Results 61 to 70 of about 529,949 (323)

Reducing the fine-tuning of gauge-mediated SUSY breaking [PDF]

, 2016
Despite their appealing features, models with gauge-mediated supersymmetry breaking (GMSB) typically present a high degree of fine-tuning, due to the initial absence of the top trilinear scalar couplings, $A_t=0$.
Casas, J. Alberto, Moreno, Jesus M., Robles, Sandra, Rolbiecki, Krzysztof   +3 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Fine-Tuning S1P Therapeutics

Chemistry & Biology, 2012
Sphingosine 1-phosphate receptor-1 (S1P(1)), a novel therapeutic target for multiple sclerosis, regulates lymphocyte trafficking, heart rate, and vascular function. The discovery of NIBR-0213, a competitive antagonist for S1P(1) that inhibits autoimmune inflammation while sparing bradycardia (Quancard et al., in this issue of Chemistry & Biology ...
Obinata, Hideru, Hla, Timothy
openaire   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Fine-tuning protein language models boosts predictions across diverse tasks

Nature Communications
Prediction methods inputting embeddings from protein language models have reached or even surpassed state-of-the-art performance on many protein prediction tasks.
Robert Schmirler, Michael Heinzinger, Burkhard Rost   +2 more
doaj   +1 more source

2DOF multi-objective optimal tuning of disturbance reject fractional order PIDA controllers according to improved consensus oriented random search method

Journal of Advanced Research, 2020
This study presents a Fractional Order Proportional Integral Derivative Acceleration (FOPIDA) controller design methodology to improve set point and disturbance reject control performance.
Necati Ozbey, Celaleddin Yeroglu, Baris Baykant Alagoz, Norbert Herencsar, Aslihan Kartci, Roman Sotner   +5 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Zasada szczególnego dostrojenia w kontekście układów z chaosem deterministycznym

Zagadnienia Filozoficzne w Nauce, 2008
From the beginning of the deterministic chaos research, the unpredictability has been its central theme. Interesting questions arise here: What are the consequences of chaos for the fine tuned processes? Are there fine tuning systems in reality?
Bartłomiej Brus, Marek Szydłowski
doaj  

Fine-Tuned of Necessity? [PDF]

Res Philosophica, 2018
This paper seeks to explicate and analyze an alternative response to fine-tuning arguments from those that are typically given—namely, design or brute contingency. The response I explore is based on necessity, the necessitarian response. After showing how necessity blocks the argument, I explicate the reply I claim necessitarians can give and suggest ...
openaire   +3 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source