Results 71 to 80 of about 859,212 (311)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Modern fishing technology and profitability in a second best situation [PDF]

This paper formulates a simple biomass growth model of a fishery. In this model, fish are exploited in a restricted open-access regime where a fixed number of harvesters exploit the fish stock in a myopic profit-maximizing manner. It is demonstrated that
Anders Skonhoft
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Evaluating the effect of reference genome divergence on the analysis of empirical RADseq datasets

Ecology and Evolution, 2020
The advent of high‐throughput sequencing (HTS) has made genomic‐level analyses feasible for nonmodel organisms. A critical step of many HTS pipelines involves aligning reads to a reference genome to identify variants.
Justin Bohling
doaj   +1 more source

Technology Management with Focus on Fish Transposition System (FTS) [PDF]

, 2018
Fish transposition mechanisms have been installed near hydroelectric busses in order to reconnect sections of sectioned rivers and attract fish, offering them a route for the continuity of their displacement, essential for their feeding and reproduction.
AntonioFaianoLuquez, F. (Filipe), Arenhardt, V. (Valéria), Filho, F. D. (Flávio), Martins, S. L. (Sidney), Pires, S. H. (Silvia), Silva, A. B. (Alisson)   +5 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

QUALITY CHARACTERISTICS OF TILAPIA SEAWEED BOBA DURING STORAGE [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences
Boba from previous research obtained the best formulation, namely the ratio of tapioca flour: tilapia meal: seaweed porridge = 37.5: 12.5: 50. Based on this formulation, further research is needed to determine the shelf life of tilapia seaweed boba.
Aisyah S., Khotimah I.K., Rahmawati H., Normah, Amalia J., Candra, Adawyah R.   +6 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Metabolomics-based strategies for fish meat quality, authentication and food safety: a review

Food, Nutrition and Health
Fish meat is well known for having exceptional nutritional profile, full of omega-3 fatty acids and essential amino acids which contribute to human health and disease prevention.
Pallavi Bhalavey, Sanjeev Sharma, Krishan Kumar Yadav, Rachna Gulati, Dalip Kumar Bishnoi, Nitish Bansal, Maloth Mohan, Manju Ranga, Shruthi H. U., Shrishti Sharma, Harsh Pandey, Rishi Pal Yadav, Nirmal Patel, Khushbu Gurawa   +13 more
doaj   +1 more source

Fish eye optics [PDF]

, 2017
We report on small student (high school) project of the Czech Academy of Sciences dealing with animal (fish) eyes and possible application in science and technology. Albeit most fishes have refractive eyes, the recent discoveries confirm that some fishes
Hudec R., Michalova S.
core   +1 more source