Results 41 to 50 of about 17,078 (216)

The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update

open access: yesFrontiers in Molecular Biosciences, 2023
Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disease with various clinical presentations and combinations of symptoms. The pathophysiology of AD is complex and multifactorial.
Tubanur Çetinarslan   +2 more
doaj   +1 more source

Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses:part II of a prospective cohort study [PDF]

open access: yes, 2013
BACKGROUND/OBJECTIVES: Environmental exposure and personal susceptibility both contribute to the development of hand eczema. In this study, we investigated the effect of loss-of-function mutations in the filaggrin gene (FLG), atopic dermatitis and wet ...
Bakker, Jan G.   +8 more
core   +2 more sources

Consensus on the Clinical Approach to Moderate-to-Severe Atopic Dermatitis in Spain: A Delphi Survey [PDF]

open access: yes, 2020
Background. The purpose of this study was to gather information on the current assessment and management of patients with moderate-to-severe AD in routine daily practice. Methods.
Armario Hita, José Carlos   +9 more
core   +3 more sources

Functional Significance of Single-Nucleotide Polymorphism (rs11204981) in Filaggrin (flg) Gene for the Treatment of Bronchial Asthma in Children with Atopic Dermatitis

open access: yesZdorovʹe Rebenka, 2015
Objective. The objective of this study was to determine the correlation between single-nucleotide polymorphism in filaggrin gene and expression of filaggrin mRNA in buccal epithelium and the phenotype of bronchial asthma with atopic dermatitis in medical
O.P. Volosovets   +5 more
doaj   +1 more source

Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences

open access: yesFrontiers in Molecular Biosciences, 2022
Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel.
Ewa Izabela Podobas   +14 more
doaj   +1 more source

Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis [PDF]

open access: yesExperimental & Molecular Medicine, 2005
Filaggrin is expressed in the cornified layer of epidermis and known to be one of the antigenic targets in rheumatoid arthritis. Although the citrulline residue in filaggrin is thought to be an antigenic determinant recognized by autoantibodies, the diagnostic sensitivity of synthetic citrullinated peptide is variable. To investigate the implication of
Kyung Ho, Choi   +12 more
openaire   +2 more sources

Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort.

open access: yesPLoS ONE, 2009
BackgroundFilaggrin is a major protein in the epidermis. Several mutations in the filaggrin gene (FLG) have been associated with a number of conditions.
Santiago Rodriguez   +8 more
doaj   +1 more source

The Suppressive Effect of Leucine-Rich Glioma Inactivated 3 (LGI3) Peptide on Impaired Skin Barrier Function in a Murine Model Atopic Dermatitis

open access: yesPharmaceutics, 2020
This study aimed to restore the skin barrier function from atopic dermatitis (AD) via treatment with leucine-rich glioma inactivated 3 (LGI3) peptide. Male NC/Nga mice (7 weeks, 20 g) were randomly allocated into three groups (control, AD, and LGI3 group)
Ui Seok Kim   +8 more
doaj   +1 more source

Dupilumab Significantly Reduces Symptoms of Prurigo Nodularis and Depression: A Case Series

open access: yesActa Dermato-Venereologica, 2022
is missing (Short communication)
Louise Lönndahl   +3 more
doaj   +1 more source

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. [PDF]

open access: yes, 2019
Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the ...
Barton, Gregory M   +11 more
core   +1 more source

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