Results 11 to 20 of about 35,622 (198)

Arp2/3 complex activity in filopodia of spreading cells [PDF]

BMC Cell Biology, 2008
Background Cells use filopodia to explore their environment and to form new adhesion contacts for motility and spreading. The Arp2/3 complex has been implicated in lamellipodial actin assembly as a major nucleator of new actin filaments in branched ...
Mendes Paula M, Yeung Chun L, Bramble Jonathan P, Johnston Simon A, Machesky Laura M   +4 more
doaj   +3 more sources

Islands of conformational stability for filopodia. [PDF]

PLoS ONE, 2013
Filopodia are long, thin protrusions formed when bundles of fibers grow outwardly from a cell surface while remaining closed in a membrane tube.
D Robert Daniels, Matthew S Turner
doaj   +3 more sources

Secreted exosomes induce filopodia formation [PDF]

eLife
Filopodia are dynamic adhesive cytoskeletal structures that are critical for directional sensing, polarization, cell-cell adhesion, and migration of diverse cell types. Filopodia are also critical for neuronal synapse formation.
Caitlin McAtee, Mikin R Patel, Daisuke Hoshino, Bong Hwan Sung, Ariana K von Lersner, Mingjian Shi, Nan Hyung Hong, Anna Young, Evan Krystofiak, Andries Zijlstra, Alissa M Weaver   +10 more
doaj   +2 more sources

Semi-automatic geometrical reconstruction and analysis of filopodia dynamics in 4D two-photon microscopy images [PDF]

BMC Bioinformatics
Background Filopodia are thin and dynamic membrane protrusions that play a crucial role in cell migration, axon guidance, and other processes where cells explore and interact with their surroundings. Historically, filopodial dynamics have been studied in
Blaž Brence, Josephine Brummer, Vincent J. Dercksen, Mehmet Neset Özel, Abhishek Kulkarni, Neele Wolterhoff, Steffen Prohaska, Peter Robin Hiesinger, Daniel Baum   +8 more
doaj   +3 more sources

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation

Communications Biology
Amphiphysin 2 (BIN1) is a membrane and actin remodeling protein mutated in congenital and adult centronuclear myopathies. Here, we report an unexpected function of this N-BAR domain protein BIN1 in filopodia formation.
Laura Picas, Charlotte André-Arpin, Franck Comunale, Hugo Bousquet, Feng-Ching Tsai, Félix Rico, Paolo Maiuri, Julien Pernier, Stéphane Bodin, Anne-Sophie Nicot, Jocelyn Laporte, Patricia Bassereau, Bruno Goud, Cécile Gauthier-Rouvière, Stéphanie Miserey   +14 more
doaj   +2 more sources

Macropinocyosis filopodia

, 2022
Avi movie showing activity-dependent filopodia formation (measured using GPI-GFP) co-incident with SV exocytosis (measured using syp-mOr2).Cousin, Michael. (2022). Macropinocyosis filopodia, [moving image]. University of Edinburgh.
Centre for Discovery Brain Sciences, Cousin, Michael; id_orcid   +1 more
core   +2 more sources

Myosin-X recruits lamellipodin to filopodia tips [PDF]

, 2023
Myosin-X (MYO10), a molecular motor localizing to filopodia, is thought to transport various cargo to filopodia tips, modulating filopodia function. However, only a few MYO10 cargoes have been described. Here, using GFP-Trap and BioID approaches combined
Goult, Benjamin T, Goult, BT, Popović, A, Ghimire, S, Miihkinen, Mitro, Ivaska, Johanna, Jacquemet, G, Miihkinen, M, Grönloh, MLB, Popović, Ana, Ball, NJ, Ghimire, Sujan, Ball, Neil J., Ivaska, J, Saup, R, Grönloh, Max L.B., Jacquemet, Guillaume   +16 more
core   +1 more source

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia [PDF]

, 2003
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately ...
Shima, D., Christiana Ruhrberg, Betsholtz, C, Jeltsch, M, Abramsson, A., Shima, D, Matthew Golding, Lundkvist, A, Lundkvist, A., Golding, M, David Shima, Ruhrberg, C, Christopher Mitchell, Mitchell, C, Betsholtz, C., Kari Alitalo, Gerhardt, H, Ruhrberg, C., Christer Betsholtz, Golding, M., Jeltsch, M., Holger Gerhardt, Abramsson, A, Alitalo, K, Andrea Lundkvist, Fruttiger, M., Gerhardt, H., Alitalo, K., Alexandra Abramsson, Mitchell, C., Fruttiger, M, Michael Jeltsch, Marcus Fruttiger   +32 more
core   +1 more source

Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model. [PDF]

PLoS ONE, 2011
F-actin networks are important structural determinants of cell shape and morphogenesis. They are regulated through a number of actin-binding proteins.
Catarina Gonçalves-Pimentel, Rita Gombos, József Mihály, Natalia Sánchez-Soriano, Andreas Prokop   +4 more
doaj   +1 more source

Chiral growth of adherent filopodia

, 2023
Adherent filopodia are elongated finger-like membrane protrusions, extending from the edges of diverse cell types and participating in cell adhesion, spreading, migration, and environmental sensing. The formation and elongation of filopodia are driven by
Bershadsky, Alexander D, Kozlov, Michael M, Chung, Wen-Lu; https://orcid.org/, Li, Wenhong, Medalia, Ohad; https://orcid.org/, Geiger, Benjamin; https://orcid.org/   +5 more
core   +1 more source