Results 171 to 180 of about 394,837 (342)

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

INFLUENCE OF ROOTSTOCKS AND STORAGE CONDITIONS ON THE QUALITY OF SWEET CHERRY FRUITS ‘REGINA’

open access: yesActa Scientiarum Polonorum: Hortorum Cultus, 2016
Rootstock modifies many fruits features during growth and cropping trees in the orchard. Studies were undertaken to prove the effect of rootstock on the quality of sweet cherry ‘Regina’ fruit before and after storage period.
Ewa Dziedzic   +2 more
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

QUALITY FEATURES OF PARTHENOCARPIC PEARS COLLECTED FROM TREES GROWN ON DIFFERENT ROOTSTOCKS

open access: yesActa Scientiarum Polonorum: Hortorum Cultus, 2015
In countries where spring frost frequently causes damage to pear flowers, cropping is possible through natural and induced parthenocarpy. The tendency to bear parthenocarpic fruit is a genetic feature so it differs between cultivars.
Grzegorz P. Łysiak, Wojciech Antkowiak
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

EFFECT OF AMINOETHOXYVINYLGLYCINE (AVG) ON THE QUALITY OF JAPANESE PLUM (Prunus salicina Lindell cv. Fortune) FRUITS

open access: yesActa Scientiarum Polonorum: Hortorum Cultus, 2015
The role of pre-harvest aminoethoxyvinylglycine (AVG) treatments on bioac-tive compounds, fruit ripening and quality of Japanese plum fruits (Prunus salicina Lin-dell cv. ‘Fortune’) were investigated in this study.
Emine Kucuker   +3 more
doaj  

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