Results 51 to 60 of about 4,521 (193)

Efficacy and Safety of Small Molecule Inhibitor Therapies for Vitiligo: A Systematic Review

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims The latest advances in the treatment of vitiligo involve the introduction of Janus kinase inhibitors (JAKI) and small molecule inhibitors (SMI). These modern treatment modalities target specific inflammatory pathways that can improve outcomes for vitiligo in adults, adolescents, and children.
Alireza Jafarzadeh, Mohammad Amin Darvishi, Mina Khosravi, Masoumeh Roohaninasab, Azadeh Goodarzi   +4 more
wiley   +1 more source

Long-term safety and efficacy of filgotinib for the treatment of moderately to severely active ulcerative colitis: Interim analysis from up to 4 years of follow-up in the SELECTION open-label long-term extension study [PDF]

BACKGROUND Filgotinib, an oral, once-daily, Janus kinase 1 preferential inhibitor, is an approved treatment for moderately to severely active ulcerative colitis.
Beales, Ian, Danese, Silvio, de Haas, Angela, Faes, Margaux, Feagan, Brian G, Kim, Hyo Jong, Laharie, David, Loftus, Edward V, Masior, Tomasz, Matsuoka, Katsuyoshi, Peyrin-Biroulet, Laurent, Rogler, Gerhard, Rudolph, Christine, Schreiber, Stefan, Vermeire, Séverine   +14 more
core   +1 more source

Small Molecules, Big Results: How JAK Inhibitors Have Transformed the Treatment of Patients with IBD. [PDF]

Small molecule Janus kinase (JAK) inhibitors have revolutionized the management of ulcerative colitis (UC) and Crohns disease (CD) through their low immunogenicity, safety, and consistent pharmacologic response that are superior to existing therapeutic ...
Fansiwala, Kush, Sauk, Jenny
core   +1 more source

Cocaine-induced granulomatosis with polyangiitis—an under-recognized condition [PDF]

, 2023
Objectives: Cocaine and cocaine mixed with levamisole are increasingly used in the UK and result in significant direct nasal damage in addition to promoting vasculitis.
Burns, Aine, Chanouzas, Dimitrios, Gane, Simon, Gill, Charn, Hamour, Sally, Harper, Lorraine, Henderson, Scott R, Mcclelland, Lisha, Ozbek, Leyla, Pepper, Ruth J, Salama, Alan D, Sturman, Joseph   +11 more
core  

Bowel Urgency Improvement Correlates With Clinical, Biochemical, and Intestinal Ultrasound Improvements in Inflammatory Bowel Disease: A Cross Sectional Multicenter Study

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Bowel urgency (BU) is reported by over 80% of patients with ulcerative colitis (UC) and 60% of those with Crohn's disease (CD). However, the impact of advanced therapies on BU has not been consistently evaluated. Objectives To assess the effect of advanced therapies on BU improvement in patients with UC and CD.
Ferdinando D'Amico, Olga Maria Nardone, Alessandro Bruno, Mariangela Allocca, Alessandra Zilli, Federica Furfaro, Tommaso Lorenzo Parigi, Virginia Solitano, Federica Ungaro, Ilaria Faggiani, Alessia La Mantia, Giulio Calabrese, Gionata Fiorino, Vipul Jairath, Laurent Peyrin‐Biroulet, Luca Massimino, Fabiana Castiglione, Silvio Danese   +17 more
wiley   +1 more source

Preparation of colon-targeted pellets loaded with filgotinib/berberine hydrochloride and Their application in ulcerative colitis therapy. [PDF]

Int J Pharm X
Ulcerative colitis (UC) is a recurrent-remitting autoimmune disease of the colon, the pathogenesis of which remains incompletely understood. Recent studies have revealed gut dysbiosis and immune imbalance mediated by the JAK-STAT and NF-κB signaling ...
Wang J, Kuang Z, Chen B, Yan C, Shi B, Li G.   +5 more
europepmc   +2 more sources

Insights Into Late‐Onset Rheumatoid Arthritis (LORA): Characteristics (Clinical and Imaging), Comorbidities, and Therapeutic Targets

Geriatrics &Gerontology International, Volume 26, Issue 2, February 2026.
The main features of late‐onset rheumatoid arthritis (LORA), manifesting after age 65, are acute onset, higher disease activity, systemic involvement, and less presence of autoantibodies. Management requires individualized strategies, balancing aggressive treat‐to‐target therapy in robust patients with frailty‐focused approaches to prevent geriatric ...
Fausto Salaffi, Marina Carotti, Sonia Farah, Francesca Bandinelli, Luca Ceccarelli, Andrea Di Matteo, Marco Di Carlo   +6 more
wiley   +1 more source

JAK efficacy in Crohn’s disease [PDF]

, 2020
Inhibition of Janus kinases in Crohn’s disease (CD) patients has shown conflicting results in clinical trials. Tofacitinib, a pan-JAK inhibitor showed efficacy in ulcerative colitis (UC) and has been approved for the treatment of patients with moderate ...
Rogler, Gerhard
core   +1 more source

Refractory Pyostomatitis Vegetans With Multiple Aseptic Cutaneous Abscesses Successfully Treated With Filgotinib in Ulcerative Colitis

JEADV Clinical Practice
We report on a 31‐year‐old male patient diagnosed with active moderate‐to‐severe ulcerative colitis and a history of splenectomy. He was hospitalized due to confluent pustular oral lesions and multiple skin abscesses.
C. Dandoy, D. Franchimont, C. Delvaux, A. Buggenhout, D. Bernardi, V. Del Marmol, J. M. White   +6 more
semanticscholar   +1 more source

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source