Results 1 to 10 of about 859 (110)
Myosin-X and talin modulate integrin activity at filopodia tips
Cell Reports, 2021 Summary: Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined.
Mitro Miihkinen +2 more
exaly +3 more sources
Biomolecules, 2023 The actin nucleating and polymerizing formin-like 2 (FMNL2) is upregulated in several cancers and has been shown to play important roles in cell migration, invasion, cell–cell adhesion and filopodia formation.
Robert Grosse +2 more
exaly +3 more sources
Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia
Cell Reports, 2019 Summary: Microglia, the brain’s immune cells, maintain homeostasis and sense pathological changes by continuously surveying the parenchyma with highly motile large processes.
Louis-Philippe Bernier +2 more
exaly +3 more sources
Regulation of dendritic filopodial interactions by ZO-1 and implications for dendrite morphogenesis. [PDF]
PLoS ONE, 2013 Neuronal dendrites dynamically protrude many fine filopodia in the early stages of neuronal development and gradually establish complex structures. The importance of the dendritic filopodia in the formation of axo-dendritic connections is established ...
Ryouhei Komaki +2 more
doaj +1 more source
Cells, 2023 Background: Filopodia are dynamic, finger-like actin-filament bundles that overcome membrane tension by forces generated through actin polymerization at their tips to allow extension of these structures a few microns beyond the cell periphery.
Jens Ingo Hein +4 more
doaj +1 more source
Proteins that promote filopodia stability, but not number, lead to more axonal-dendritic contacts. [PDF]
PLoS ONE, 2011 Dendritic filopodia are dynamic protrusions that are thought to play an active role in synaptogenesis and serve as precursors to spine synapses.
Pamela Arstikaitis +4 more
doaj +1 more source
VASP-mediated actin dynamics activate and recruit a filopodia myosin
eLife, 2021 Filopodia are thin, actin-based structures that cells use to interact with their environments. Filopodia initiation requires a suite of conserved proteins but the mechanism remains poorly understood. The actin polymerase VASP and a MyTH-FERM (MF) myosin,
Ashley L Arthur +3 more
doaj +1 more source
Maturation of filopodia shaft adhesions is upregulated by local cycles of lamellipodia advancements and retractions. [PDF]
PLoS ONE, 2014 While cell-substrate adhesions that form between the protruding edge of a spreading cell and flat surfaces have been studied extensively, processes that regulate the maturation of filopodia adhesions are far less characterized.
Wei Hu +2 more
doaj +1 more source
Biomechanical Aspects of Actin Bundle Dynamics
Frontiers in Cell and Developmental Biology, 2020 Lamellipodial and filopodial protrusions are two of the main aggregate types of filamentous actin in living cells. Even though filopodia are essential to a range of vital cell functions, the mechanisms leading to their formation are still debated ...
Julia Lange +2 more
doaj +1 more source
Cell Communication and Signaling, 2023 Macrophage filopodia, which are dynamic nanotube-like protrusions, have mainly been studied in the context of pathogen clearance. The mechanisms by which they facilitate intercellular communication and mediate tissue inflammation remain poorly understood.
Xiaodong Zhu +6 more
doaj +1 more source