Results 41 to 50 of about 154,384 (314)

Rapid regulation of protein activity in fission yeast

, 2014
Background: The fission yeast Schizosaccharomyces pombe is widely-used as a model organism for the study of a broad range of eukaryotic cellular processes such as cell cycle, genome stability and cell morphology. Despite the availability of extensive set
Sharom, Jeffrey R., Boe, Cathrine A., Tyers, Michael D., Boye, Erik, Kearsey, Stephen, MacNeill, Stuart Andrew, Pai, Chen-Chun, Skjolberg, Henriette C., Grallert, Beata, Garcia, Ignacio   +9 more
core   +1 more source

Plio-Quaternary exhumation history of the central Nepalese Himalaya: 1. Apatite and zircon fission track and apatite [U-Th]/He analyses [PDF]

, 2007
New apatite and zircon fission track and (U-Th)/He analyses serve to document the bedrock cooling history of the central Nepalese Himalaya near the Annapurna Range.
Putkonen, J, D. W. Burbank, Blythe, A.E., Carter, Andrew, Putkonen, J., Blythe, AE, K. Schmidt, Carter, A, Schmidt, K, Schmidt, K., A. E. Blythe, J. Putkonen, A. Carter, Burbank, DW, Burbank, D.W.   +14 more
core   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Deceleration of fusion–fission cycles improves mitochondrial quality control during aging

, 2012
Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Michael Meyer-Hermann, Michael Meyer-Hermann (124166), Andreas S. Reichert (124162), Reichert Andreas S., Heinz D. Osiewacz (120841), Figge, Marc Thilo, Reichert, Andreas S, Marc Thilo Figge, Heinz D Osiewacz, Reichert, Andreas, Meyer-Hermann Michael, Meyer-Hermann, Michael (Prof. Dr.), Osiewacz Heinz D., Meyer-Hermann, Michael, Osiewacz, Heinz D., Andreas S Reichert, Figge Marc Thilo, Marc Thilo Figge (155511), Osiewacz, Heinz D   +18 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Comparison of fission and quasi-fission modes

Physics Letters B, 2021
Quantum shell effects are known to affect the formation of fragments in nuclear fission. Shell effects also affect quasi-fission reactions occurring in heavy-ion collisions. Systematic time-dependent Hartree-Fock simulations of 50Ca+176Yb collisions show that the mass equilibration between the fragments in quasi-fission is stopped when they reach ...
C. Simenel, P. McGlynn, A.S. Umar, K. Godbey   +3 more
openaire   +3 more sources

Fission Xenon Dating [PDF]

, 1975
A new dating method has been developed which uses fission product xenon in a manner similar to radiogenic argon in the 40Ar - 39Ar method. Measurable quantities of spontaneous fission xenon accumulate with time in rocks and minerals containing ...
Teitsma, Albert
core  

Metabolic consequences of neuronal mitochondrial fission ablation [PDF]

, 2016
Dynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality.
Restelli, Lisa Michelle
core   +1 more source

Chronic Alcohol Exposure Induces Aberrant Mitochondrial Morphology and Inhibits Respiratory Capacity in the Medial Prefrontal Cortex of Mice

Frontiers in Neuroscience, 2020
Alcohol use disorder (AUD) is characterized as a chronic, relapsing disease with a pattern of excessive drinking despite negative consequences to an individual’s life. Severe chronic alcohol use impairs the function of the medial prefrontal cortex (mPFC),
Pei Shang, Pei Shang, Daniel Lindberg, Phillip Starski, Lee Peyton, Sa-Ik Hong, Sun Choi, Doo-Sup Choi, Doo-Sup Choi, Doo-Sup Choi   +9 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source