Results 21 to 30 of about 21,702 (299)

IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis

Gut, 2022
Objective Disruption of the epithelial barrier plays an essential role in developing eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated food-associated and aeroallergen-associated chronic inflammation.
Tanay Kaymak, Berna Kaya, Philipp Wuggenig, Sandro Nuciforo, Andreas Göldi, F. Oswald, Julien Roux, M. Noti, H. Melhem, P. Hruz, J. Niess   +10 more
semanticscholar   +1 more source

Recombinant Filaggrin Is Internalized and Processed to Correct Filaggrin Deficiency [PDF]

Journal of Investigative Dermatology, 2014
This study was designed to engineer a functional filaggrin (FLG) monomer linked to a cell-penetrating peptide (RMR) and to test the ability of this peptide to penetrate epidermal tissue as a therapeutic strategy for genetically determined atopic dermatitis (AD). A single repeat of the murine filaggrin gene (Flg) was covalently linked to a RMR motif and
Binoy Appukuttan, Trevor J. McFarland, John C. Mitchell, Thomas E. Stout, J. Timothy Stout   +4 more
openaire   +2 more sources

Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy *

British Journal of Dermatology, 2021
Loss‐of‐function mutations in the skin barrier gene filaggrin (FLG) increase the risk of atopic dermatitis (AD), but their role in skin barrier function, dry skin and eczema in infancy is unclear.
A. Hoyer, E. Rehbinder, M. Färdig, S. Asad, K. L. Lødrup Carlsen, K. M. Endre, B. Granum, G. Haugen, G. Hedlin, C. Monceyron Jonassen, S. Katayama, J. Konradsen, L. Landrø, M. LeBlanc, C. A. Mägi Olsson, K. Rudi, H. Skjerven, A. Staff, R. Vettukattil, M. Bradley, B. Nordlund, C. Söderhäll   +21 more
semanticscholar   +1 more source

Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

International Journal of Molecular Sciences, 2020
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 and IL-13 signatures.
M. Furue
semanticscholar   +1 more source

Edible Bird’s Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte

Frontiers in Pharmacology, 2021
Edible bird’s nest (EBN) has been consumed as a Chinese delicacy for hundreds of years; the functions of which have been proposed to prevent lung disease, strengthen immune response, and restore skin youthfulness. To support the skin function of EBN, the
Queenie Wing Sze Lai, M. S. Guo, K. Q. Wu, Zhitao Liao, Dongshi Guan, T. Dong, P. Tong, K. Tsim   +7 more
semanticscholar   +1 more source

Evaluation of filaggrin 2 expression in dogs with atopic dermatitis before and after oclacitinib maleate administration. [PDF]

Vet Dermatol
Background – Canine atopic dermatitis (cAD) is a chronic, inflammatory, multifactorial and pruritic disease. The presence of skin barrier impairment (e.g. filaggrin alterations), along with abnormal immune responses, can negatively impact cutaneous barrier function.
Villalobos WR, Ferreira T, Borek F, Santoro D, Ferrer L, Farias M.   +5 more
europepmc   +2 more sources

Cutaneous Deficiency of Filaggrin and STAT3 Exacerbates Vaccinia Disease In Vivo. [PDF]

PLoS ONE, 2017
Defects in filaggrin and STAT3 are associated with atopic dermatitis (AD) and susceptibility to severe skin infection.We evaluated skin infection with the current smallpox vaccine, ACAM-2000, in immunosuppressed mice with combined cutaneous deficiency in
Yong He, Ishrat Sultana, Kazuyo Takeda, Jennifer L Reed   +3 more
doaj   +1 more source

Natural moisturizing factor as a biomarker for filaggrin mutation status in a multi‐ethnic paediatric atopic dermatitis cohort

Clinical and Experimental Allergy, 2021
Atopic dermatitis (AD) is a common inflammatory skin disease among children with increasing prevalence in the past decades. The strongest and most widely replicated genetic risk factor for AD is a null mutation in the filaggrin gene (FLG) located on ...
Minke M. F. Mierlo, P. Caspers, Marieke S. Jansen, G. Puppels, A. Nouwen, M. Bronner, L. Pardo, M. Geel, S. Pasmans   +8 more
semanticscholar   +1 more source

Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract

Veterinary Sciences, 2022
Filaggrin is an epidermal protein involved in skin barrier formation and hydration, whose expression is altered in canine atopic dermatitis (CAD). CAD patients also present an abnormal immune response with an altered expression of antimicrobial peptides (
Sergi Segarra, Tanesha Naiken, Julien Garnier, Valérie Hamon, Nathalie Coussay, François-Xavier Bernard   +5 more
doaj   +1 more source

Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: A pivotal interplay in the pathogenesis of Atopic Dermatitis [PDF]

, 2018
Individuals with Atopic dermatitis (AD) are highly susceptible to Staphylococcus aureus colonization. However, the mechanisms driving this process as well as the impact of S. aureus in AD pathogenesis are still incompletely understood.
A Matlow, A Oliveira de, A Sandilands, A Sonesson, AC Krakowski, AD Irvine, AM Bowcock, B Cabanillas, B Han, BC Friedman, C Fux, C Pascolini, CI Ewing, CL Jinnestal, D Ellinghaus, D Lebeaux, DY Koller, DYM Leung, DYM Leung, E Clark, E Weinberg, EC Clark, EG Domenico Di, EG Domenico Di, FJ Bath-Hextall, FR Menegotto, G Stinco, GF Gad, GL Hazelbauer, GM O’Regan, GM O’Regan, GU Meduri, H Akiyama, HB Allen, HH Kong, I Marenholz, I Nomura, J Oh, J Schmitt, JH Lee, JM Hanifin, JQ Gong, K Becker, K Breuer, K Krause, KL Hon, L Chronopoulou, L Paternoster, LA O’Neill, LP Girard, M Bhattacharya, M Denis, M Mehrotra, M Niebuhr, MD Howell, ML Schuttelaar, MS Haque, P Castaneda, P Chavant, PH Hoeger, R Lever, R Saginur, RA McLaughlin, RL Gallo, RM Klevens, RP Howlin, S Eriksson, S Kanangat, S Kezic, S Kezic, S Stutte, S Weidinger, SE Hill, SE Satorres, SE Satorres, SH Cho, SH Hung, SJ Gilani, SX Xu, T Bieber, T Biedermann, T Kobayashi, T Nakatsuji, T Werfel, TX Nhan, UG Meduri, V Dossow von, W Abramovits, Z Ikezawa   +88 more
core   +1 more source