Results 111 to 120 of about 6,491,911 (254)

The novel house dust mite allergen Der p 39 exacerbates atopic dermatitis-like inflammation in mice by inducing skin barrier dysfunction

World Allergy Organization Journal
Background: House dust mite (HDM) allergens can induce or exacerbate allergic inflammation, including atopic dermatitis (AD). Substances that damage the epithelial barrier can trigger or worsen AD.
Shan Liu, BSc, Ze-Lang Cai, MS, Jingcheng Liu, Si-Yi Que, BSc, Wan-Zhen Hu, MS, Liang Chen, MS, Jia-Jie Chen, PhD, Kunmei Ji, PhD   +7 more
doaj   +1 more source

Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway

International Journal of Molecular Sciences, 2017
The Japanese mugwort, Artemisia princeps (yomogi in Japanese), has anti-inflammatory and antioxidant effects. Skin care products containing Artemisia princeps extract (APE) are known to improve dry skin symptoms in atopic dermatitis.
Akiko Hirano, Masashi Goto, Tsukasa Mitsui, A. Hashimoto-Hachiya, G. Tsuji, M. Furue   +5 more
semanticscholar   +1 more source

Epidermal Differentiation Complex Yields a Secret: Mutations in the Cornification Protein Filaggrin Underlie Ichthyosis Vulgaris [PDF]

Journal of Investigative Dermatology, 2006
Ichthyosis vulgaris (IV), characterized by mild scaling on limbs and lower abdomen, has an incidence of 1 in 250. Smith, McLean, and colleagues demonstrate that common mutations in filaggrin underlie IV. Filaggrin aggregates keratin intermediate filaments and is cross-linked into the cornified envelope to form the epidermal barrier.
openaire   +2 more sources

The State of Prevention of Atopic Dermatitis: An Updated Review

Pediatric Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disorder that has a high worldwide prevalence and carries substantial psychosocial and financial burden. As such, the prevention of AD is an important area of research. In this review, we provide an update synthesizing relevant clinical trials published from January 2020 through July 2025 ...
Alexandra Kiszluk, Peter Lio
wiley   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk. [PDF]

, 2016
We have identified eight genes whose expression in human melanoma metastases and ovarian cancers is associated with a lack of Th1 immune signatures. They encode molecules with mechanical barrier function in the skin and other normal tissues and include ...
Bedognetti, D, Coukos, G, Deacon, Dh, Gajewski, Tf, Jr,, Marincola, Fm, Mauldin, Is, Obeid, Jm, Pinczewski, J, Salerno, Ep, Shea, Sm, Slingluff, Cl, Wang, E   +12 more
core   +2 more sources

Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin.

The Journal of biological chemistry, 1996
Peptidylarginine deiminases, which are commonly found in mammalian cells, catalyze the deimination of protein-bound arginine residues to citrullines. However, very little is known about their substrate requirements and the significance or consequences of this postsynthetic modification.
Edit Tarcsa, Giampiero Mei, Gerry Melino, Lyuben N. Marekov, Seung-Chul Lee, Peter M. Steinert   +5 more
openaire   +3 more sources

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

Comparative genomics of monotremes provides insights into the early evolution of mammalian epidermal differentiation genes

Scientific Reports
The function of the skin as a barrier against the environment depends on the differentiation of epidermal keratinocytes into highly resilient corneocytes that form the outermost skin layer.
Julia Steinbinder, Attila Placido Sachslehner, Karin Brigit Holthaus, Leopold Eckhart   +3 more
doaj   +1 more source

Detection of Diagnostic Antibodies in Immune‐Mediated Diseases: A Focus on Antigens and Technologies

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review explores autoantibody detection in immune‐mediated diseases, highlighting autoantigens including post‐translational modifications. We compared enzyme‐linked immunosorbent assay and indirect immunofluorescence with automated chemiluminescence platforms.
Silvia Bracci, Feliciana Real‐Fernandez, Federico Pratesi, Francesca Nuti, Paolo Rovero, Anna Maria Papini   +5 more
wiley   +1 more source