Results 191 to 200 of about 316,105 (288)

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Phosphodiesterase 4 (PDE 4) Inhibition Reduces Ischemia-Reperfusion-Induced Leucocyte Infiltration, Apoptosis and Mitochondrial Fission Markers in Mice Skeletal Muscles Four Hours After Ischemia Onset. [PDF]

Muscles
Charles AL, Tetsi L, Quiring G, Barnig C, Giannini M, Meyer A, Lejay A, Lugnier C, Geny B.   +8 more
europepmc   +1 more source

Identifying Causes of Reproductive Failure in Zoo‐Housed Bush Dogs (Speothos venaticus) to Improve Ex Situ Management

Zoo Biology, EarlyView.
We distributed a survey to global institutions housing bush dogs (Speothos venaticus) to collect data on factors which may affect litter survival. Information from the Zoological Information Management System (ZIMS) and studbook records supplemented this dataset. We found that within northern temperate regions, the number of pups reared to the age of 1
Alice S. Clark, Veronica B. Cowl, Jane L. Hurst, Lisa Holmes, Paula Stockley   +4 more
wiley   +1 more source

Targeting MFF succinylation: a novel therapeutic strategy for premature ovarian insufficiency by restoring mitochondrial dynamics in granulosa cells. [PDF]

J Ovarian Res
Cao Y, Tong X, Hu W, Wang Y, Lu W, Chen Y, You J, Feng Y, Song Q.   +8 more
europepmc   +1 more source

A Quantised Push‐Sum Distributed Adaptive Momentum Algorithm for Optimisation Over Directed Networks

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT In this paper, we investigate a distributed constrained optimisation problem over directed networks. The agents in the networks conduct local computations and communications, endeavouring to collaboratively minimise the aggregation of all locally known convex cost functions subject to a global constraint set.
Qingguo Lü, Mingyu Guan, Chenglong He, Chen Chen, Xiangguang Dai, Man‐Fai Leung, Wei Zhang   +6 more
wiley   +1 more source

Controlling triplet-pair formation in acene-bridged trimers through locally excited-charge-transfer state mixing. [PDF]

Chem Sci
Sebastian E, Congrave DG, Royakkers J, Royakkers J, Montanaro S, Huang H, Sharma A, Osmólska J, Zhu H, Phansa C, Winkel J, Millington O, Tayebjee MJY, Campos LM, Bronstein H, Rao A.   +15 more
europepmc   +1 more source

Social network dynamics under experimental manipulations of predation risk and food abundance in wild rock hyraxes

Journal of Animal Ecology, EarlyView.
This study combines replicated experimental manipulation, social network analysis, network permutations and meta‐analysis to disentangle active from spatially‐induced changes in animal network structure in the wild. It reveals that short‐term environmental changes primarily alter space use, with limited effects on social structure.
Camille N. M. Bordes, Marine Ammeter, Chuchu Lu, Rosanne Beukeboom, Yael Goll, Julien Bourdiol, Amiyaal Ilany   +6 more
wiley   +1 more source

Histone lactylation leads to perioperative neurocognitive disorders by promoting the expression of Ralbp1 and inducing excessive mitochondrial fission in hippocampal neurons. [PDF]

Cell Mol Life Sci
Meng F, Cao S, Wu W, Zhang M, Jing Q, Xie Z, Sun X, Song J, Fei M, Chen Q, Gao X, Li C.   +11 more
europepmc   +1 more source

Riding out the storm: Behavioural responses of a large herbivore to high‐Arctic winds

Journal of Animal Ecology, EarlyView.
Using 11 years of GPS data from 61 muskoxen in Northeast Greenland, we show how increasing wind speed and Arctic storms reshape movement modes and habitat selection. Muskoxen respond by bedding in dense vegetation, prioritizing energy conservation over foraging, revealing a simple behavioural strategy with potential fitness consequences under ...
Floris M. van Beest, Lars H. Hansen, Niels M. Schmidt   +2 more
wiley   +1 more source

Resveratrol alleviates neuropathic pain associated with restoration of mitochondrial fission-fusion balance in CCI mice. [PDF]

Sci Rep
Xie L, Xu Y, Yang Q, Chang W, Song L, Sun Y.   +5 more
europepmc   +1 more source