Results 91 to 100 of about 60,314 (290)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Modelling of Highway Runoff Quantity and Quality

Acta Polytechnica, 2001
The stormwater Management Model (SWMM) is a well-known stormwater runoff-simulation model. It is a deterministic, spatially distributed model for calculation of runoff quantity and quality.
Ashraf El-Shahat Elsayed, A. Grünwald, M. Synáčková, M. Slavíček   +3 more
doaj  

Design and operation of a high-heat flux, flush-mounted ‘rail’ Langmuir probe array on Alcator C-Mod

Nuclear Materials and Energy, 2017
A poloidal array of toroidally-extended, flush-mounted ‘rail’ Langmuir probes was recently installed on Alcator C-Mod's vertical target plate divertor. The aim was to investigate if a Langmuir probe array could be designed to survive reactor-level heat ...
A.Q. Kuang, D. Brunner, B. LaBombard, R. Leccacorvi, R. Vieira   +4 more
doaj   +1 more source

[Causes and differential diagnosis of flush.]

, 2013
International audience: The flush is a transient and recurrent erythema of the upper region of the body, due to a sudden arterial dilatation. First, physicians should confirm the flush and ascertain the location and timing of skin manifestations.
Lecornet-Sokol, E., Lafont, E., Hermine, O., Georgin-Lavialle, S., Sokol, H., Barete, S., Pouchot, J., Sarre-Annweiler, M.-E.   +7 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Bioaerosol concentrations generated from toilet flushing in a hospital-based patient care setting

Antimicrobial Resistance and Infection Control, 2018
Background In the United States, 1.7 million immunocompromised patients contract a healthcare-associated infection, annually. These infections increase morbidity, mortality and costs of care.
Samantha D. Knowlton, Corey L. Boles, Eli N. Perencevich, Daniel J. Diekema, Matthew W. Nonnenmann, CDC Epicenters Program   +5 more
doaj   +1 more source

Analysis of first flush to improve the water quality in rainwater tanks

Water Science and Technology, 2010
Although most Australians receive their domestic supply from reticulated mains or town water, there are vast areas with very low population densities and few reticulated supplies. In many of these areas rainwater collected in tanks is the primary source of drinking water.
B, Kus, J, Kandasamy, S, Vigneswaran, H K, Shon   +3 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source