Results 91 to 100 of about 3,500 (185)

Role of Janus kinase Inhibitors (JAKis) in Autoimmune Disorders: Review [PDF]

JAK inhibitors (JAKis) comprise a crucial therapeutic tool for managing patients with immune-mediated inflammatory disorders. Although often perceived as a uniform class of medications thought to be largely interchangeable, notable variances exist in ...
H. Shehata, Lamia, M. Nasr, Mohamed, Naser, Maged   +2 more
core   +2 more sources

Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications [PDF]

, 2022
OBJECTIVES: DISH has been associated with increased coronary artery calcifications and incident ischaemic stroke. The formation of bone along the spine may share pathways with calcium deposition in the aorta.
Asselbergs, FW, Bots, ML, De Borst, GJ, De Jong, PA, De Jong, PA, Emmelot, MH, Foppen, W, Geerlings, MI, Harlianto, NI, Hol, ME, Kappelle, LJ, Leiner, T, Lely, AT, Mohamed Hoesein, FAA, Nathoe, HM, Ruigrok, YM, Van Der Kaaij, NP, Van Der Veen, PH, Van Ginneken, B, Verhaar, MC, Verlaan, JJ, Visseren, FLJ, Westerink, J, Wittenberg, R   +23 more
core  

Gastrointestinal Perforation as a Safety Concern Among Patients With Rheumatoid Arthritis Receiving JAK Inhibitor Therapy: A Systematic Review and Network Meta‐Analysis

Arthritis Care &Research, Volume 77, Issue 10, Page 1222-1228, October 2025.
Objective Gastrointestinal perforation (GIP) is a rare and life‐threatening safety concern associated with JAK inhibitors (JAKi). We aimed to review the evidence regarding the risk of GIP associated with the use of JAKi in patients with rheumatoid arthritis (RA) using a systematic review and network meta‐analysis approach.
Thipsukhon Sathapanasiri, Manuel Meraz, Hamraz Mokri, Sajesh K. Veettil, Karn Wijarnpreecha, Naomi Schlesinger, Arthur Kavanaugh, Nathorn Chaiyakunapruk   +7 more
wiley   +1 more source

Recommendations for the Use of Disease‐Modifying Antirheumatic Drugs in Pregnancy and Reproductive Health for Patients With Rheumatic Disease: A Scoping Review

Arthritis Care &Research, Volume 77, Issue 10, Page 1273-1281, October 2025.
Objective Autoimmune rheumatic diseases commonly affect individuals of childbearing age, with historically increased adverse pregnancy outcomes in this group. The advent of disease‐modifying antirheumatic drugs (DMARDs) has fostered more suitable conditions for pregnancy; however, this is accompanied by challenges in ensuring safe use in reproductive ...
Athena Chin, Alice Terrett, Mihye Kwon, Samuel Whittle, Catherine Hill   +4 more
wiley   +1 more source

Unveiling the Potential of JAK Inhibitors in Inflammatory Bowel Disease

Biologics
Background: Janus kinase (JAK) inhibitors represent a novel class of oral therapies showing efficacy in treating ulcerative colitis (UC) and Crohn’s disease (CD), challenging conventional treatment paradigms.
Shahed Kamal, Sheng Wei Lo, Samantha McCall, Beverly Rodrigues, Andrew H. Tsoi, Jonathan P. Segal   +5 more
doaj   +1 more source

Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis

Drugs in Context, 2019
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint involvement, extra-articular manifestations, comorbidities, and increased mortality.
Martina Biggioggero, Andrea Becciolini, Chiara Crotti, Elena Agape, Ennio Giulio Favalli   +4 more
doaj   +1 more source

Small Molecules in the Treatment of Acute Severe Ulcerative Colitis: A Review of Current Evidence

Pharmaceuticals
Ulcerative colitis (UC) is an inflammatory bowel disease in which one-quarter of patients are at risk of developing a severe form of the disease known as acute severe UC (ASUC).
Raffaele Pellegrino, Giuseppe Imperio, Ilaria De Costanzo, Michele Izzo, Fabio Landa, Assunta Tambaro, Antonietta Gerarda Gravina, Alessandro Federico   +7 more
doaj   +1 more source

Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE [PDF]

, 2022
OBJECTIVES: Juvenile-onset systemic lupus erythematosus (jSLE) affects 15–20% of lupus patients. Clinical heterogeneity between racial groups, age groups and individual patients suggests variable pathophysiology.
Beresford, M, Charras, A, Ciurtin, Coziana, Egbivwie, N, Haldenby, S, Hedrich, C, Olohan, L, Smith, Eve   +7 more
core  

Clear Cell Renal Carcinoma in an Ulcerative Colitis Patient Under Short-Term Immunosuppressive Therapy: A Case Report

Clinics and Practice
Background/Objectives: Renal cell cancer is a rare occurrence in patients with ulcerative colitis (UC), with no clearly demonstrated association between UC and an increased risk of renal malignancies.
Raffaele Pellegrino, Giuseppe Imperio, Michele Izzo, Ilaria De Costanzo, Fabio Landa, Paola Ciamarra, Marco Niosi, Antonietta Gerarda Gravina, Alessandro Federico   +8 more
doaj   +1 more source

Propensity score-matched real-world comparative treatment outcomes of Janus kinase inhibitors for ulcerative colitis in patients with and without prior exposure to anti-tumor necrosis factor α antibody [PDF]

Intestinal Research
Background/Aims Tofacitinib (TFB), filgotinib (FIL), and upadacitinib (UPA) are Janus kinase (JAK) inhibitors approved for moderate-to-severe ulcerative colitis (UC).
Maiko Ikenouchi, Hirokazu Fukui, Soichi Yagi, Akira Nogami, Koji Kaku, Toshiyuki Sato, Mikio Kawai, Koji Kamikozuru, Yoko Yokoyama, Tetsuya Takagawa, Toshihiko Tomita, Taku Kobayashi, Shinichiro Shinzaki   +12 more
doaj   +1 more source