Results 61 to 70 of about 21,508 (266)

Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis [PDF]

Experimental & Molecular Medicine, 2005
Filaggrin is expressed in the cornified layer of epidermis and known to be one of the antigenic targets in rheumatoid arthritis. Although the citrulline residue in filaggrin is thought to be an antigenic determinant recognized by autoantibodies, the diagnostic sensitivity of synthetic citrullinated peptide is variable. To investigate the implication of
Kyung Ho, Choi, Eun Bong, Lee, Chang Dal, Yoo, Han Joo, Baek, Seong Wook, Kang, Ki Chul, Shin, Yun Jong, Lee, Hyun Ah, Kim, Ju Hong, Jeon, Chai Wan, Kim, Dong Myung, Shin, In Gyu, Kim, Yeong Wook, Son   +12 more
openaire   +2 more sources

Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased transcriptional-translational activity, keratinocyte-immune crosstalk and disordered axon guidance [PDF]

, 2019
Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin ( FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency ...
A Fabregat, A Naeem, A Sandilands, A Sandilands, B Kim, C Cole, C Cole, C Finan, C Flohr, C Hausmann, C He, C Lefèvre, C Palmer, C von Mering, D Szklarczyk, D Tobin, E Hoste, E Leclerc, E Rodriguez, E van den Bogaard, E van den Bogaard, F Smith, G Denecker, G McIlroy, H Alexander, H Baurecht, H Han, H Niehues, J Bergboer, J Folch, J Silverberg, J Timmerman, K Vávrová, L Paternoster, M Elias, M Elias, M Ferreira, M Kamsteeg, M Kretz, M Visser, N Novak, P Arkwright, P Di Meglio, P Gao, R Gruber, R Gruber, R Mateu, S Brown, S Brown, S Brown, S Brown, S Brown, S Brown, S Brown, S Brown, S Brown, S Johansson, S Smith, S Weidinger, T Elango, T Gil, T Matsui, V Rothhammer, V van Drongelen, W Damsky, Y Dou, Y Lee, Y Perez-Riverol, Z Xie, Z Zhu   +69 more
core   +2 more sources

Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort.

PLoS ONE, 2009
BackgroundFilaggrin is a major protein in the epidermis. Several mutations in the filaggrin gene (FLG) have been associated with a number of conditions.
Santiago Rodriguez, Amanda J Hall, Raquel Granell, W H Irwin McLean, Alan D Irvine, Colin N A Palmer, George Davey Smith, John Henderson, Ian N M Day   +8 more
doaj   +1 more source

The Suppressive Effect of Leucine-Rich Glioma Inactivated 3 (LGI3) Peptide on Impaired Skin Barrier Function in a Murine Model Atopic Dermatitis

Pharmaceutics, 2020
This study aimed to restore the skin barrier function from atopic dermatitis (AD) via treatment with leucine-rich glioma inactivated 3 (LGI3) peptide. Male NC/Nga mice (7 weeks, 20 g) were randomly allocated into three groups (control, AD, and LGI3 group)
Ui Seok Kim, Jin Woo Park, Eon Sub Park, Joon Seok Bang, Tae Woo Jung, Dong-Seok Kim, A. M. Abd El-Aty, Jong Hyuk Lee, Ji Hoon Jeong   +8 more
doaj   +1 more source

Dupilumab Significantly Reduces Symptoms of Prurigo Nodularis and Depression: A Case Series

Acta Dermato-Venereologica, 2022
is missing (Short communication)
Louise Lönndahl, Maria Lundqvist, Maria Bradley, Emma K. Johansson   +3 more
doaj   +1 more source

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. [PDF]

, 2019
Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the ...
Barton, Gregory M, Bautista, Diana M, Brem, Rachel B, Brock, Emily C, Deguine, Jacques, Gronert, Karsten, Hill, Rose Z, Kucirek, Natalie, Rifi, Ziad, Schwendinger-Schreck, Jamie, Walsh, Carolyn M, Wei, Jessica   +11 more
core   +1 more source

Fleshing Out Filaggrin Phenotypes [PDF]

Journal of Investigative Dermatology, 2007
The association of filaggrin null alleles with eczema has been replicated in several European populations. Three large, well-conducted studies confirm this association and offer insights into the phenotypic nature of eczema associated with these alleles.
openaire   +2 more sources

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Inactivation of mitogen-activated protein kinase signaling pathway reduces caspase-14 expression in impaired keratinocytes [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s):Several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. However, the precise regulation mechanism is still not clear.
Ningning Dang, Shuguang Pang, Haiyan Song, Liguo An, Xiaoli Ma   +4 more
doaj  

Association of Filaggrin Loss-of-Function Variants With Race in Children With Atopic Dermatitis.

JAMA dermatology, 2019
Importance Atopic dermatitis (AD) is a common chronic illness that has been associated with variation in the filaggrin gene (FLG). Four variants are most often evaluated.
D. Margolis, N. Mitra, B. Wubbenhorst, K. D’Andrea, A. Kraya, O. Hoffstad, Saloni Shah, K. Nathanson   +7 more
semanticscholar   +1 more source