Results 101 to 110 of about 3,500 (185)

Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease:DRIMID study protocol [PDF]

Introduction:Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) faces significant challenges, including small patient populations, complex clinical trial design and difficulties in patient recruitment.
Checa, Cesar Magro, Geertsema-Hoeve, Bettina C., Goekoop, Robbert J., Present, Erik, Raaphorst, Joost, Rekers, Nicolle H., Tas, Sander W., Thurlings, Rogier M., van Laar, Jacob M., van Laar, Jan A.M., Welsing, Paco M.J.   +10 more
core   +2 more sources

Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: results from a randomised, dose-finding study [PDF]

, 2016
Objectives: To evaluate the efficacy and safety of different doses and regimens of filgotinib, an oral JAK1 inhibitor, as add-on treatment to methotrexate (MTX) in patients with active rheumatoid arthritis (RA) and inadequate response to MTX. Methods: In
Alten, R, Enriquez-Sosa, F, Greenwald, M, Harrison, P, Mazur, M, Pavlova, D, Tasset, C, Taylor, Peter, Van der Aa, A, Vanhoutte, F, Westhovens, R   +10 more
core   +2 more sources

Novel Therapeutic Approaches in Rheumatoid Arthritis: Role of Janus Kinases Inhibitors.

, 2018
Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage and bone destruction and several systemic features.
Barbieri, L, de Paulis, A, Liccardo, B, Lobasso, A, Rivellese, F, Rossi, FW   +5 more
core   +2 more sources

Correction to: Filgotinib: First Approval [PDF]

Drugs, 2021
Dhillon, Sohita, Keam, Susan J.
openaire   +1 more source

[Cost per Responder Analysis of Filgotinib in Patients Suffering from Ulcerative Colitis] [PDF]

OBJECTIVE: To evaluate the costs and benefits associated with the use of biologics and Janus kinase inhibitors (JAKi) for the treatment of bio-experienced patients suffering from ulcerative colitis in Italy.METHODS: This pharmacoeconomic analysis ...
Castello, Luca, Povero, Massimiliano, Pradelli, Lorenzo, Visentin, Elena   +3 more
core   +3 more sources

Filgotinib bei Colitis ulcerosa: ein Review

Journal für Gastroenterologische und Hepatologische Erkrankungen
ZusammenfassungColitis ulcerosa ist eine chronisch entzündliche Darmerkrankung mit Befall des Kolons. Die häufigsten Symptome sind blutige und schleimige Durchfälle, Stuhldrang sowie abdominelle Schmerzen. Diese Symptome stellen für die Betroffenen oft eine wesentliche gesundheitliche Beeinträchtigung dar.Filgotinib ist ein Medikament, das in oraler ...
Blesl, Andreas, Novacek, Gottfried, Reinisch, Walter, Kienbauer, Melanie, Platzer, Reingard, Wolzt, Michael, Koch, Robert, Högenauer, Christoph, Ribarics, Reiner, Moschen, Alexander   +9 more
openaire   +2 more sources

Filgotinib in Active Noninfectious Uveitis: The HUMBOLDT Randomized Clinical Trial [PDF]

IMPORTANCE: Noninfectious uveitis is a leading cause of visual impairment with an unmet need for additional treatment options. OBJECTIVE: To assess the efficacy and safety of filgotinib, a Janus kinase 1 (JAK1) preferential inhibitor, for the treatment ...
Barchuk, William T, Besuyen, Robin, Chu, David S, Dacey, Mark S, Dick, Andrew D, Faia, Lisa J, Genovese, Mark C, Grewal, Dilraj S, Guo, Ying, Nguyen, Quan Dong, Rosenbaum, James T, Scales, David K, Shah, Rajiv E, Sharma, Sumit, Srivastava, Sunil K, Suhler, Eric B, Watkins, Timothy R   +16 more
core  

Assessing the construct validity of musculoskeletal ultrasound and the rheumatoid arthritis foot disease activity index (RADAI-F5) for managing rheumatoid foot disease [PDF]

, 2023
Dickson, Diane M., Hendry, Gordon J., Hoque, Anika, Steultjens, Martijn   +3 more
core   +1 more source

Experimental and Investigational Pharmacotherapy for Psoriatic Arthritis: Drugs of the Future

Journal of Experimental Pharmacology, 2020
Luca Navarini,1,* Damiano Currado,1,* Luisa Costa,2 Marco Tasso,2 Maria Sole Chimenti,3 Francesco Caso2 1Unit of Rheumatology, Immunology and Clinical Medicine, Università Campus Bio-Medico Di Roma, Rome, Italy; 2Rheumatology Unit, Department of ...
Navarini L, Currado D, Costa L, Tasso M, Chimenti MS, Caso F   +5 more
doaj  

Refractory Pyostomatitis Vegetans With Multiple Aseptic Cutaneous Abscesses Successfully Treated With Filgotinib in Ulcerative Colitis

JEADV Clinical Practice
We report on a 31‐year‐old male patient diagnosed with active moderate‐to‐severe ulcerative colitis and a history of splenectomy. He was hospitalized due to confluent pustular oral lesions and multiple skin abscesses.
C. Dandoy, D. Franchimont, C. Delvaux, A. Buggenhout, D. Bernardi, V. Del Marmol, J. M. L. White   +6 more
doaj   +1 more source