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Emerging and reemerging of filoviruses
1996Filoviruses are causative agents of a hemorrhagic fever in man with mortalities ranging from 22 to 88%. They are enveloped, nonsegmented negative-stranded RNA viruses and are separated into two types, Marburg and Ebola, which can be serologically, biochemically and genetically distinguished. In general, there is little genetic variability among viruses
H, Feldmann, W, Slenczka, H D, Klenk
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Fighting filoviruses with antibody therapy
Science, 2017Emerging Infections Ravn and Marburg viruses cause hemorrhagic fever with high morbidity rates in humans. Mire et al. tested the ability of previously identified human monoclonal antibodies to protect guinea pigs from lethal infection. One candidate antibody was administered 5 days after otherwise lethal Marburg or Ravn infection in nonhuman primates ...
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Live-Cell Imaging of Filoviruses
2017Observation of molecular processes inside living cells is fundamental to a deeper understanding of virus-host interactions in filoviral-infected cells. These observations can provide spatiotemporal insights into protein synthesis, protein-protein interaction dynamics, and transport processes of these highly pathogenic viruses.
Gordian, Schudt +2 more
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Vaccine research efforts for filoviruses
International Journal for Parasitology, 2003Ebola and Marburg viruses belong to the family Filoviridae, and cause acute, frequently fatal, haemorrhagic fever in humans and non-human primates. No vaccines are available for human use. This review describes the status of research efforts to develop vaccines for these viruses and to identify the immune mechanisms of protection.
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Minigenome Systems for Filoviruses
2017Filoviruses are among the most pathogenic viruses known to man, and work with live viruses is restricted to maximum containment laboratories. In order to study individual aspects of the virus life cycle outside of maximum containment laboratories, life cycle modeling systems have been established, which use reporter-encoding miniature versions of the ...
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Filoviruses as emerging pathogens
Seminars in Virology, 1994Abstract Of all the animal virus families that cause disease in man least is known about members of Filoviridae. This family, which contains Marburg and Ebola viruses, is one member of the order Mononegavirales, RNA viruses with a single negative genomic strand. The natural history of the filoviruses is unknown, but they have on occasion caused small
C.J. Peters +5 more
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Reverse Genetics Systems for Filoviruses
2017Filoviruses are among the most pathogenic viruses known to man. Reverse genetics systems, in particular full-length clone systems, allow the generation of recombinant filoviruses, which can be used to study virus biology, but also for applied uses such as screening for countermeasures.
Thomas, Hoenen, Heinz, Feldmann
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Inside the Cell: Assembly of Filoviruses
2017This chapter reviews our current knowledge about the spatiotemporal assembly of filoviral particles. We will follow particles from nucleocapsid entry into the cytoplasm until the nucleocapsids are enveloped at the plasma membrane. We will also highlight the currently open scientific questions surrounding filovirus assembly.
Larissa, Kolesnikova +3 more
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2018
Congenital and pediatric Ebola virus disease (EVD) and Marburg virus disease (MVD) are severe, even lethal infections. Historically, children have been underrepresented in filovirus disease outbreaks, and evidence-based treatment strategies are lacking. Existing data suggest that case fatalities are highest among children under four years of age, which
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Congenital and pediatric Ebola virus disease (EVD) and Marburg virus disease (MVD) are severe, even lethal infections. Historically, children have been underrepresented in filovirus disease outbreaks, and evidence-based treatment strategies are lacking. Existing data suggest that case fatalities are highest among children under four years of age, which
openaire +1 more source