Results 41 to 50 of about 2,185,416 (252)

Plasmid fitness costs are caused by specific genetic conflicts enabling resolution by compensatory mutation.

open access: yesPLoS Biology, 2021
Plasmids play an important role in bacterial genome evolution by transferring genes between lineages. Fitness costs associated with plasmid carriage are expected to be a barrier to gene exchange, but the causes of plasmid fitness costs are poorly ...
James P J Hall   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Influence of surgery and rehabilitation conditioning on psychophysiological fitness [PDF]

open access: yes, 2008
The purpose of this study was to assess changes in psychophysiological fitness following reconstructive knee surgery and early phase (2.5 months) physical rehabilitation. Nine patients (7 male, 2 female; mean age, 29.9 years) electing to undergo anterior
Bailey, A   +9 more
core  

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Assessment of Inheritance and Fitness Costs Associated with Field-Evolved Resistance to Cry3Bb1 Maize by Western Corn Rootworm

open access: yesToxins, 2017
The western corn rootworm, Diabrotica virgifera virgifera LeConte, is among the most serious insect pests of maize in North America. One strategy used to manage this pest is transgenic maize that produces one or more crystalline (Cry) toxins derived from
Aubrey R. Paolino, Aaron J. Gassmann
doaj   +1 more source

Canada Fitness Survey, 1981

open access: yes, 2023
The Canada fitness survey was established to obtain: - fitness norms for persons aged 7 to 69 - baseline information and trends on activity patterns - baseline information and trends on other factors influencing fitness - trends in ...
Canada Fitness and Amateur Sport, Statistics Canada.
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Herbicide cycling has diverse effects on evolution of resistance in Chlamydomonas reinhardtii

open access: yesEvolutionary Applications, 2013
Cycling pesticides has been proposed as a means of retarding the evolution of resistance, but its efficacy has rarely been empirically tested. We evolved populations of Chlamydomonas reinhardtii in the presence of three herbicides: atrazine, glyphosate ...
Mato Lagator   +3 more
doaj   +1 more source

Opposition to Inbreeding Between Close Kin Reflects Inclusive Fitness Costs

open access: yesFrontiers in Psychology, 2018
Due to the intense selection pressure against inbreeding, humans are expected to possess psychological adaptations that regulate mate choice and avoid inbreeding. From a gene’s-eye perspective, there is little difference in the evolutionary costs between
Jan Antfolk   +6 more
doaj   +1 more source

Fitness costs of individual and combined pyrethroid resistance mechanisms, kdr and CYP-mediated detoxification, in Aedes aegypti.

open access: yesPLoS Neglected Tropical Diseases, 2021
BackgroundAedes aegypti is an important vector of many human diseases and a serious threat to human health due to its wide geographic distribution and preference for human hosts. A. aegypti also has evolved widespread resistance to pyrethroids due to the
Letícia B Smith   +4 more
doaj   +1 more source

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