Results 21 to 30 of about 5,165 (182)

Filoviridae: insights into immune responses to Ebola virus

Exploration of Immunology
Ebola virus (EBOV) is a zoonotic virus comprising of six known different species, designated within the family Filoviridae and genus Ebolavirus. The first recorded outbreak of an EBOV disease (EVD) was in Yambuku, Zaire EBOV (ZEBOV) in 1976, followed by ...
Brent Brown, Chinua Imarogbe, Enrique Chacon-Cruz, Ingo Fricke   +3 more
doaj   +2 more sources

Climate Change-Driven Heatwaves Pose Lethal Risks to Newborn Forest Bats. [PDF]

Ecol Evol
This is the first recorded case of forest bat mortality in temperate regions caused by heatwaves. The study suggests that forest fragmentation exposes bats to lethal thermal peaks, highlighting a previously overlooked impact of climate change on these mammals and potential interactions with forest fragmentation.
Russo D, Mäenurm A, Cistrone L, Martinoli A, Foiani G, Giongo V, Leopardi S.   +6 more
europepmc   +2 more sources

Marburg Virus Disease: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Letafati A, Fakhr SSH, Najafabadi AQ, Karami N, Karami H.   +4 more
europepmc   +2 more sources

The New Members of Filoviridae Family: Distribution, Natural Reservoirs, Potential Epidemic Danger

Вестник войск РХБ защиты, 2023
The purpose of the work is to analyze the distribution, natural reservoirs and potential epidemic hazard of new members of the Filoviridae family – Bombali viruses (genus Ebolavirus), Lloviu (genus Cuevavirus), Mengla (genus Dianlovirus), Xylang (genus ...
T. E. Sizikova, N. V. Boyarskaya, A. V. Kovalchuk, V. N. Lebedev, S. V. Borisevich   +4 more
doaj   +1 more source

Predicting the combined effects of case isolation, safe funeral practices, and contact tracing during Ebola virus disease outbreaks.

PLoS ONE, 2023
BackgroundThe recent outbreaks of Ebola virus disease (EVD) in Uganda and the Marburg virus disease (MVD) in Ghana reflect a persisting threat of Filoviridae to the global health community.
Aliou Bouba, Kristina Barbara Helle, Kristan Alexander Schneider   +2 more
doaj   +1 more source

Computational Modeling and Evaluation of Potential mRNA and Peptide-Based Vaccine against Marburg Virus (MARV) to Provide Immune Protection against Hemorrhagic Fever

BioMed Research International, 2023
A hemorrhagic fever caused by the Marburg virus (MARV) belongs to the Filoviridae family and has been classified as a risk group 4 pathogen. To this day, there are no approved effective vaccinations or medications available to prevent or treat MARV ...
Faisal F. Albaqami, A. Altharawi, H. Althurwi, Khalid M. Alharthy, M. Qasim, Ziyad Tariq Muhseen, Muhammad Tahir ul Qamar   +6 more
semanticscholar   +1 more source

Evaluation of a Luminex-Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal. [PDF]

Transbound Emerg Dis
Given the growing threat posed by viral hemorrhagic fevers, the development of surveillance tools is crucial to provide accurate and rapid solutions. Public health response involves risk assessment as well as effective and sustainable surveillance to ensure downstream communication and preparedness. A serological approach that offers high precision and
Sankhe S, Diarra M, Barry MA, Faye M, Talla C, Camara D, Mbanne M, Sembene PM, Sall AA, Fall G, Faye O, Loucoubar C, Faye O, Vigan-Womas I, Ricks KM, Radzio-Basu J, Diagne MM.   +16 more
europepmc   +2 more sources

Combination therapy protects macaques against advanced Marburg virus disease

Nature Communications, 2021
Monoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae), and more recently, SARS-CoV-2.
R. Cross, Z. Bornholdt, A. Prasad, V. Borisevich, K. Agans, D. Deer, Dafna M. Abelson, Do H. Kim, W. Shestowsky, L. Campbell, Elaine Bunyan, J. Geisbert, Karla A. Fenton, L. Zeitlin, D. Porter, T. Geisbert   +15 more
semanticscholar   +1 more source

Remdesivir (GS-5734) Impedes Enterovirus Replication Through Viral RNA Synthesis Inhibition

Frontiers in Microbiology, 2020
Human enteroviruses are responsible for diverse diseases, from mild respiratory symptoms to fatal neurological complications. Currently, no registered antivirals have been approved for clinical therapy.
Wei Ye, Min Yao, Yangchao Dong, Chuantao Ye, Dan Wang, He Liu, Hongwei Ma, Hui Zhang, Libin Qi, Yuewu Yang, Yuan Wang, Liang Zhang, Linfeng Cheng, Xin Lv, Zhikai Xu, Yingfeng Lei, Fanglin Zhang   +16 more
doaj   +1 more source

Marburg virus outbreak in Tanzania: A threat to global health security

Public Health Challenges, Volume 2, Issue 4, December 2023., 2023
Abstract The current Marburg virus (MARV) outbreak in Tanzania served as a stark reminder of the ongoing threat posed by emerging infectious diseases and the urgent need for global health security. The Tanzanian Ministry of Health (MoH) officially declared the outbreak on March 21, 2023.
Majani Edward, Godfred Yawson Scott, Withness John, Martha Ernest Rajabu, Elton Mahulu, Shuaibu Saidu Musa, Lucero‐Prisno III Don Eliseo   +6 more
wiley   +1 more source