Results 41 to 50 of about 92,954 (262)

The Multifaceted Regulation of Mitochondrial Dynamics During Mitosis

Frontiers in Cell and Developmental Biology, 2021
Mitosis ensures genome integrity by mediating precise segregation of the duplicated genetic material. Segregation of subcellular organelles during mitosis also needs to be tightly coordinated in order to warrant their proper inheritance and cellular ...
Evanthia Pangou, Evanthia Pangou, Evanthia Pangou, Evanthia Pangou, Izabela Sumara, Izabela Sumara, Izabela Sumara, Izabela Sumara   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Current Studies of Mitochondrial Quality Control in the Preeclampsia

Frontiers in Cardiovascular Medicine, 2022
Mitochondria are cellular energy powerhouses that play important roles in regulating cellular processes. Mitochondrial quality control (mQC), including mitochondrial biogenesis, mitophagy, mitochondrial fusion and fission, maintains physiological demand ...
Xiaoqing Peng, Xiaoqing Peng, Xiaoqing Peng, Xiaoqing Peng, Ruirui Hou, Ruirui Hou, Yuanyuan Yang, Zhigang Luo, Yunxia Cao, Yunxia Cao   +9 more
doaj   +1 more source

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez, Alejandro F. Manchón‐Gordón, Antonio Vidal‐Crespo, Rafael Caballero‐Flores, Jhon J. Ipus, Clara F. Conde   +5 more
wiley   +1 more source

Tailored Diketopyrrolopyrrole Derivatives for Efficient Deep‐Red Organic Lasers

Advanced Functional Materials, EarlyView.
Tailored diketopyrrolopyrrole derivatives exhibit high stable amplified spontaneous emission with single or dual bands. Incorporated into distributed‐feedback lasers based on one‐ and two‐dimensional dichromated‐gelatin diffractive gratings, these materials provide a robust, flexible platform for integrated organic deep‐red light sources. ABSTRACT Deep‐
Pablo Pasqués‐Gramage, Abelardo Sánchez‐Oliva, Álex Farrando‐Pérez, Pedro G. Boj, M. Victoria Gómez, Ana M. Rodríguez, Pilar Prieto, Rafael Muñoz‐Mármol, Andrew J. Musser, Iván Torres‐Moya, María A. Díaz‐García   +10 more
wiley   +1 more source

Nuclear astrophysicists at war

Natural Sciences
The question of energy production in stars stimulated an entire generation of young physicists in the 1930s who came to work in this field exploring the fundamentals of quantum and nuclear physics. Their experience and methodologies were essential to the
Michael Wiescher, Karlheinz Langanke
doaj   +1 more source

The physical basis of the fission wave reactor [PDF]

Nuclear Technology and Radiation Protection, 2008
The main idea of slow nuclear fission wave reactor is discussed and short review of the existing works is also presented. The aim of this paper is to clarify the physics of processes, which define the stationary wave of nuclear burning, and to develop ...
Pavlovych Volodymyr M., Khotyayintsev Volodymyr M., Khotyayintseva Olena M.   +2 more
doaj   +1 more source

Molecular Machinery and Pathophysiology of Mitochondrial Dynamics

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are double-membraned organelles that exhibit fluidity. They are the main site of cellular aerobic respiration, providing energy for cell proliferation, migration, and survival; hence, they are called “powerhouses.” Mitochondria play an ...
Yi-Han Chiu, Shu-Chuan Amy Lin, Shu-Chuan Amy Lin, Chen-Hsin Kuo, Chia-Jung Li, Chia-Jung Li   +5 more
doaj   +1 more source