Results 71 to 80 of about 1,708,559 (358)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

open access: yesFEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker   +9 more
wiley   +1 more source

Calibrating minimum counts and catch‐per‐unit‐effort as indices of moose population trend

open access: yesWildlife Society Bulletin, 2016
Monitoring wildlife population trends often involves indices assumed to correlate in proportion to abundance. We used aerial count data and harvest statistics for moose (Alces alces) populations in 16 hunting districts of Montana, USA, spanning 32 years (
Nicholas J. DeCesare   +7 more
doaj   +1 more source

Dual Mode Logic—Design for Energy Efficiency and High Performance

open access: yesIEEE Access, 2013
The recently proposed dual mode logic (DML) gates family enables a very high level of energy-delay optimization flexibility at the gate level. In this paper, this flexibility is utilized to improve energy efficiency and performance of combinatorial ...
Itamar Levi, Alexander Fish
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Myth debunked: Keratinous pangolin scales do not contain the analgesic tramadol

open access: yesConservation Science and Practice, 2019
Conservation plans aiming to reduce the threat of illegal wildlife trade increasingly recognize the need for multifaceted approaches that include both enhanced enforcement and demand reduction initiatives.
Rachel L. Jacobs   +3 more
doaj   +1 more source

Cost-Effective Approach to Reducing Collisions with Elk by Fencing Between Existing Highway Structures

open access: yesHuman-Wildlife Interactions, 2017
Collisions with large ungulates cause serious human and animal injuries and significant property damage. Therefore, wildlife crossing structures are increasingly included in new road construction to reduce wildlife–vehicle collisions, while still ...
Jeffrey W. Gagnon   +5 more
doaj   +1 more source

Fishing for ancestry

open access: yeseLife, 2018
The same genes and signalling pathways control the formation of skin appendages in both fish and land animals.
Hannah Brunsdon, E Elizabeth Patton
openaire   +5 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Incremental events in the construction of sambaquis, southeastern Santa Catarina.

open access: yesRevista do Museu de Arqueologia e Etnologia, 2000
Moundbuilding is a cross-cultural phenomenon of nearly world-wide scope. In this article some of the moundbuilding processes related to the sambaquis (shellmounds) from the coast of Santa Catarina State, Brasil, are examined, focusing on field research ...
Suzanne K. Fish   +3 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

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