Results 71 to 80 of about 2,712,702 (297)

Rapid recreation assessment: a tool to assess visitor use and associated impacts at coastal and marine protected areas [PDF]

open access: yes, 2006
As more people discover coastal and marine protected areas as destinations for leisure-time pursuits, the task of managing coastal resources while providing opportunities for high quality visitor experiences becomes more challenging.
Denny, Christine, Fish, Thomas E.
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A natural cure for the pet fish problem: feature emergence as classificatory composition [PDF]

open access: yes, 2013
Where do emergent features come from? This has long been an intriging puzzle. The concept of pet fish illustrates the difficulty. Most people expect pet fish to live in bowls, even though this is not something either pets or fish normally do.
Thornton, Chris
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multiple scales of biological variability in New Zealand streams : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Ecology at Massey University, Manawatū, New Zealand [PDF]

open access: yes, 2016
Stream fish communities in Taranaki, New Zealand, were studied for the patterns and drivers of their spatial ecology. The study was focused on three main themes: a) complementarity between geography and landuse in driving regional distribution patterns ...
Jayasuriya
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Fish assemblages found in tidal-creek and seagrass habitats in the Suwannee River estuary [PDF]

open access: yes, 2006
Fish assemblages were investigated in tidal-creek and seagrass habitats in the Suwannee River estuary, Florida. A total of 91,571 fish representing 43 families were collected in monthly seine samples from January 1997 to December 1999.
Dehaven, Mark, Tuckey, Troy D.
core   +1 more source

Gender and innovation processes in integrated fish agri-food systems in Bangladesh and the Philippines: Insights from the CGIAR Research Program on FISH [PDF]

open access: yes, 2020
This FISH report provides insights on the interactions between gender norms, agency, and innovation in fish agri-food ...
Aregu, Lemlem   +4 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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