Role of genetic aspect in pathogenesis of atopic dermatitis [PDF]
, 2013 The pathogenesis of atopic dermatitis (AD) is a very complicated process that involves an intricate array of molecules. Nowadays it is generally accepted that cytokines play an important role in the progression of the clinical presentation of atopic ...
Wesserling Martyna
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Recombinant Filaggrin Is Internalized and Processed to Correct Filaggrin Deficiency [PDF]
Journal of Investigative Dermatology, 2014 This study was designed to engineer a functional filaggrin (FLG) monomer linked to a cell-penetrating peptide (RMR) and to test the ability of this peptide to penetrate epidermal tissue as a therapeutic strategy for genetically determined atopic dermatitis (AD). A single repeat of the murine filaggrin gene (Flg) was covalently linked to a RMR motif and
Stout, Thomas E. +4 more
openaire +2 more sources
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. [PDF]
, 2015 Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth.
Adams +140 more
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A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis [PDF]
, 2016 BACKGROUND: Filaggrin, encoded by the FLG gene, is an important component of the skin’s barrier to the external environment and genetic defects in FLG strongly associate with Atopic Dermatitis (AD).
Brown, S +7 more
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Scientific Reports, 2022 Respiratory viral infections (RVIs) are frequent in preterm infants possibly inducing long-term impact on respiratory morbidity. Immune response and respiratory barriers are key defense elements against viral insults in premature infants admitted to ...
José M. Rodrigo-Muñoz +12 more
doaj +1 more source
Filaggrin Defect at Atopic Dermatitis: Modern Treatment Options
Вопросы современной педиатрии, 2022 Atopic dermatitis is a common chronic skin disease, its pathogenesis is associated with congenital or acquired deficiency of filaggrin protein. In recent years, extensive evidence on the causes of filaggrin deficiency has been obtained. The structure and
Nikolay N. Murashkin +8 more
doaj +1 more source
Orchestrated control of filaggrin-actin scaffolds underpins cornification. [PDF]
, 2018 Epidermal stratification critically depends on keratinocyte differentiation and programmed death by cornification, leading to formation of a protective skin barrier.
Bernardino de la Serna, Jorge +9 more
core +6 more sources
The Pathogenesis of Atopic Dermatitis: The Role of Filaggrin
Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2017 Background: Atopic dermatitis (AD) is a multifactorial skin disease with waxing and waning inflammatory process. In recent years, genetic mutations namely the null mutations of the filaggrin gene (FLG) has been the focus in AD risk factors investigations.
Tamarachiara Kuntjoro, Erna Harijati
doaj +1 more source
Frontiers in Pharmacology, 2022 Edible bird’s nest (EBN) is a Chinese delicacy possessing skin rejuvenating functions. To verify skin anti-inflammatory function of EBN, water extract and enzymatic digest of EBN, as well as the major sialic acid, N-acetyl neuraminic acid (NANA), were ...
Queenie Wing Sze Lai +10 more
doaj +1 more source
Comparative immune responses against Psoroptes ovis in two cattle breeds with different susceptibility to mange [PDF]
, 2015 The sheep scab mite, Psoroptes ovis, is a major problem in the beef cattle industry, especially in Belgian Blue (BB) cattle. This breed is naturally more predisposed to psoroptic mange but reasons for this high susceptibility remain unknown.
Chiers, Koen +9 more
core +4 more sources