Results 111 to 120 of about 13,264 (267)

Exploring dangerous connections between Klebsiella pneumoniae biofilms and healthcare-associated infections [PDF]

, 2014
Healthcare-associated infections (HAI) are a huge public health concern,particularly when the etiological agents are multidrug resistant. The ability of bacteria to develop biofilm is a helpful skill, both to persist within hospital units and to ...
Bandeira, Maria, Carvalho, Patricia Almeida, Duarte, Aida, Jordão, Luísa   +3 more
core   +2 more sources

Sugars in Antimicrobial Polymers – The Impact of Sugar‐Lectin Binding in Membrane Interaction of Cationic Glycopolymers

Advanced Materials Interfaces, Volume 12, Issue 16, August 18, 2025.
Photo‐iniferter polymerization is used to create antimicrobial polymers which are decorated with sugar units by either copolymerization of glycomonomers or post‐polymerization functionalization. Although a selectivity based on lectin binding can not be observed, the presence of sugar leads to improved bioactivity based on the presence of neutral ...
Alain M. Bapolisi, Steffen Tank, Anne‐Catherine Lehnen, Antje Stindt, Rujuta Athavale, Jan A. M. Kurki, Sany Chea, Sophia Rosencrantz, Ruben R. Rosencrantz, Katja M. Arndt, Matthias Hartlieb   +10 more
wiley   +1 more source

On board sampling of the rockfish and lingcod commerical passenger fishing vessel industry in northern and central California, May 1987 to December 1991 [PDF]

, 1993
From May 1987 to June 1990 and from August to December 1991 Fishery Technicians sampled catches on board 690 Commercial Passenger Fishing Vessel (CPFV) trips targeting rockfish and lingcod from the general port areas of Fort Bragg, Bodega Bay, San ...
Hardwick, James E., Reilly, Paul N., Short, Duncan, Watters, Diana L., Wilson-Vandenberg, Deb   +4 more
core  

Structures of C-mannosylated anti-adhesives bound to the type 1 fimbrial FimH adhesin

IUCrJ, 2016
Selective inhibitors of the type 1 fimbrial adhesin FimH are recognized as attractive alternatives for antibiotic therapies and prophylaxes against Escherichia coli infections such as urinary-tract infections.
Jerome de Ruyck, Marc F. Lensink, Julie Bouckaert   +2 more
doaj   +1 more source

Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131 [PDF]

, 2018
Background. Epidemiological studies point to the gut as a key reservoir of multidrug resistant Escherichia coli multilocus sequence type 131 (ST131), a globally dominant pathogenic clone causing urinary tract and bloodstream infections.
Altenhoefer, Banerjee, Ben Zakour, Blanc, Boltin, Datsenko, Dena Lyras, Dimitrios Vagenas, Dreux, Foxman, Freter, Golan, Göttke, Imuta, Johnson, Kakkanat, Krogfelt, Krogfelt, Laukoetter, Lewis, Lo, Madigan, Makrina Totsika, Mark A Schembri, McCormick, McCormick, Meador, Melanie L Hutton, Nicolas-Chanoine, Nicolas-Chanoine, Nielsen, Ofek, O’Brien, Peirano, Petty, Poole, R Development Core Team, Rinaldo Ruter, Sarkar, Sarkar, Sarkar, Schembri, Sohinee Sarkar, Spaulding, Stephanie Schüller, Totsika, Totsika, Vimont, Wood   +48 more
core   +1 more source

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists [PDF]

Journal of Medicinal Chemistry, 2010
FimH-mediated cellular adhesion to mannosylated proteins is critical in the ability of uropathogenic E. coli (UPEC) to colonize and invade the bladder epithelium during urinary tract infection. We describe the discovery and optimization of potent small-molecule FimH bacterial adhesion antagonists based on alpha-d-mannose 1-position anomeric glycosides ...
Zhenfu, Han, Jerome S, Pinkner, Bradley, Ford, Robert, Obermann, William, Nolan, Scott A, Wildman, Doug, Hobbs, Tom, Ellenberger, Corinne K, Cusumano, Scott J, Hultgren, James W, Janetka   +10 more
openaire   +2 more sources

A Modular Solid Phase Synthesis Approach for Glycocalix[4]Arene Derivatives and Their Multivalent Presentation on Ultrasmall Gold Nanoparticles.

Chemistry – A European Journal, Volume 31, Issue 40, July 17, 2025.
In this study, we present a calix[4]arene building block suitable for modular solid‐phase polymer synthesis and the preparation of functional glycocalix[4]arene. This allows us to incorporate carbohydrate ligands and further functionalities, such as alkynes at a specific position at the upper or lower rim of the calix[4]arene as demonstrated for the ...
Alisa Kayser, Kai Klein, Daria Babushkina, Anne Sakse, Gisele Mouafo Kenne, Ulla I.M. Gerling‐Driessen, Monir Tabatabai, Matthias Epple, Laura Hartmann   +8 more
wiley   +1 more source

Targeting Dynamical Binding Processes in the Design of Non-Antibiotic Anti-Adhesives by Molecular Simulation—The Example of FimH

Molecules, 2018
Located at the tip of type I fimbria of Escherichia coli, the bacterial adhesin FimH is responsible for the attachment of the bacteria to the (human) host by specifically binding to highly-mannosylated glycoproteins located on the exterior of the host ...
Eva-Maria Krammer, Jerome de Ruyck, Goedele Roos, Julie Bouckaert, Marc F. Lensink   +4 more
doaj   +1 more source

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Nature, 2017
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) affect 150 million people annually. Despite effective antibiotic therapy, 30–50% of patients experience recurrent UTIs.
Caitlin N. Spaulding, R. Klein, S. Ruer, A. Kau, H. Schreiber, Zachary T. Cusumano, K. Dodson, J. Pinkner, D. Fremont, J. Janetka, H. Remaut, J. Gordon, S. Hultgren   +12 more
semanticscholar   +1 more source

Forging a New Frontier: Antimicrobial Peptides and Nanotechnology Converging to Conquer Gastrointestinal Pathogens

Small, Volume 21, Issue 26, July 3, 2025.
This review explores the potential of antimicrobial peptides (AMPs) and nanotechnology for the treatment of gastrointestinal infections. It analyzes bacterial resistance mechanisms, the antimicrobial actions of AMPs, and advances in nanocarriers, such as lipid‐based, polymeric, metallic, and mesoporous silica systems, that enhance peptide protection ...
Christian Shleider Carnero Canales, Cesar Augusto Roque‐Borda, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Uner Josseph Pinto Apaza, Vanderson de Jesus Silva, Laura Maria Duran Gleriani Primo, Maura Jennifer Martínez‐Morales, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +10 more
wiley   +1 more source