Results 71 to 80 of about 3,500 (185)

Efficacy and safety of selective JAK 1 inhibitor filgotinib in active rheumatoid arthritis patients with inadequate response to methotrexate: comparative study with filgotinib and tocilizumab examined by clinical index as well as musculoskeletal ultrasound assessment (TRANSFORM study): study protocol for a randomized, open-label, parallel-group, multicenter, and non-inferiority clinical trial

Trials, 2023
Background Administration of Janus kinase (JAK) inhibitors and biological disease-modifying antirheumatic drugs has dramatically improved even the clinical outcomes in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate ...
Toshimasa Shimizu, Shin-ya Kawashiri, Shimpei Morimoto, Yurika Kawazoe, Shohei Kuroda, Rina Kawasaki, Yasuko Ito, Rieko Kiya, Shuntaro Sato, Hiroshi Yamamoto, Atsushi Kawakami   +10 more
doaj   +1 more source

JAK Inhibitors and Memory Impairment: Disproportionality Analyses in the WHO Global Pharmacovigilance Database, VigiBase

Fundamental &Clinical Pharmacology, Volume 40, Issue 1, January 2026.
ABSTRACT Background Chronic inflammation is involved in various mechanisms of memory impairment (MI). Although Janus kinase inhibitors (JAKi), which inhibit cytokine‐induced JAK–STAT pathway, could theoretically protect against MI, we faced an unexpected case of MI in a non‐elderly patient treated with JAKi.
Marilou Duboëlle, Adriano Lercara, Yves‐Marie Pers, Céline Michel, Marion Lepelley, Marie‐Blanche Valnet‐Rabier, Jean‐Luc Faillie, Virginie Bres, Pascale Palassin   +8 more
wiley   +1 more source

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

Small Molecules, Big Results: How JAK Inhibitors Have Transformed the Treatment of Patients with IBD. [PDF]

Small molecule Janus kinase (JAK) inhibitors have revolutionized the management of ulcerative colitis (UC) and Crohns disease (CD) through their low immunogenicity, safety, and consistent pharmacologic response that are superior to existing therapeutic ...
Fansiwala, Kush, Sauk, Jenny
core   +1 more source

International Survey of Gastroenterologists on Managing Inflammatory Bowel Disease During Pregnancy and Lactation: Current State and the Necessity for Improvements

United European Gastroenterology Journal, Volume 13, Issue 10, Page 1999-2011, December 2025.
ABSTRACT Background Reproduction is a fundamental aspect of life. This study aimed to provide an international overview of gastroenterologists' approaches to managing inflammatory bowel disease (IBD) during preconception, pregnancy, lactation, and postpartum. Methods An anonymous 75‐question survey was distributed to gastroenterologists in 36 countries,
María José Casanova, Javier P. Gisbert, Aurelien Amiot, Hannah Gordon, Gionata Fiorino, Emma Flanagan, Paulo Gustavo Kotze, Aleksandra Sokic‐Milutinovic, Elena Sonnenberg, Paulina Nuñez, Andreas Blesl, Ignacio Catalán‐Serra, Peter Bossuyt, Rafal Filip, Ariella Bar‐Gil Shitrit, Anna Kagramanova, Zeljko Krznaric, Paulina Molander, Gerassimos J. Mantzaris, Pascal Juillerat, Tamas Molnar, Krisztina B. Gecse, Joana Torres, Pär Myrelid, Uma Mahadevan, Juan Ricardo Márquez, Beatriz Maria Iade‐Vergara, Astrid Rausch, Dana Duricova, Mette Julsgaard, María Chaparro   +30 more
wiley   +1 more source

Benefit of Filgotinib, a JAK1 Preferential Inhibitor, in Rheumatoid Arthritis Patients with Previous Rapid Radiographic Progression: Post Hoc Analysis of Two Trials

Rheumatology and Therapy, 2022
Introduction We conducted a post hoc analysis of efficacy and safety of filgotinib stratified by estimated radiographic progression rate before baseline (BL) in patients with rheumatoid arthritis (RA) who had inadequate response to methotrexate (MTX ...
Yoshiya Tanaka, Tatsuya Atsumi, Daniel Aletaha, Beatrix Bartok, Alena Pechonkina, Ling Han, Kahaku Emoto, Shungo Kano, Vijay Rajendran, Tsutomu Takeuchi   +9 more
doaj   +1 more source

Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement [PDF]

, 2020
Objectives: Janus kinase inhibitors (JAKi) have been approved for use in various immune-mediated inflammatory diseases. With five agents licensed, it was timely to summarise the current understanding of JAKi use based on a systematic literature review ...
Aletaha, D, Baraliakos, X, Boehncke, W-H, de Wit, M, Dougados, M, Dörner, T, Emery, P, Fleischmann, RM, Geissler, K, Isaacs, JD, Kerschbaumer, A, Kremer, J, Lee, EB, Maksymowych, WP, McInnes, I, Nash, P, Pope, JE, Smolen, JS, Stoffer-Marx, M, Takeuchi, T, Tam, L-S, Tanaka, Y, Trauner, M, van den Bosch, F, van der Heijde, D, Voshaar, M, Westhovens, R, Winthrop, KL, Xavier, R   +28 more
core   +4 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Long-term safety and efficacy of filgotinib for the treatment of moderately to severely active ulcerative colitis: Interim analysis from up to 4 years of follow-up in the SELECTION open-label long-term extension study [PDF]

BACKGROUND Filgotinib, an oral, once-daily, Janus kinase 1 preferential inhibitor, is an approved treatment for moderately to severely active ulcerative colitis.
Beales, Ian, Danese, Silvio, de Haas, Angela, Faes, Margaux, Feagan, Brian G, Kim, Hyo Jong, Laharie, David, Loftus, Edward V, Masior, Tomasz, Matsuoka, Katsuyoshi, Peyrin-Biroulet, Laurent, Rogler, Gerhard, Rudolph, Christine, Schreiber, Stefan, Vermeire, Séverine   +14 more
core   +1 more source

Cocaine-induced granulomatosis with polyangiitis—an under-recognized condition [PDF]

, 2023
Objectives: Cocaine and cocaine mixed with levamisole are increasingly used in the UK and result in significant direct nasal damage in addition to promoting vasculitis.
Burns, Aine, Chanouzas, Dimitrios, Gane, Simon, Gill, Charn, Hamour, Sally, Harper, Lorraine, Henderson, Scott R, Mcclelland, Lisha, Ozbek, Leyla, Pepper, Ruth J, Salama, Alan D, Sturman, Joseph   +11 more
core