Results 111 to 120 of about 3,500 (185)

The efficacy and safety of different Janus kinase inhibitors as monotherapy in rheumatoid arthritis: A Bayesian network meta-analysis.

PLoS ONE
ObjectiveThis study aims to evaluate the efficacy and safety of JAK inhibitors in the treatment of patients with RA.MethodsThe databases CNKI, VIP, Wanfang, CBM, and PubMed, Embase, Cochrane Library and Web of Science were searched to identify relevant ...
Bingjia Qu, Feng Zhao, Ying Song, Junyi Zhao, Yuxin Yao, Yulan Chen, Ruobing Liao, Lingyu Fu   +7 more
doaj   +1 more source

Effectiveness and safety of filgotinib in rheumatoid arthritis: a real-life multicentre experience [PDF]

Objectives: We investigated the effectiveness and safety of filgotinib in a real-life multicentre cohort of rheumatoid arthritis (RA) patients. Methods: RA patients were evaluated at baseline and after 12 and 24 weeks and were stratified based on ...
Aprile, Maria Letizia, Atzeni, Fabiola, Bentivegna, Mario, Bursi, Roberto, Camarda, Federica, Cassarà, Emanuele, Colaci, Michele, Corrao, Salvatore, Dal Bosco, Ylenia, De Andres, Maria Ilenia, Debilio, Carmelo, Foti, Rosario, Franchina, Veronica, Giardina, Annarita, Guggino, Giuliana, La Barbera, Lidia, Lo Gullo, Alberto, Luppino, Flavia, Miceli, Giovanni, Molica Colella, Aldo Biagio, Provenzano, Giuseppe, Rizzo, Chiara   +21 more
core   +1 more source

Adapted treatment of ANCA-associated vasculitis during the COVID-19 pandemic [PDF]

, 2021
Nimmo, Ailish, Risdale, Saira
core   +2 more sources

The role of Janus kinase signaling in graft-versus-host disease and graft versus leukemia [PDF]

, 2018
Choi, Jaebok, DiPersio, John F, Schroeder, Mark A, Staser, Karl   +3 more
core   +2 more sources

Filgotinib [PDF]

, 2020
openaire   +1 more source

Exploring the interactions of JAK inhibitor and S1P receptor modulator drugs with the human gut microbiome: Implications for colonic drug delivery and inflammatory bowel disease [PDF]

The gut microbiota is a complex ecosystem, home to hundreds of bacterial species and a vast repository of enzymes capable of metabolising a wide range of pharmaceuticals.
Abdalla, Youssef, Basit, Abdul, Favaron, Alessia, Gaisford, Simon, McCoubrey, Laura E, Nandiraju, Laxmi Prasanna, Orlu, Mine, Shorthouse, David   +7 more
core  

Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition of nucleic acid synthesis, mRNA splicing, and protein stability

Virulence
Influenza A virus (IAV) poses a threat to patients receiving immunosuppressive medications since they are more susceptible to infection with severe symptoms, and even death.
Xin Wang, Feiyang Pu, Xuanye Yang, Xili Feng, Jiayou Zhang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiao-Xia Ma, Xiao-Ming Yang   +9 more
doaj   +1 more source

Filgotinib in cutaneous lupus: is a negative positive? [PDF]

Rheumatology, 2021
Kathryn Connelly, Eric F Morand
openaire   +2 more sources

Focus on Filgotinib in Rheumatoid Arthritis: A Trial-Based Review

Mediterranean Journal of Rheumatology
Janus kinases (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway is involved in pathophysiologic cascade of a notable number of rheumatic diseases. The development of JAK inhibitors has expanded treatment choices in rheumatoid arthritis (RA) with a sustained class-effect efficacy.
Skouvaklidou, Elpida, Deligeorgakis, Dimitrios, Skalkou, Anastasia, Skepastianos, Vasileios, Tsafis, Konstantinos, Papadimitriou, Evdokia, Pagkopoulou, Eleni, Avgerou, Paraskevi, Mytilinaiou, Maria G, Tzitiridou-Chatzopoulou, Maria, Kougkas, Nikolaos, Adamichou, Christina   +11 more
openaire   +2 more sources

Filgotinib in Crohn’s Disease: JAK Is Back [PDF]

Gastroenterology, 2017
Silvio, Danese, Gionata, Fiorino, Laurent, Peyrin-Biroulet   +2 more
openaire   +2 more sources