Results 81 to 90 of about 316,105 (288)

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Raft-like microdomains play a key role in mitochondrial impairment in lymphoid cells from patients with Huntington's disease

Journal of Lipid Research, 2012
Huntington's disease (HD) is a genetic neurodegenerative disease characterized by an exceedingly high number of contiguous glutamine residues in the translated protein, huntingtin (Htt).
Laura Ciarlo, Valeria Manganelli, Paola Matarrese, Tina Garofalo, Antonella Tinari, Lucrezia Gambardella, Matteo Marconi, Maria Grasso, Roberta Misasi, Maurizio Sorice, Walter Malorni   +10 more
doaj   +1 more source

Empirical description of beta-delayed fission partial half-lives

, 2015
Background: The process of beta-delayed fission (bDF) provides a versatile tool to study low-energy fission in nuclei far away from the beta-stability line, especially for nuclei which do not fission spontaneously.
Andreyev, AN., Antalic, S., Ghys, L., Huyse, M., Van Duppen, P.   +4 more
core   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Light-particle emission from the fissioning nuclei 126Ba, 188Pt and (266,272,278)/110: theoretical predictions and experimental results

, 2000
We present a comparison of our model treating fission dynamics in conjunction with light-particle (n, p, alpha) evaporation with the available experimental data for the nuclei 126Ba, 188Pt and three isotopes of the element Z=110.
A Surowiec, Abe, Abe, Arnould, B Benoit, B Nerlo-Pomorska, Badimon, Bartel, Bartel, Bartel, Benoit, Blocki, Bl̵ocki, Bl̵ocki, Brack, C Badimon, C Schmitt, Davies, de Goes Brennand, Dietrich, Donadille, E de Goes Brennand, Fröbrich, Fröbrich, Grangé, Gregoire, Guet, Hofmann, Hofmann, Hofmann, Ivanyuk, J Bartel, J Richert, K Dietrich, K Pomorski, Kahn, Kelic, Krappe, L Donadille, M Kowal, Moszynski, Myers, Möller, Nörenberg, Pomorski, Pomorski, Pomorski, Przystupa, Ramamurthy, Sierk, Strumberger, Takigawa, Tilquin, Trentalange, Weisskopf, Yamaji   +55 more
core   +2 more sources

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Fission studies with 140 MeV $\bm{\alpha}$-Particles

, 2009
Binary fission induced by 140 MeV $\alpha$-particles has been measured for $^{\rm nat}$Ag, $^{139}$La, $^{165}$Ho and $^{197}$Au targets. The measured quantities are the total kinetic energies, fragment masses, and fission cross sections. The results are
A. Buttkewitz, C. Wagemans, F. Atchison, F. D. Becchetti, F. Goldenbaum, H. H. Duhm, H. Machner, J. G. Cuninhame, J. R. Nix, L. G. Moretto, R. Vandenboosch, V. S. Barashenkov, W. Strauß   +12 more
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Mitochondrial Membrane Dynamics—Functional Positioning of OPA1

Antioxidants, 2018
The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion.
Hakjoo Lee, Yisang Yoon
doaj   +1 more source

Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia

Brain Sciences, 2020
Mitochondrial morphology, distribution and function are maintained by the opposing forces of mitochondrial fission and fusion, the perturbation of which gives rise to several neurodegenerative disorders.
Philippa C. Fowler, Dwayne J. Byrne, Craig Blackstone, Niamh C. O'Sullivan   +3 more
doaj   +1 more source