Results 21 to 30 of about 21,508 (266)

Filaggrin and Beyond: New Insights into the Skin Barrier in Atopic Dermatitis and Allergic Diseases, From Genetics to Therapeutic Perspectives.

Annals of Allergy, Asthma & Immunology, 2023
N. Stefanovic, A. Irvine
semanticscholar   +2 more sources

Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants [PDF]

bioRxiv, 2017
The filaggrin gene (FLG) is essential for skin differentiation and epidermal barrier formation. FLG loss-of-function (LoF) variants are associated with ichthyosis vulgaris and the major genetic risk factor for developing atopic dermatitis (AD).1, 2, 3 ...
Aileen Sandilands, Angeline Su Ling Tay, Brown, Chen, Clark, E. Birgitte Lane, Frances J.D. Smith, Huijia Chen, Irvine, Jia Nee Foo, Jianjun Liu, John E.A. Common, Mark B.Y. Tang, Palmer, Rebecca L. Haines, Sandilands, Simon L.I.J. Denil, Smith, van den Oord, W.H. Irwin McLean, X.F. Colin C. Wong   +20 more
core   +4 more sources

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response [PDF]

Brazilian Journal of Medical and Biological Research, 2014
The objective of this study was to investigate whether a single defect in skin barrier function simulated by filaggrin silencing could induce Th2-predominant inflammation.
N.N. Dang, S.G. Pang, H.Y. Song, L.G. An, X.L. Ma   +4 more
doaj   +3 more sources

Filaggrin – revisited [PDF]

International Journal of Cosmetic Science, 2013
SynopsisProfilaggrin (proFLG) and its processing products are critical to the health and appearance of skin. The recent identification of loss‐of‐function filaggrin (FLG) mutations as a predisposing factor in ichthyosis vulgaris and atopic dermatitis has lead to a resurgent interest in this enigmatic protein.
C R, Harding, S, Aho, C A, Bosko
openaire   +2 more sources

One Remarkable Molecule: Filaggrin [PDF]

Journal of Investigative Dermatology, 2012
The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the cause of ichthyosis vulgaris-the most common disorder of keratinization-and also a strong genetic risk factor for atopic eczema, marked a significant breakthrough in the understanding of eczema pathogenesis.
Brown, Sara J., McLean, W. H. Irwin
openaire   +3 more sources

Cutaneous Deficiency of Filaggrin and STAT3 Exacerbates Vaccinia Disease In Vivo. [PDF]

PLoS ONE, 2017
Defects in filaggrin and STAT3 are associated with atopic dermatitis (AD) and susceptibility to severe skin infection.We evaluated skin infection with the current smallpox vaccine, ACAM-2000, in immunosuppressed mice with combined cutaneous deficiency in
Yong He, Ishrat Sultana, Kazuyo Takeda, Jennifer L Reed   +3 more
doaj   +1 more source

Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: A pivotal interplay in the pathogenesis of Atopic Dermatitis [PDF]

, 2018
Individuals with Atopic dermatitis (AD) are highly susceptible to Staphylococcus aureus colonization. However, the mechanisms driving this process as well as the impact of S. aureus in AD pathogenesis are still incompletely understood.
A Matlow, A Oliveira de, A Sandilands, A Sonesson, AC Krakowski, AD Irvine, AM Bowcock, B Cabanillas, B Han, BC Friedman, C Fux, C Pascolini, CI Ewing, CL Jinnestal, D Ellinghaus, D Lebeaux, DY Koller, DYM Leung, DYM Leung, E Clark, E Weinberg, EC Clark, EG Domenico Di, EG Domenico Di, FJ Bath-Hextall, FR Menegotto, G Stinco, GF Gad, GL Hazelbauer, GM O’Regan, GM O’Regan, GU Meduri, H Akiyama, HB Allen, HH Kong, I Marenholz, I Nomura, J Oh, J Schmitt, JH Lee, JM Hanifin, JQ Gong, K Becker, K Breuer, K Krause, KL Hon, L Chronopoulou, L Paternoster, LA O’Neill, LP Girard, M Bhattacharya, M Denis, M Mehrotra, M Niebuhr, MD Howell, ML Schuttelaar, MS Haque, P Castaneda, P Chavant, PH Hoeger, R Lever, R Saginur, RA McLaughlin, RL Gallo, RM Klevens, RP Howlin, S Eriksson, S Kanangat, S Kezic, S Kezic, S Stutte, S Weidinger, SE Hill, SE Satorres, SE Satorres, SH Cho, SH Hung, SJ Gilani, SX Xu, T Bieber, T Biedermann, T Kobayashi, T Nakatsuji, T Werfel, TX Nhan, UG Meduri, V Dossow von, W Abramovits, Z Ikezawa   +88 more
core   +1 more source

Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract

Veterinary Sciences, 2022
Filaggrin is an epidermal protein involved in skin barrier formation and hydration, whose expression is altered in canine atopic dermatitis (CAD). CAD patients also present an abnormal immune response with an altered expression of antimicrobial peptides (
Sergi Segarra, Tanesha Naiken, Julien Garnier, Valérie Hamon, Nathalie Coussay, François-Xavier Bernard   +5 more
doaj   +1 more source

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development [PDF]

, 2009
Acquisition of epidermal barrier function occurs late in mouse gestation. Several days before birth a wave of barrier acquisition sweeps across murine fetal skin, converging on dorsal and ventral midlines.
Byrne, C, O'Shaughnessy, RFL, Sully, K, Welti, JC   +3 more
core   +2 more sources

Fos co-operation with PTEN loss elicits keratoacanthoma not carcinoma due to p53/p21^WAF-induced differentiation triggered by GSK3b inactivation and reduced AKT activity [PDF]

, 2008
To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate PTEN function [K14.cre/D5PTENflx] in mouse epidermis expressing activated v-fos [HK1.fos].
Alexander, C.L., Chan, W-C., Greenhalgh, D.A., Quinn, J., Wu, H., Yao, D.   +5 more
core   +1 more source