Results 91 to 100 of about 1,241,383 (345)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Alleviation of water stress in soybean symbiosis by salicylic acid and methyl jasmonate-activated Bradyrhizobium

BMC Plant Biology
Background The use of exogenous compounds with growth-regulatory properties can play an effective part in providing plants with the necessary plastic resources for the synthesis of protective compounds.
Tetiana Nyzhnyk, Edyta Kiedrzyńska, Sergii Kots, Maciej Zalewski, Marcin Kiedrzyński   +4 more
doaj   +1 more source

The Application of Zeolites for Fixation of Cr(VI) Ions in Sediments

Physchem
The aim of the study was to investigate the fixation of Cr(VI) ions from contaminated sediments using synthetic zeolite 4A and natural zeolite clinoptilolite. Parameters such as pH, contact time, adsorption mass and temperature were investigated.
Marjana Simonič
doaj   +1 more source

Intramedullary nail fixation versus locking plate fixation for adults with a fracture of the distal tibia: the UK FixDT RCT

Health Technology Assessment, 2018
Background: The best treatment for fractures of the distal tibia remains controversial. Most of these fractures require surgical fixation, but the outcomes are unpredictable and complications are common. Objectives: To assess disability, quality of life,
Matthew L Costa, Juul Achten, Susie Hennings, Nafisa Boota, James Griffin, Stavros Petrou, Mandy Maredza, Melina Dritsaki, Thomas Wood, James Masters, Ian Pallister, Sarah E Lamb, Nick R Parsons   +12 more
doaj   +1 more source

Triple-functional bone adhesive with enhanced internal fixation, bacteriostasis and osteoinductive properties for open fracture repair

, 2023
Yusheng Yang, Shenghui Su, Shencai Liu, Weilu Liu, Qinfeng Yang, Liangjie Tian, Zilin Tan, Lei Fan, Bin Yu, Jian Wang, Yanjun Hu   +10 more
openalex   +1 more source

Chemosynthetic symbionts of marine invertebrate animals are capable of nitrogen fixation

Nature Microbiology, 2016
Chemosynthetic symbioses are partnerships between invertebrate animals and chemosynthetic bacteria. The latter are the primary producers, providing most of the organic carbon needed for the animal host's nutrition.
J. Petersen, Anna Kemper, Harald R. Gruber-Vodicka, U. Cardini, M. van der Geest, M. Kleiner, Silvia Bulgheresi, M. Mussmann, C. Herbold, B. Seah, Chakkiath Paul Antony, Dan Liu, Alexandra Belitz, M. Weber   +13 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Aplikasi Metode Emersi Fiksatif Berbeda terhadap Morfologi Histologi Testis dan Epididimis Kambing Lokal(Capra sp.)

Jurnal Agripet, 2018
ABSTRAK. Penelitian  ini bertujuan  untuk  melihat morfologi histologi testis dan epididymis  kambing lokal(Capra sp.) dengan umur 1-1,5 tahun. Penelitian ini merupakan penelitian eksperimen laboratorik dengan menggunakan 6 testis dan 6 epididimis yang ...
Fitriani Fitriani, Husmimi Husmimi, Muslim Akmal   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source