Results 31 to 40 of about 177,321 (314)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Linkage disequilibrium and effective population size when generations overlap

open access: yesEvolutionary Applications, 2013
Estimates of effective population size are critical for species of conservation concern. Genetic datasets can be used to provide robust estimates of this important parameter. However, the methods used to obtain these estimates assume that generations are
John D. Robinson, Gregory R. Moyer
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

On the safety management of fishing equipment and fishing technologies on sea fishing vessels

open access: yesMORSKIE INTELLEKTUAL`NYE TEHNOLOGII)</msg>, 2021
С учетом обстоятельств гибели морских рыболовных судов «Онега» (2020 г.) и «Дальний Восток» (2005 г.) выполнен обобщенный сравнительный анализ установленных нормативных требований к таким судам, включая применяемое промысловое оборудование, механизмы и устройства.
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Progress in Infertility Control Technology of Fish [PDF]

open access: hybrid, 2022
Yunsheng Zhang   +5 more
openalex   +1 more source

Working Group on Fishing Technology and Fish Behaviour (WGFTFB) [PDF]

open access: yes, 2019
The Working Group on Fishing Technology and Fish Behaviour (WGFTFB) is jointly supported by ICES and FAO, which have fostered a fruitful working relationship in an international forum. The ICES-FAO WGFTFB discusses and reviews research and practices of fishing technology and fish behaviour in relation to commercial and survey gears, and provides ...
Adam, Serena Binti   +117 more
openaire   +1 more source

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