Results 71 to 80 of about 860,515 (311)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Evaluating the effect of reference genome divergence on the analysis of empirical RADseq datasets
Ecology and Evolution, 2020 The advent of high‐throughput sequencing (HTS) has made genomic‐level analyses feasible for nonmodel organisms. A critical step of many HTS pipelines involves aligning reads to a reference genome to identify variants.
Justin Bohling
doaj +1 more source
Modern fishing technology and profitability in a second best situation [PDF]
This paper formulates a simple biomass growth model of a fishery. In this model, fish are exploited in a restricted open-access regime where a fixed number of harvesters exploit the fish stock in a myopic profit-maximizing manner. It is demonstrated that
Anders Skonhoft
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
QUALITY CHARACTERISTICS OF TILAPIA SEAWEED BOBA DURING STORAGE [PDF]
Russian Journal of Agricultural and Socio-Economic SciencesBoba from previous research obtained the best formulation, namely the ratio of tapioca flour: tilapia meal: seaweed porridge = 37.5: 12.5: 50. Based on this formulation, further research is needed to determine the shelf life of tilapia seaweed boba.
Aisyah S. +6 more
doaj +1 more source
Technology Management with Focus on Fish Transposition System (FTS) [PDF]
, 2018 Fish transposition mechanisms have been installed near hydroelectric busses in order to reconnect sections of sectioned rivers and attract fish, offering them a route for the continuity of their displacement, essential for their feeding and reproduction.
AntonioFaianoLuquez, F. (Filipe) +5 more
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Metabolomics-based strategies for fish meat quality, authentication and food safety: a review
Food, Nutrition and HealthFish meat is well known for having exceptional nutritional profile, full of omega-3 fatty acids and essential amino acids which contribute to human health and disease prevention.
Pallavi Bhalavey +13 more
doaj +1 more source
, 2017 We report on small student (high school) project of the Czech Academy of Sciences dealing with animal (fish) eyes and possible application in science and technology. Albeit most fishes have refractive eyes, the recent discoveries confirm that some fishes
Hudec R., Michalova S.
core +1 more source