Simon
semanticscholar   +4 more sources

Orchestrated control of filaggrin-actin scaffolds underpins cornification. [PDF]

Cell Death and Disease, 2018
Epidermal stratification critically depends on keratinocyte differentiation and programmed death by cornification, leading to formation of a protective skin barrier.
Bernardino de la Serna, Jorge, Colin-York, Huw, Eggeling, Christian, Fritzsche, Marco, Gutowska-Owsiak, Danuta, Leeming, Michael, Naeem, Aishath, Ogg, Graham, O’Shaughnessy, Ryan, Podobas, Ewa Izabela   +9 more
core   +7 more sources

Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity:Implications for atopic dermatitis [PDF]

British Journal of Dermatology, 2018
Background: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products [natural moisturizing factors (NMFs ...
Barrett, Bartnikas, Breternitz, Brough, Brown, Carson, Chittock, Clements, Dapic, DeLapp, Fallon, Fluhr, Gibbs, Halkjaer, Hoath, Horimukai, Hsu, Irvine, Kamata, Kamata, Kashibuchi, Kelleher, Kennedy, Kuroda, Ludriksone, McAleer, Mohammed, Mohammed, Raj, Raj, Rawlings, Sandilands, Sandilands, Schwartz, Scott, Simpson, Stamatas, Stamatas, Strid, Strid, Tagami, Takahashi, Takeda, Takeda, Visscher, Voegeli, Voegeli, Weidinger, Yamamoto, Yamazaki   +49 more
core   +4 more sources

Filaggrin and atopic march [PDF]

Biochemia medica, 2019
There is an increasing number of experimental, genetic and clinical evidence of atopic dermatitis expression as a pre-condition for later development of other atopic diseases such as asthma, food allergy and allergic rhinitis.
I. Čepelak, S. Dodig, I. Pavić
semanticscholar   +6 more sources

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents

Scientific Reports, 2017
Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology.
Leonie Wallmeyer, Kristina Dietert, Michaela Sochorová, Achim D. Gruber, Burkhard Kleuser, Kateřina Vávrová, Sarah Hedtrich   +6 more
doaj   +2 more sources