Mitochondrial dynamics in cisplatin resistance: molecular mechanisms and therapeutic targeting. [PDF]
Front OncolHuang W, Sun W, Yang Z, Li Y, Wang Z.
europepmc +1 more source
Cancer Science, EarlyView.OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan +8 more
wiley +1 more source
A Non-Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation. [PDF]
Adv Sci (Weinh)Zhang X +13 more
europepmc +1 more source
Exploring the Impact of RNU4‐2 Defects on Neurodevelopmental Disorders in a Korean Population
Clinical Genetics, EarlyView.Among 15 450 Korean individuals, noncoding RNU4‐2 variants, primarily the recurrent de novo n.64_65insT, make up 0.72% of neurodevelopmental disorders. Modeling and RNA‐seq suggest U4/U6 disruption and abnormal 5′ splice‐site selection, supporting routine use of WGS analysis for reanalyzing unresolved cases. ABSTRACT Neurodevelopmental disorders (NDDs)
Juhyeon Hong +20 more
wiley +1 more source
Investigating the Antidepressant Mechanism of Acupuncture with a Focus on Mitochondrial Homeostasis. [PDF]
Int J Gen MedWei Y, Ma Z, Xu N, He Y, Cao M, Wang L.
europepmc +1 more source
Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling
Cell Proliferation, EarlyView.We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo +4 more
wiley +1 more source
Addendum: Widespread potential for phototrophy and convergent reduction of lifecycle complexity in the dimorphic order Caulobacterales. [PDF]
Nat CommunHallgren J +5 more
europepmc +1 more source
Conservation Science and Practice, EarlyView.Mountain gorillas (Gorilla beringei beringei) are found only in transboundary habitat shared by the Democratic Republic of Congo, Rwanda, and Uganda, and are considered as a common pool resource (CPR). From 1990 to 2022, the social‐ecological system was affected by an increase in the number and value of mountain gorilla groups and the number of actors.
Urmila Basu Mallick +6 more
wiley +1 more source
Mitochondrial fission during mitophagy requires both inner and outer mitofissins. [PDF]
EMBO RepFurukawa K +7 more
europepmc +1 more source
Isbaaro: Checkpoints and World Making beyond the State in Somalia
Development and Change, EarlyView.ABSTRACT This article examines the dynamics of checkpoint authority in Somalia, focusing on how kinship, mobility and checkpoint practices intersect to shape political and social orders. Challenging the notion that checkpoint governance is either an expression of state‐like power or indicative of the state's absence, the authors argue that Somali ...
Peer Schouten +2 more
wiley +1 more source