Crystallization of Feline Coronavirus Mpro With GC376 Reveals Mechanism of Inhibition
Frontiers in Chemistry, 2022 Coronaviruses infect a variety of hosts in the animal kingdom, and while each virus is taxonomically different, they all infect their host via the same mechanism.
Jimmy Lu +15 more
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Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats. [PDF]
, 2012 Feline infectious peritonitis virus (FIPV) was presumed to arise from mutations in the 3c of a ubiquitous and largely nonpathogenic feline enteric coronavirus (FECV).
Golovko, Lyudmila +6 more
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Epicarditis in a cat caused by feline infectious peritonitis virus: case report [PDF]
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2020 Feline Infectious Peritonitis (FIP) is a progressive and fatal disease in domestic and wild cats, caused by Feline Infectious Peritonitis Virus (FIPV). The disease is characterized by an immunomediated reaction against the virus in various organs.
G.A. Araujo +4 more
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Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection. [PDF]
, 2015 Twenty specific pathogen free cats were experimentally infected with a virulent cat-passaged type I field strain of FIPV. Eighteen cats succumbed within 2-4 weeks to effusive abdominal FIP, one survived for 6 weeks, and one seroconverted without outward ...
Eckstrand, Chrissy +4 more
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Viruses, 2021 Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs through respiratory droplets passed directly from person to person or indirectly through fomites, such as common use surfaces or objects. The aim of this study was to
Amanda Gardner +3 more
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Broad-Spectrum Antiviral Activity of the Orally Bioavailable Antiviral ATV014 Against Multiple Coronaviruses. [PDF]
MedComm (2020)MedComm, Volume 6, Issue 5, May 2025.
Yang S, Li K, Zhou Q, Zhang X, Guo D.
europepmc +2 more sources
Virology, 2007 The pathogenicity of feline infectious peritonitis virus (FIPV) is known to depend on macrophage tropism, and this macrophage infection is enhanced by mediation via anti-S antibody (antibody-dependent enhancement, ADE). In this study, we found that TNF-alpha production was increased with viral replication in macrophages inoculated with a mixture of ...
Takano, Tomomi +4 more
openaire +2 more sources
The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. [PDF]
, 2018 Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats. Recent studies of diseases caused by several RNA viruses in people and other species indicate that antiviral therapy may be effective against FIP in ...
Bauer, K +7 more
core +1 more source
Comparative sequence analysis of full-length genome of FIPV at different tissue passage levels [PDF]
Virus Genes, 2013 Feline infectious peritonitis virus (FIPV), an alpha Coronavirus, is the causative agent of a fatal immune mediated disease in cats. It is currently unclear if this virus circulates in the field or develops in felines that are infected with Feline enteric coronavirus.
Phillips, J. E. +2 more
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Ultrastructure of SARS-CoV, FIPV, and MHV Revealed by Electron Cryomicroscopy [PDF]
, 2006 * The Scripps Research Institute, La Jolla, California. The current understanding of coronavirus ultrastructure relies heavily on transmission electron microscopy of negatively stained images. Such images typically show desiccated specimens and derive contrast from the accumulation of heavy metal negative stains, distorting the sample in the resulting ...
Neuman, Benjamin W. +6 more
openaire +2 more sources