Results 81 to 90 of about 82,136 (272)

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Evaluation of reactor neutrino flux: issues and uncertainties [PDF]

, 2016
Evaluation of the reactor $\bar{\nu}_e$ flux and spectrum is an essential ingredient of their application in the neutrino oscillation studies. Two anomalies, i.e.
Vogel, Petr
core   +1 more source

Inverse beta decay reaction in $^{232}$Th and $^{233}$U fission antineutrino flux

, 2004
Energy spectra of antineutrinos coming from $^{232}$Th and $^{233}$U neutron-induced fission are calculated, relevant inverse beta decay $\bar{{\nu}_e}+p \to n + e^{+}$ positron spectra and total cross sections are found.
G. Domogatsky, G. V. Domogatsky, G. V. Domogatsky, J. M. Herndon, K. Schreckenbach, L. A. Mikaelyan, R. Raghavan, V. I. Kopeikin, V. Kopeikin, V. V. Sinev   +9 more
core   +3 more sources

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Prompt fission γ-ray data from spontaneous fission and the mechanism of fission-fragment de-excitation

EPJ Web of Conferences, 2017
The investigation of prompt γ-ray emission in nuclear fission has a great relevance for the assessment of prompt heat generation in a reactor core and for the better understanding of the de-excitation mechanism of fission fragments.
Oberstedt Stephan, Dragic Aleksandar, Gatera Angelique, Göök Alf, Hambsch Franz-Josef, Oberstedt Andreas   +5 more
doaj   +1 more source

Reactor as a Source of Antineutrinos: Thermal Fission Energy

, 2004
Deeper insight into the features of a reactor as a source of antineutrinos is required for making further advances in studying the fundamental properties of the neutrino.
A. G. Beda, G. Audi, L. A. Mikaelyan, M. Appolonio, M. F. James, V. I. Kopeikin, V. I. Kopeikin, V. I. Kopeikin, V. V. Sinev, Yu. Kozlov   +9 more
core   +2 more sources

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Experimental Measurements and Computer Simulation of Fission Product Gamma-Ray Spectra [PDF]

, 1997
Airborne gamma ray spectrometry using high volume scintillation detectors, optionally in conjunction with Ge detectors, has potential for making rapid environmental measurements in response to nuclear accidents. An experimental investigation and computer
Allyson, J.D., Cresswell, A., Department of the Environment, Transport and the Regions: Radioactive Substances Division, McConville, P., Sanderson, D.C.W.   +4 more
core